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Lisa Maria Wu

Programmed environmental illumination during autologous stem cell transplantation hospitalization for the treatment of multiple myeloma reduces severity of depression: A preliminary randomized controlled trial

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  • Heiðdís B Valdimarsdottir, Icahn School of Medicine at Mount Sinai
  • ,
  • Mariana G Figueiro, Lally School of Management and Technology, Rensselaer Polytechnic Institute (Troy, New York)
  • ,
  • William Holden, Icahn School of Medicine at Mount Sinai
  • ,
  • Susan Lutgendorf, University of Iowa
  • ,
  • Lisa M Wu
  • Sonia Ancoli-Israel, University of California at San Diego
  • ,
  • Jason Chen, Icahn School of Medicine at Mount Sinai
  • ,
  • Ariella Hoffman-Peterson, Icahn School of Medicine at Mount Sinai
  • ,
  • Julia Granski, Icahn School of Medicine at Mount Sinai
  • ,
  • Nina Prescott, Icahn School of Medicine at Mount Sinai
  • ,
  • Alejandro Vega, Icahn School of Medicine at Mount Sinai
  • ,
  • Natalie Stern, Icahn School of Medicine at Mount Sinai
  • ,
  • Gary Winkel, Icahn School of Medicine at Mount Sinai
  • ,
  • William H Redd, Icahn School of Medicine at Mount Sinai

BACKGROUND: Over a third of multiple myeloma (MM) patients report clinical levels of depression during autologous stem cell transplant (ASCT) hospitalization. We report preliminary results from a randomized clinical trial investigating the effect of Programmed Environmental Illumination (PEI) of hospital rooms on depression.

METHODS: Patients (N = 187) scheduled to receive an ASCT were assessed for eligibility. Those who met study eligibility criteria (n = 44) were randomly assigned to one of two PEI conditions involving delivery of either circadian active bright white light (BWL) or circadian inactive dim white light (DWL) throughout the room from 7 to 10 am daily during hospitalization. Patients completed the Center for Epidemiological Studies Depression Scale (CES-D) prior to hospitalization, at days 2 and 7 post-transplant, and on the third day of engraftment.

RESULTS: General linear model analyses revealed no difference between the groups in CES-D total score at baseline (P = 0.7859). A longitudinal linear mixed model analysis revealed a significant interaction between time of assessment and light condition [F(3,107) = 2.90; P = 0.0386; ɳ2 = 0.08)], indicating that PEI prevented the development of depression during hospitalization, with effects reaching significance by the third day of engraftment. At the third day of engraftment, 68.4% of the participants in the DWL comparison condition met the criteria for clinically significant depression compared to 42.1% in the BWL condition.

CONCLUSION: These findings demonstrate that PEI using BWL during MM ASCT hospitalization is effective in reducing the development of depression. Future studies should examine the mechanisms whereby PEI improves depression.

Original languageEnglish
JournalCancer medicine
Pages (from-to)4345-4353
Number of pages9
Publication statusPublished - Sept 2018
Externally publishedYes

Bibliographical note

© 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

    Research areas

  • Depression/diagnosis, Female, Hematopoietic Stem Cell Transplantation/adverse effects, Humans, Lighting/adverse effects, Male, Multiple Myeloma/complications, Risk Factors, Severity of Illness Index, Transplantation, Autologous

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