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Lisa Maria Wu

Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours. / Haldbo-Classen, L; Amidi, A; Wu, L M et al.
In: Clinical and Translational Radiation Oncology, Vol. 31, 11.2021, p. 86-92.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Haldbo-Classen, L, Amidi, A, Wu, LM, Lukacova, S, Oettingen, G, Lassen-Ramshad, Y, Zachariae, R, Kallehauge, JF & Høyer, M 2021, 'Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours', Clinical and Translational Radiation Oncology, vol. 31, pp. 86-92. https://doi.org/10.1016/j.ctro.2021.09.006

APA

Haldbo-Classen, L., Amidi, A., Wu, L. M., Lukacova, S., Oettingen, G., Lassen-Ramshad, Y., Zachariae, R., Kallehauge, J. F., & Høyer, M. (2021). Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours. Clinical and Translational Radiation Oncology, 31, 86-92. https://doi.org/10.1016/j.ctro.2021.09.006

CBE

Haldbo-Classen L, Amidi A, Wu LM, Lukacova S, Oettingen G, Lassen-Ramshad Y, Zachariae R, Kallehauge JF, Høyer M. 2021. Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours. Clinical and Translational Radiation Oncology. 31:86-92. https://doi.org/10.1016/j.ctro.2021.09.006

MLA

Haldbo-Classen, L et al. "Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours". Clinical and Translational Radiation Oncology. 2021, 31. 86-92. https://doi.org/10.1016/j.ctro.2021.09.006

Vancouver

Haldbo-Classen L, Amidi A, Wu LM, Lukacova S, Oettingen G, Lassen-Ramshad Y et al. Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours. Clinical and Translational Radiation Oncology. 2021 Nov;31:86-92. doi: 10.1016/j.ctro.2021.09.006

Author

Haldbo-Classen, L ; Amidi, A ; Wu, L M et al. / Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours. In: Clinical and Translational Radiation Oncology. 2021 ; Vol. 31. pp. 86-92.

Bibtex

@article{9f7871bdb06a4b468b55817d69ce3204,
title = "Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours",
abstract = "Aim: This study aimed to explore associations between radiation dose and patient-reported outcomes in patients with a primary non-glioblastoma brain tumour treated with radiation therapy (RT), with a focus on health-related quality-of-life (HRQoL) and self-reported cognitive function.Methods: In this cross-sectional study, 78 patients who had received RT for a non-glioblastoma primary brain tumour, underwent neuropsychological testing and completed questionnaires on HRQoL, cognitive function, fatigue, depression, anxiety and perceived stress. The study explores the association between HRQoL scores, self-reported cognitive function and radiation doses to total brain, brainstem, hippocampus, thalamus, temporal lobes and frontal lobes. In addition, we examined correlations between neuropsychological test scores and self-reported cognitive function.Results: The median time between RT and testing was 4.6 years (range 1-9 years). Patients who had received high mean radiation doses to the total brain had low HRQoL scores (Cohen's d = 0.50, p = 0.04), brainstem (d = 0.65, p = 0.01) and hippocampus (d = 0.66, p = 0.01). High mean doses to the total brain were also associated with low scores on self-reported cognitive functioning (Cohen's d = 0.64, p = 0.02), brainstem (d = 0.55, p = 0.03), hippocampus (d = 0.76, p < 0.01), temporal lobes (d = 0.70, p < 0.01) and thalamus (d = 0.64, p = 0.01). Self-reported cognitive function correlated well with neuropsychological test scores (correlation range 0.27-0.54.).Conclusions: High radiation doses to specific brain structures may be associated with impaired HRQoL and self-reported cognitive function with potentially negative implications to patients' daily lives. Patient-reported outcomes of treatment-related side-effects and their associations with radiation doses to the brain and its sub-structures may provide important information on radiation tolerance to the brain and sub-structures.",
keywords = "Brain tumor, Cognition, Patient-reported outcomes, Quality of life, Radiation therapy",
author = "L Haldbo-Classen and A Amidi and Wu, {L M} and S Lukacova and G Oettingen and Y Lassen-Ramshad and R Zachariae and Kallehauge, {J F} and M H{\o}yer",
year = "2021",
month = nov,
doi = "10.1016/j.ctro.2021.09.006",
language = "English",
volume = "31",
pages = "86--92",
journal = "Clinical and Translational Radiation Oncology",
issn = "2405-6308",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours

AU - Haldbo-Classen, L

AU - Amidi, A

AU - Wu, L M

AU - Lukacova, S

AU - Oettingen, G

AU - Lassen-Ramshad, Y

AU - Zachariae, R

AU - Kallehauge, J F

AU - Høyer, M

PY - 2021/11

Y1 - 2021/11

N2 - Aim: This study aimed to explore associations between radiation dose and patient-reported outcomes in patients with a primary non-glioblastoma brain tumour treated with radiation therapy (RT), with a focus on health-related quality-of-life (HRQoL) and self-reported cognitive function.Methods: In this cross-sectional study, 78 patients who had received RT for a non-glioblastoma primary brain tumour, underwent neuropsychological testing and completed questionnaires on HRQoL, cognitive function, fatigue, depression, anxiety and perceived stress. The study explores the association between HRQoL scores, self-reported cognitive function and radiation doses to total brain, brainstem, hippocampus, thalamus, temporal lobes and frontal lobes. In addition, we examined correlations between neuropsychological test scores and self-reported cognitive function.Results: The median time between RT and testing was 4.6 years (range 1-9 years). Patients who had received high mean radiation doses to the total brain had low HRQoL scores (Cohen's d = 0.50, p = 0.04), brainstem (d = 0.65, p = 0.01) and hippocampus (d = 0.66, p = 0.01). High mean doses to the total brain were also associated with low scores on self-reported cognitive functioning (Cohen's d = 0.64, p = 0.02), brainstem (d = 0.55, p = 0.03), hippocampus (d = 0.76, p < 0.01), temporal lobes (d = 0.70, p < 0.01) and thalamus (d = 0.64, p = 0.01). Self-reported cognitive function correlated well with neuropsychological test scores (correlation range 0.27-0.54.).Conclusions: High radiation doses to specific brain structures may be associated with impaired HRQoL and self-reported cognitive function with potentially negative implications to patients' daily lives. Patient-reported outcomes of treatment-related side-effects and their associations with radiation doses to the brain and its sub-structures may provide important information on radiation tolerance to the brain and sub-structures.

AB - Aim: This study aimed to explore associations between radiation dose and patient-reported outcomes in patients with a primary non-glioblastoma brain tumour treated with radiation therapy (RT), with a focus on health-related quality-of-life (HRQoL) and self-reported cognitive function.Methods: In this cross-sectional study, 78 patients who had received RT for a non-glioblastoma primary brain tumour, underwent neuropsychological testing and completed questionnaires on HRQoL, cognitive function, fatigue, depression, anxiety and perceived stress. The study explores the association between HRQoL scores, self-reported cognitive function and radiation doses to total brain, brainstem, hippocampus, thalamus, temporal lobes and frontal lobes. In addition, we examined correlations between neuropsychological test scores and self-reported cognitive function.Results: The median time between RT and testing was 4.6 years (range 1-9 years). Patients who had received high mean radiation doses to the total brain had low HRQoL scores (Cohen's d = 0.50, p = 0.04), brainstem (d = 0.65, p = 0.01) and hippocampus (d = 0.66, p = 0.01). High mean doses to the total brain were also associated with low scores on self-reported cognitive functioning (Cohen's d = 0.64, p = 0.02), brainstem (d = 0.55, p = 0.03), hippocampus (d = 0.76, p < 0.01), temporal lobes (d = 0.70, p < 0.01) and thalamus (d = 0.64, p = 0.01). Self-reported cognitive function correlated well with neuropsychological test scores (correlation range 0.27-0.54.).Conclusions: High radiation doses to specific brain structures may be associated with impaired HRQoL and self-reported cognitive function with potentially negative implications to patients' daily lives. Patient-reported outcomes of treatment-related side-effects and their associations with radiation doses to the brain and its sub-structures may provide important information on radiation tolerance to the brain and sub-structures.

KW - Brain tumor

KW - Cognition

KW - Patient-reported outcomes

KW - Quality of life

KW - Radiation therapy

U2 - 10.1016/j.ctro.2021.09.006

DO - 10.1016/j.ctro.2021.09.006

M3 - Journal article

C2 - 34693039

VL - 31

SP - 86

EP - 92

JO - Clinical and Translational Radiation Oncology

JF - Clinical and Translational Radiation Oncology

SN - 2405-6308

ER -