Lise Lotte Hansen

Strategies for Integrated Analysis of Genetic, Epigenetic, and Gene Expression Variation in Cancer: Addressing the Challenges

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Documents

  • Louise Bruun Thingholm, Denmark
  • Lars Andersen, Dept. of Clinical Genetics, Odense University Hospital., Denmark
  • Enes Makalic, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia., Australia
  • Melissa C. Southey, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia., Australia
  • Mads Thomassen, Dept. of Clinical Genetics, Odense University Hospital., Denmark
  • Lise Lotte Hansen
The development and progression of cancer, a collection of diseases with complex genetic architectures, is facilitated by the interplay of multiple etiological factors. This complexity challenges the traditional single-platform study design and calls for an integrated approach to data analysis. However, integration of heterogeneous measurements of biological variation is a non-trivial exercise due to the diversity of the human genome and the variety of output data formats and genome coverage obtained from the commonly used molecular platforms. This review article will provide an introduction to integration strategies used for analyzing genetic risk factors for cancer. We critically examine the ability of these strategies to handle the complexity of the human genome and also accommodate information about the biological and functional interactions between the elements that have been measured—making the assessment of disease risk against a composite genomic factor possible. The focus of this review is to provide an overview and introduction to the main strategies and to discuss where there is a need for further development.
Original languageEnglish
JournalFrontiers in Genetics
Volume7
Pages (from-to)1-13
Number of pages13
ISSN1664-8021
Publication statusPublished - 1 Feb 2016

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