Research output per year
Research output per year
Research output
Search results
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2025
Association between symptom characteristics and disease severity in patients suspected of coronary artery disease
Pedersen, O. B., Rasmussen, L. D., Nissen, L., Ejlersen, J. A., Mortensen, J., Gormsen, L. C., Eftekhari, A., Westra, J., Christiansen, E. H., Mark, D. B., Bøttcher, M., Douglas, P. S. & Winther, S., 22 Jan 2025, (E-pub / Early view) In: Journal of Cardiovascular Computed Tomography.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Association between symptom characteristics and disease severity in patients suspected of coronary artery disease
Pedersen, O. B., Rasmussen, L. D., Nissen, L., Ejlersen, J. A., Mortensen, J., Gormsen, L. C., Eftekhari, A., Westra, J., Christiansen, E. H., Mark, D. B., Bøttcher, M., Douglas, P. S. & Winther, S., 2025, (Accepted/In press) In: Journal of Cardiovascular Computed Tomography.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Elevated lipoprotein(a) levels are independently associated with the presence of significant coronary stenosis in de-novo patients with stable chest pain
Brix, G. S., Rasmussen, L. D., Rohde, P. D., Nissen, L., Nyegaard, M., O'Donoghue, M. L., Bøttcher, M. & Winther, S., Apr 2025, In: American Heart Journal. 282, p. 103-113 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2024
Biomarkers for identification of high-risk coronary artery plaques in patients with suspected coronary artery disease
Pedersen, G., Dahl, J. N., Rasmussen, L. D., Garm Blavnsfeldt, A.-B., Böttcher, S. H., Böttcher, M. H., Nyegaard, M., Nissen, L. & Winther, S., 2024, In: Journal of Cardiovascular Computed Tomography. 18, 5, p. 467-475 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Bone mineral density derived from cardiac CT scans: Using contrast enhanced scans for opportunistic screening
Cheneymann, A., Therkildsen, J., Winther, S., Nissen, L., Thygesen, J., Langdahl, B. L., Hauge, E.-M. & Bøttcher, M., Jan 2024, In: Journal of Clinical Densitometry. 27, 1, 101441.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Clinical Likelihood Prediction of Hemodynamically Obstructive Coronary Artery Disease in Patients With Stable Chest Pain
Rasmussen, L. D., Karim, S. R., Westra, J., Nissen, L., Dahl, J. N., Brix, G. S., Knuuti, J., Schmidt, S. E., Holm, N. R., Christiansen, E. H., Eftekhari, A., Bøttcher, M. & Winther, S., Oct 2024, In: JACC: Cardiovascular Imaging. 17, 10, p. 1199-1210 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Contact with general practice in patients with suspected chronic coronary syndrome before and after CT angiography compared with the general population
Nissen, L., Søby, J. H., de Thurah, A., Prescott, E., Prior, A., Winther, S. & Bøttcher, M., 1 Nov 2024, In: European heart journal - Quality of care & clinical outcomes. 10, 7, p. 623-631 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Diagnostic performance of clinical likelihood models of obstructive coronary artery disease to predict myocardial perfusion defects
Rasmussen, L. D., Albertsen, L. E. B., Nissen, L., Ejlersen, J. A., Isaksen, C., Murphy, T., Søndergaard, H. M., Kirk, J., Brix, L., Gormsen, L. C., Petersen, S. E., Bøttcher, M. & Winther, S., 1 Jan 2024, In: European Heart Journal Cardiovascular Imaging. 25, 1, p. 39-47 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Predicting the presence of coronary plaques featuring high-risk characteristics using polygenic risk scores and targeted proteomics in patients with suspected coronary artery disease
Møller, P. L., Rohde, P. D., Dahl, J. N., Rasmussen, L. D., Nissen, L., Schmidt, S. E., McGilligan, V., Gudbjartsson, D. F., Stefansson, K., Holm, H., Bentzon, J. F., Bøttcher, M., Winther, S. & Nyegaard, M., Dec 2024, In: Genome Medicine. 16, 1, 40.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
2023
A genome-wide genomic score added to standard recommended stratification tools does not improve the identification of patients with very low bone mineral density
Therkildsen, J., Rohde, P. D., Nissen, L., Thygesen, J., Hauge, E.-M., Langdahl, B. L., Boettcher, M., Nyegaard, M. & Winther, S., Nov 2023, In: Osteoporosis International. 34, 11, p. 1893-1906 14 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile -
Association between socioeconomic position and coronary artery calcium score in patients with symptoms suggestive of obstructive coronary artery disease
Nissen, L., Winding, T. N., Schmidt, S. E., Hasan Shafi, B., Bossano Prescott, E. I., Nyegaard, M., Winther, S. & Bøttcher, M., Mar 2023, In: Journal of Cardiovascular Computed Tomography. 17, 2, p. 138-143 6 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Combining Polygenic and Proteomic Risk Scores With Clinical Risk Factors to Improve Performance for Diagnosing Absence of Coronary Artery Disease in Patients With De Novo Chest Pain
Møller, P. L., Rohde, P. D., Dahl, J. N., Rasmussen, L. D., Schmidt, S. E., Nissen, L., McGilligan, V., Bentzon, J. F., Gudbjartsson, D. F., Stefansson, K., Holm, H., Winther, S., Bøttcher, M. & Nyegaard, M., 1 Oct 2023, In: Circulation: Genomic and Precision Medicine. 16, 5, p. 442-451 10 p., e004053.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Radiomics analysis enhances the diagnostic performance of CMR stress perfusion: a proof-of-concept study using the Dan-NICAD dataset
Raisi-Estabragh, Z., Martin-Isla, C., Nissen, L., Szabo, L., Campello, V. M., Escalera, S., Winther, S., Bøttcher, M., Lekadir, K. & Petersen, S. E., Sept 2023, In: Frontiers in Cardiovascular Medicine. 10, 1141026.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
2022
Improved pre-test likelihood estimation of coronary artery disease using phonocardiography
Larsen, B. S., Winther, S., Nissen, L., Diederichsen, A., Bøttcher, M., Renker, M., Struijk, J. J., Christensen, M. G. & Schmidt, S. E., 1 Dec 2022, In: European Heart Journal - Digital Health. 3, 4, p. 600-609 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
The PROMISE Minimal Risk Score Improves Risk Classification of Symptomatic Patients With Suspected CAD
Rasmussen, L. D., Fordyce, C. B., Nissen, L., Hill, C. L., Alhanti, B., Hoffmann, U., Udelson, J., Bøttcher, M., Douglas, P. S. & Winther, S., Aug 2022, In: JACC: Cardiovascular Imaging. 15, 8, p. 1442-1454 13 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
2021
Advanced heart sound analysis as a new prognostic marker in stable coronary artery disease
Winther, S., Nissen, L., Schmidt, S. E., Westra, J., Andersen, I. T., Nyegaard, M., Madsen, L. H., Knudsen, L. L., Urbonaviciene, G., Larsen, B. S., Struijk, J. J., Frost, L., Holm, N. R., Christiansen, E. H., Botker, H. E. & Bottcher, M., Jun 2021, In: European Heart Journal - Digital Health. 3, 1, p. 279-289 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Implementation of coronary computed tomography angiography as nationally recommended first-line test in patients with suspected chronic coronary syndrome: impact on the use of invasive coronary angiography and revascularization
Nissen, L., Winther, S., Schmidt, M., Rønnow Sand, N. P., Urbonaviciene, G., Zelechowski, M. W., Christensen, M. K., Busk, M., Lambrechtsen, J., Diederichsen, A., Elpert, F.-P., Grove, E. L., Bøtker, H. E. & Bøttcher, M., 1 Dec 2021, In: European Heart Journal Cardiovascular Imaging. 21, 12, p. 1353-1362 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
One-step anatomic and function testing by cardiac CT versus second-line functional testing in symptomatic patients with coronary artery stenosis: head-to-head comparison of CT-derived fractional flow reserve and myocardial perfusion imaging
Westra, J., Li, Z., Rasmussen, L. D., Winther, S., Li, G., Nissen, L., Petersen, S. E., Ejlersen, J. A., Isaksen, C., Gormsen, L. C., Urbonaviciene, G., Eftekhari, A., Weng, T., Qu, X., Bøtker, H. E., Christiansen, E. H., Holm, N. R., Bøttcher, M. & Tu, S., Sept 2021, In: EuroIntervention. 17, 7, p. 576-583 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Polygenic Risk Score-enhanced Risk Stratification of Coronary Artery Disease in Patients with Stable Chest Pain
Christiansen, M. K., Winther, S., Nissen, L., Vilhjálmsson, B. J., Frost, L., Johansen, J. K., Loof Møller, P., Schmidt, S. E., Westra, J. S., Holm, N. R., Jensen, H. K., Christiansen, E. H., Guðbjartsson, D. F., Hólm, H., Stefansson, K., Bøtker, H. E., Bøttcher, M. & Nyegaard, M., 1 Jun 2021, In: Circulation: Genomic and Precision Medicine. 14, 3, p. 323-330 8 p., 003298.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Sex Differences in the Association Between Bone Mineral Density and Coronary Artery Disease in Patients Referred for Cardiac Computed Tomography
Therkildsen, J., Winther, S., Nissen, L., Jørgensen, H. S., Thygesen, J., Ivarsen, P., Frost, L., Isaksen, C., Langdahl, B. L., Hauge, E.-M. & Böttcher, M., Jan 2021, In: Journal of Clinical Densitometry. 24, 1, p. 55-66 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Sortilin as a Biomarker for Cardiovascular Disease Revisited
Møller, P. L., Rohde, P. D., Winther, S., Breining, P., Nissen, L., Nykjær, A., Böttcher, M., Nyegaard, M. & Kjolby, M., Apr 2021, In: Frontiers in Cardiovascular Medicine. 8, 652584.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Spectral analysis of heart sounds associated with coronary artery disease
Larsen, B. S., Winther, S., Nissen, L., Diederichsen, A., Bøttcher, M., Jan Struijk, J., Christensen, M. G. & Schmidt, S. E., Oct 2021, In: Physiological Measurement. 42, 10, 11 p., 105013.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile -
Validation and update of the minimal risk tool in patients suspected of chronic coronary syndrome
Rasmussen, L. D., Nissen, L., Westra, J., Knudsen, L. L., Madsen, L. H., Holm, N. R., Christiansen, E. H., Bøtker, H. E., Bøttcher, M. & Winther, S., Feb 2021, In: The International Journal of Cardiovascular Imaging. 37, 2, p. 699–706 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2020
Comparison of quantitative flow ratio and fractional flow reserve with myocardial perfusion scintigraphy and cardiovascular magnetic resonance as reference standard. A Dan-NICAD substudy
Sejr-Hansen, M., Westra, J., Winther, S., Tu, S., Nissen, L., Gormsen, L., Petersen, S. E., Ejlersen, J., Isaksen, C., Bøtker, H. E., Bøttcher, M., Christiansen, E. H. & Holm, N. R., 1 Mar 2020, In: The International Journal of Cardiovascular Imaging. 36, 3, p. 395-402 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile -
Feasibility of Opportunistic Screening for Low Thoracic Bone Mineral Density in Patients Referred for Routine Cardiac CT
Therkildsen, J., Winther, S., Nissen, L., Jørgensen, H. S., Thygesen, J., Ivarsen, P., Frost, L., Langdahl, B. L., Hauge, E.-M. & Böttcher, M., 1 Jan 2020, In: Journal of Clinical Densitometry. 23, 1, p. 117-127 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Genetic Risk of Coronary Artery Disease, Features of Atherosclerosis, and Coronary Plaque Burden
Christiansen, M. K., Nissen, L., Winther, S., Møller, P. L., Frost, L., Johansen, J. K., Jensen, H. K., Guðbjartsson, D., Holm, H., Stefánsson, K., Bøtker, H. E., Bøttcher, M. & Nyegaard, M., 2020, In: Journal of the American Heart Association. 9, 3, 17 p., e014795.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Incorporating Coronary Calcification Into Pre-Test Assessment of the Likelihood of Coronary Artery Disease
Winther, S., Schmidt, S. E., Mayrhofer, T., Bøtker, H. E., Hoffmann, U., Douglas, P. S., Wijns, W., Bax, J., Nissen, L., Lynggaard, V., Christiansen, J. J., Saraste, A., Bøttcher, M. & Knuuti, J., Nov 2020, In: Journal of the American College of Cardiology. 76, 21, p. 2421-2432 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Prediction of Coronary Revascularization in Stable Angina: Comparison of FFRCT With CMR Stress Perfusion Imaging
Rønnow Sand, N. P., Nissen, L., Winther, S., Petersen, S. E., Westra, J., Christiansen, E. H., Larsen, P., Holm, N. R., Isaksen, C., Urbonaviciene, G., Deibjerg, L., Husain, M., Thomsen, K. K., Rohold, A., Bøtker, H. E. & Bøttcher, M., Apr 2020, In: JACC: Cardiovascular Imaging. 13, 4, p. 994-1004 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile -
Thoracic Bone Mineral Density Derived from Cardiac CT Is Associated with Greater Fracture Rate
Therkildsen, J., Nissen, L., Jørgensen, H. S., Thygesen, J., Ivarsen, P., Frost, L., Isaksen, C., Langdahl, B. L., Hauge, E. M., Boettcher, M. & Winther, S., Sept 2020, In: Radiology. 296, 3, p. 499-508 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile -
2019
Coronary artery disease risk reclassification by a new acoustic-based score
Schmidt, S. E., Winther, S., Larsen, B. S., Groenhoej, M. H., Nissen, L., Westra, J., Frost, L., Holm, N. R., Mickley, H., Steffensen, F. H., Lambrechtsen, J., Nørskov, M. S., Struijk, J. J., Diederichsen, A. C. P. & Boettcher, M., Nov 2019, In: The International Journal of Cardiovascular Imaging. 35, 11, p. 2019-2028 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile -
Influence of Cardiac CT based disease severity and clinical symptoms on the diagnostic performance of myocardial perfusion
Nissen, L., Winther, S., Westra, J., Ejlersen, J. A., Isaksen, C., Rossi, A., Holm, N. R., Urbonaviciene, G., Gormsen, L. C., Madsen, L. H., Christiansen, E. H., Maeng, M., Knudsen, L. L., Frost, L., Brix, L., Bøtker, H. E., Petersen, S. E. & Bøttcher, M., Sept 2019, In: The International Journal of Cardiovascular Imaging. 35, 9, p. 1709-1720 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Pre-test probability prediction in patients with a low to intermediate probability of coronary artery disease: a prospective study with a fractional flow reserve endpoint
Winther, S., Nissen, L., Westra, J., Schmidt, S. E., Bouteldja, N., Knudsen, L. L., Madsen, L. H., Frost, L., Urbonaviciene, G., Holm, N. R., Christiansen, E. H., Bøtker, H. E. & Bøttcher, M., Nov 2019, In: European Heart Journal Cardiovascular Imaging. 20, 11, p. 1208-1218 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2018
Diagnosing coronary artery disease after a positive coronary computed tomography angiography: the Dan-NICAD open label, parallel, head to head, randomized controlled diagnostic accuracy trial of cardiovascular magnetic resonance and myocardial perfusion scintigraphy
Nissen, L., Winther, S., Westra, J., Ejlersen, J. A., Isaksen, C., Rossi, A., Holm, N. R., Urbonaviciene, G., Gormsen, L. C., Madsen, L. H., Christiansen, E. H., Maeng, M., Knudsen, L. L., Frost, L., Brix, L., Bøtker, H. E., Petersen, S. E. & Bøttcher, M., 1 Apr 2018, In: European Heart Journal Cardiovascular Imaging. 19, 4, p. 369-377 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Diagnostic performance of an acoustic-based system for coronary artery disease risk stratification
Winther, S., Nissen, L., Schmidt, S. E., Westra, J. S., Rasmussen, L. D., Knudsen, L. L., Madsen, L. H., Kirk Johansen, J., Larsen, B. S., Struijk, J. J., Frost, L., Holm, N. R., Christiansen, E. H., Botker, H. E. & Bøttcher, M., Jun 2018, In: Heart. 104, 11, p. 928-935 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile -
Evaluation of Coronary Artery Stenosis by Quantitative Flow Ratio During Invasive Coronary Angiography: The WIFI II Study (Wire-Free Functional Imaging II)
Westra, J., Tu, S., Winther, S., Nissen, L., Vestergaard, M.-B., Andersen, B. K., Holck, E. N., Fox Maule, C., Johansen, J. K., Andreasen, L. N., Simonsen, J. K., Zhang, Y., Kristensen, S. D., Maeng, M., Kaltoft, A., Terkelsen, C. J., Krusell, L. R., Jakobsen, L., Reiber, J. H. C. & Lassen, J. F. & 4 others, , Mar 2018, In: Circulation: Cardiovascular Imaging. 11, 3, e007107.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile -
2016
Danish study of Non-Invasive testintg in Coronary artery disease (Dan-NICAD): Study protocol for a randomised controlled trial
Nissen, L., Winther, S., Isaksen, C., Ejlersen, J. A., Brix, L., Urbonaviciene, G., Frost, L., Helleskov Madsen, L., Lyhne Knudsen, L., Schmidt, S. E., Holm, N. R., Maeng, M., Nyegaard, M., Bøtker, H. E. & Bøttcher, M., 26 May 2016, In: Trials. 17, 1, 11 p., 262.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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The predictive validity of RETTS-HEV as an acuity triage tool in the emergency department of a Danish Regional Hospital
Pérez, N., Nissen, L., Nielsen, R. F., Petersen, P. & Biering, K., 2016, In: European Journal of Emergency Medicine. 23, 1, p. 33–37 5 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review