Lise Lotte Hansen

High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer

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  • Department of Human Genetics
  • Department of Experimental Clinical Oncology
  • Bioinformatics Research Centre (BiRC)
Identification of specific mutation targets in cancer may lead to discovery of the genes modulating cancer susceptibility and/or prognosis. The RGSL1, RGS16, and RGS8 genes within the 1q25.3 region belong to the novel family of regulators of G protein signaling (RGS) genes, which increase the GTPase activity of the Gα subunit to attenuate signaling from the G protein-coupled receptor. We evaluated the use of high-resolution melting (HRM) to screen for mutations in the genes of interest and assess their clinical significance.
Original languageEnglish
JournalCancer Epidemiology, Biomarkers & Prevention
Pages (from-to)397-407
Number of pages11
Publication statusPublished - 1 Mar 2011

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