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Sortilin in microglia reactivity

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Neuropathic pain is a serious neurological disease estimated to affect around 8% of the Western population. It can be caused by either direct injuries to the peripheral nervous system (e.g. surgery) or indirect injuries (e.g. diabetes or cancer). Unfortunately, patients very often do not respond to, experience severe side effects or become resistant to the treatment. Hence, there is an enormous unmet need to develop more targeted therapeutic treatments.
Neuroinflammation is a major contributing factor in the development and maintenance of neuropathic pain. It is well known that activation of microglia is essential in the spinal neuroinflammatory process underlying development of neuropathic pain after a peripheral nerve injury (PNI). Unpublished data from Sortilin deficient mice shows that lack of the neuronal receptor Sortilin decreases development of neuropathic pain after PNI. As Sortilin is reported to influence the inflammatory response in macrophages and T-cells, we speculate that Sortilin has a similar role in microglia. Therefore, the aim of this project is to understand how Sortilin influences the spinal microglial response following PNI.
This project is divided into two parts: 1) The in vitro part focuses on investigating primary microglia cultures from wild type and Sortilin deficient mice by comparing profiles of released cytokines following an injury mimicking stimulation, 2) The in vivo part compares cytokine expressions in spinal cord lysates after PNI.
We hope that this study will improve understanding of the microglial response in the central nervous system after PNI and contribute to development of better and more targeted treatments of neuropathic pain.
Original languageEnglish
Publication year27 Jan 2017
Publication statusPublished - 27 Jan 2017
EventPhD Day 2017: Science - keep it simple - Aarhus Universitet, Aarhus, Denmark
Duration: 27 Jan 201727 Jan 2017
http://phd.au.dk/gradschools/health/phdday/

Conference

ConferencePhD Day 2017
LocationAarhus Universitet
CountryDenmark
CityAarhus
Period27/01/201727/01/2017
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