Aarhus University Seal / Aarhus Universitets segl

Lotte Bjergbæk

  1. 2019
  2. Published

    Abortive activity of Topoisomerase I : a challenge for genome integrity? / Jakobsen, Kristoffer Pors; Andersen, Anni H.; Bjergbaek, Lotte.

    In: Current Genetics, Vol. 65, No. 5, 10.2019, p. 1141-1144.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  3. Published

    Minimal Resection Takes Place during Break-Induced Replication Repair of Collapsed Replication Forks and Is Controlled by Strand Invasion. / Jakobsen, Kristoffer P.; Nielsen, Kirstine O.; Løvschal, Katrine V.; Rødgaard, Morten; Andersen, Anni H.; Bjergbæk, Lotte.

    In: Cell Reports, Vol. 26, No. 4, e3, 01.2019, p. 836-844.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. 2018
  5. Published

    Using the Flp Recombinase to Induce Site-Specific Protein-DNA Nicks. / Jakobsen, Kristoffer P; Bjergbæk, Lotte.

    Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair. ed. / Marie Spies; Anna Malkova. Vol. 601 Elsevier, 2018. p. 1-25 (Methods in Enzymology).

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  6. 2015
  7. Published

    Top2 and Sgs1-Top3 Act Redundantly to Ensure rDNA Replication Termination. / Mundbjerg, Kamilla; Jørgensen, Signe W; Fredsøe, Jacob; Nielsen, Ida; Pedersen, Jakob Madsen; Bentsen, Iben Bach; Lisby, Michael; Bjergbaek, Lotte; Andersen, Anni H.

    In: P L o S Genetics, Vol. 11, No. 12, 02.12.2015, p. e1005697.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. Published

    DNA REPAIR. Mus81 and converging forks limit the mutagenicity of replication fork breakage. / Mayle, Ryan; Campbell, Ian M; Beck, Christine R; Yu, Yang; Wilson, Marenda; Shaw, Chad A; Bjergbaek, Lotte; Lupski, James R; Ira, Grzegorz.

    In: Science, Vol. 349, No. 6249, 14.08.2015, p. 742-747.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    DNA Topoisomerases Are Required for Preinitiation Complex Assembly during GAL Gene Activation. / Roedgaard, Morten; Fredsoe, Jacob; Pedersen, Jakob Madsen; Bjergbaek, Lotte; Andersen, Anni Hangaard.

    In: PLOS ONE, Vol. 10, No. 7, e0132739, 14.07.2015, p. 1-15.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Published

    Real-time investigation of human topoisomerase I reaction kinetics using an optical sensor : a fast method for drug screening and determination of active enzyme concentrations. / Kristoffersen, Emil L; Jørgensen, Line A; Franch, Oskar; Etzerodt, Michael; Frøhlich, Rikke; Bjergbæk, Lotte; Stougaard, Magnus; Ho, Yi-Ping; Knudsen, Birgitta R.

    In: Nanoscale, Vol. 7, No. 21, 21.05.2015, p. 9825-9834.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. 2013
  12. Published

    A Rad53 Independent Function of Rad9 Becomes Crucial for Genome Maintenance in the Absence of the RecQ Helicase Sgs1. / Nielsen, Ida; Bentsen, Iben Bach; Andersen, Anni Hangaard; Gasser, Susan M.; Bjergbæk, Lotte.

    In: P L o S One, Vol. 8, No. 11, e81015, 20.11.2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    MRX protects fork integrity at protein–DNA barriers, and its absence causes checkpoint activation dependent on chromatin context. / Bentsen, Iben Bach; Nielsen, Ida; Lisby, Michael; Nielsen, Helena Berner Nedergaard; Sen Gupta, Souvik; Mundbjerg, Kamilla; Andersen, Anni Hangaard; Bjergbæk, Lotte.

    In: Nucleic Acids Research, Vol. 41, No. 5, 01.02.2013, p. 3173-3189.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. 2012
  15. Published

    DNA Topoisomerases Maintain Promoters in a State Competent for Transcriptional Activation in Saccharomyces cerevisiae. / Pedersen, Jakob Madsen; Fredsøe, Jacob Christian; Rødgaard, Morten Terpager; Andreasen, Lotte; Mundbjerg, Kamilla; Kruhøffer, Mogens; Brinch, Marie; Schierup, Mikkel Heide; Bjergbæk, Lotte; Andersen, Anni Hangaard.

    In: P L o S Genetics, Vol. 8, No. 12 e1003128, 20.12.2012, p. 1-15.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published

    DNA repair protocols. / Bjergbæk, Lotte.

    3. ed. / ed. Totowa, N.J : Humana Press, 2012. 648 p.

    Research output: Book/anthology/dissertation/reportBook

  17. Published

    Studying repair of a single protein-bound nick in vivo using the Flp-nick system. / Nielsen, Ida; Andersen, Anni Hangaard; Bjergbæk, Lotte.

    DNA repair protocols. ed. / Lotte Bjergbæk. Vol. 920 Humana Press, 2012. p. 393-415 (Methods in Molecular Biology, Vol. 920).

    Research output: Contribution to book/anthology/report/proceedingBook chapterCommunication

  18. 2011
  19. Published

    Completion of unidirectional replication requires Top2 or Sgs1. / Mundbjerg, Kamilla; Nielsen, Ida; Bentsen, Iben Bach; Lisby, Michael; Bjergbæk, Lotte; Andersen, Anni Hangaard.

    2011.

    Research output: Contribution to conferencePosterResearch

  20. Published

    The MRX complex is required for replisome integrity as revealed from genomic loci with unidirectional replication. / Bentsen, Iben Bach; Nielsen, Ida; Nielsen, Helena Berner Nedergaard; Mundbjerg, Kamilla; Lisby, Michael; Andersen, Anni Hangaard; Bjergbæk, Lotte.

    2011. Poster session presented at Keystone Symposia, DNA replication and recombination, Keystone, Colorado, United States.

    Research output: Contribution to conferencePosterResearch

  21. 2010
  22. Published

    A Flp-nick system to study repair of a single protein-bound nick in vivo. / Nielsen, Ida; Bentsen, Iben Bach; Lisby, Michael; Hansen, Sabine; Jørgensen, Natasja Leth; Mundbjerg, Kamilla; Andersen, Anni Hangaard; Bjergbæk, Lotte.

    2010. Poster session presented at Biological impact of alternatively structured DNA, FASEB summer research conference, Steamboat Springs, Colorado, United States.

    Research output: Contribution to conferencePosterResearch

  23. 2009
  24. Published

    A Flp-nick system to study repair of a single protein-bound nick in vivo. / Nielsen, Ida; Bentsen, Iben Bach; Lisby, M.; Hansen, S.; Mundbjerg, Kamilla; Andersen, Anni Hangaard; Bjergbæk, Lotte.

    In: Nature Methods, 2009, p. 753-7.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    A Flp-nick system to study repair of a single protein-bound nick in vivo -  a model system for repair of Top1-DNA cleavage intermediates. / Nielsen, Ida; Bentsen, Iben Bach; Hansen, Sabine; Mundbjerg, Kamilla; Andersen, Anni Hangaard; Bjergbæk, Lotte.

    2009. Poster session presented at Chromatin, Replication and Chromosomal Stability Conference, Copenhagen, .

    Research output: Contribution to conferencePosterResearch

  26. Published

    Roles of Topoisomerase I and II in the S Phase of the Cell Cycle. / Mundbjerg, Kamilla; Nielsen, Ida; Bentsen, Iben Bach; Bjergbæk, Lotte; Andersen, Anni Hangaard.

    2009. Poster session presented at MBI Annual Meeting 2009, Aarhus, Denmark.

    Research output: Contribution to conferencePosterResearch

  27. Published

    Roles of topoisomerase I and II in the S phase of the cell cycle. / Mundbjerg, Kamilla; Nielsen, Ida; Bentsen, Iben Bach; Bjergbæk, Lotte; Andersen, Anni Hangaard.

    2009. Poster session presented at Chromatin, Replication and Chromosomal Stability Conference, Copenhagen, .

    Research output: Contribution to conferencePosterResearch

  28. Published

    Studies of replication fork management upon the encounter with a protein-DNA barrier at a single genomic site. / Bentsen, Iben Bach; Nielsen, Ida; Mundbjerg, Kamilla; Andersen, Anni Hangaard; Bjergbæk, Lotte.

    2009. Abstract from MBI Annual Meeting 2009, Aarhus, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  29. Published

    Studies of replication fork management upon the  encounter with a protein-DNA barrier at a single genomic site. / Bentsen, Iben Bach; Nielsen, Ida; Mundbjerg, Kamilla; Andersen, Anni Hangaard; Bjergbæk, Lotte.

    2009. Poster session presented at Chromatin, Replication and Chromosomal Stability Conference, Copenhagen, .

    Research output: Contribution to conferencePosterResearch

  30. Published

    Top2 or Sgs1 are necessary to avoid checkpoint activation in late S phase. / Mundbjerg, Kamilla; Nielsen, Ida; Bentsen, Iben Bach; Bjergbæk, Lotte; Andersen, Anni Hangaard.

    2009. Poster session presented at Eukaryotic DNA replication and genome maintenance, Cold Spring Harbor, United States.

    Research output: Contribution to conferencePosterResearch

  31. 2008
  32. Published

    DNA topoisomerases - Cellular tools with huge impact on genome stability. / Mundbjerg, Kamilla; Pedersen, Jakob Madsen; Bendsen, Simon; Andreasen, Lotte; Knudsen, Birgitta R.; Bjergbaek, Lotte; Andersen, Anni Hangaard.

    2008. Abstract from Eighth international conference of anticancer research, Kos, Greece.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  33. Published

    Identification of protein factors required during stalled replication at a protein-DNA barrier. / Bentsen, Iben Bach; Nielsen, Ida; Kristensen, Kamilla; Andersen, Anni Hangaard; Bjergbæk, Lotte.

    2008. Poster session presented at DNA replication and recombination, Santa Fe, United States.

    Research output: Contribution to conferencePosterResearch

  34. Published

    Rad9 is required for genomic maintenace in cells lacking the RecQ helicase Sgs1. / Nielsen, Ida; Bentsen, Iben Bach; Lisby, Michael; Gasser, Susan M; Bjergbæk, Lotte.

    2008. Poster session presented at DNA replication and recombination, Santa Fe, United States.

    Research output: Contribution to conferencePosterResearch

  35. 2007
  36. Published

    Determination of S Phase Specific Roles of Topoisomerase I and II Based on Interactions with Sgs1. / Mundbjerg, Kamilla; Bjergbæk, Lotte; Andersen, Anni Hangaard.

    2007. Poster session presented at MBI Annual Meeting 2007, Aarhus, Denmark.

    Research output: Contribution to conferencePosterResearch

  37. 2006
  38. Published

    RecQ helicases:lessons from model organisms. / Cobb, Jennifer; Bjergbæk, Lotte.

    In: Nucleic Acids Research, Vol. 34, No. 15, 2006, p. 4106-4114.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearch

  39. Published

    Stimulated activity of human topoisomerase IIα and IIβ on RNA containing substrates. / Wang, Y.; Knudsen, Birgitta R.; Bjergbæk, Lotte; Westergaard, Ole; Andersen, Anni Hangaard.

    In: Journal of Biological Chemistry, Vol. 274, 2006, p. 22839-22846.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. 2005
  41. Published

    Genome instability as a cause of ageing and cancer: Implications of RecQ helicases. / Skouboe, Camilla; Bjergbæk, Lotte; Andersen, Anni Hangaard.

    In: Signal Transduction, Vol. 3, 2005, p. 142-151.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearch

  42. Published

    Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance. / Bjergbæk, Lotte; Cobb, Jennifer A.; Tsai-Pflugfelder, Monica; Gasser, Susan M.

    In: E M B O Journal, Vol. 24, 2005, p. 405-417.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  43. Published

    Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations. / Cobb, J.A.; Schleker, T.; Rojas, V.; Bjergbæk, Lotte; Tercero, J.A.; Gasser, S.M.

    In: Genes and Div., Vol. 19, 2005, p. 3055-3069.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  44. 2004
  45. Published

    Hindering the strand passage reaction of human topoisomerase II alpha without disturbing DNA cleavage, ATP hydrolysis or operation of the N-terminal clamp. / Østergaard, V.H.; Giangiacomo, L.; Bjergbæk, L.; Knudsen, B.R.; Andersen, A.H.

    In: Journal of Biological Chemistry, Vol. 279, 2004, p. 28093-28099.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  46. Published

    The tranducer domain is important for clamp operation in human DNA topoisomerase II alpha. / Østergaard, V.H.; Bjergbæk, L.; Skouboe, C.; Giangiacomo, L.; Knudsen, B.R.; Andersen, A.H.

    In: Journal of Biological Chemistry, Vol. 279, 2004, p. 1684-1691.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  47. 2003
  48. Published

    A human topoisomerase IIα heterodimer with only one ATP binding site can go through successive catalytic cycles. / Skouboe, Camilla; Bjergbæk, Lotte; Østergaard, Vibe; Larsen, Morten K.; Knudsen, Birgitta R.; Andersen, Anni Hangaard.

    In: Journal of Biological Chemistry, Vol. 278, 2003, p. 5768-5774.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  49. Published

    RecQ helicases and topoisomerase III in cancer and aging. / Laursen, L.V.; Bjergbæk, L.; Murray, J.M.; Andersen, A.H.

    In: Biogerontology, Vol. 4, 2003, p. 275-287.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  50. Published

    RecQ helicases: Multiple roles in genome maintenance. / Khakhar, Rakesh R.; Cobb, Jennifer A.; Bjergbæk, Lotte; Hickson, Ian D.; Gasser, Susan M.

    In: Trends Cell Biol., Vol. 9, 2003, p. 493-501.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearch

  51. Published

    The stabilization of DNA polymerases at stalled replication forks requires Mec1 and the RecQ helicase Sgs1. / Cobb, Jennifer A.; Bjergbæk, Lotte; Shimada, Kenji; Frei, Chrstian; Gasser, Susan M.

    In: E M B O Journal, Vol. 22, 2003, p. 4325-4336.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  52. 2002
  53. Published

    RecQ helicases and genome stability: lessons from model organisms and human disease. / Bjergbæk, Lotte; Cobb, Jennifer A.

    In: Swiss Medical Weekly, Vol. 132, 2002, p. 433-442.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearch

  54. Published

    RecQ helicases: at the heart of genetic stability. / Cobb, Jennifer A.; Bjergbæk, Lotte; Gasser, Susan M.

    In: F E B S Letters, Vol. 26495, 2002, p. 1-6.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearch

  55. 2000
  56. Published

    Communication between the ATPase and cleavage/religation domains of human topoisomerase IIα. / Bjergbæk, L.; Kingma, P.; Nielsen, I.S.; Wang, Y.; Westergaard, O.; Osheroff, N.; Andersen, A.H.

    In: Journal of Biological Chemistry, Vol. 275, 2000, p. 13041-13048.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  57. 1999
  58. Published

    Stimulated activity of human topoisomerase IIα and IIβ on RNA containing substrates. / Wang, Y.; Knudsen, B.R.; Bjergbæk, L.; Westergaard, O.; Andersen, Anni Hangaard.

    In: Journal of Biological Chemistry, Vol. 274, 1999, p. 22839-22846.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  59. Published

    Using a biochemical approach to identify the primary dimerization regions in human DNA topoisomerase IIα. / Bjergbæk, L.; Jensen, S.; Westergaard, O.; Andersen, A.H.

    In: Journal of Biological Chemistry, Vol. 274, 1999, p. 26529-26536.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review