Line Reinert

  1. 2022
  2. Published

    Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen. / Taha, Zaid; Arulanandam, Rozanne; Maznyi, Glib et al.

    In: Molecular Therapy, Vol. 30, No. 9, 09.2022, p. 2998-3016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. Published

    TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection. / van der Sluis, Renée M.; Cham, Lamin B.; Gris-Oliver, Albert et al.

    In: EMBO Journal, Vol. 41, No. 10, e109622, 05.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. Published

    Microglia Activate Early Antiviral Responses upon Herpes Simplex Virus 1 Entry into the Brain to Counteract Development of Encephalitis-Like Disease in Mice. / Katzilieris-Petras, Georgios; Lai, Xin; Rashidi, Ahmad S. et al.

    In: Journal of Virology, Vol. 96, No. 6, e01311-21, 03.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. Published

    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses. / Vila, Isabelle K.; Chamma, Hanane; Steer, Alizée et al.

    In: Cell Metabolism, Vol. 34, No. 1, 01.2022, p. 125-139.e8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. 2021
  7. Published

    A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry. / Valero, Julian; Civit, Laia; Dupont, Daniel M. et al.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 50, e2112942118, 12.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. Published

    B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation. / Green, Kenneth; Wittenborn, Thomas R.; Fahlquist-Hagert, Cecilia et al.

    In: Frontiers in Immunology, Vol. 12, 782558, 12.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    The alpha/b.1.1.7 sars-cov-2 variant exhibits significantly higher affinity for ace-2 and requires lower inoculation doses to cause disease in k18-hace2 mice. / Bayarri-Olmos, Rafael; Johnsen, Laust Bruun; Idorn, Manja et al.

    In: eLife, Vol. 10, e70002, 11.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Published

    Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. / Tomac, Jelena; Mazor, Marija; Lisnić, Berislav et al.

    In: Immunity, Vol. 54, No. 7, 07.2021, p. 1478-1493.e6.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production. / Reinert, Line S; Rashidi, Ahmad S; Tran, Diana N et al.

    In: Journal of Clinical Investigation, Vol. 131, No. 1, e136824, 01.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity. / Fougeroux, Cyrielle; Goksøyr, Louise; Idorn, Manja et al.

    In: Nature Communications, Vol. 12, No. 1, 324, 01.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. 2020
  14. Published

    SARS-CoV-2 evades immune detection in alveolar macrophages. / Dalskov, Louise; Møhlenberg, Michelle; Thyrsted, Jacob et al.

    In: EMBO Reports, Vol. 21, No. 12, e51252, 12.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. Published

    Author Correction : STEEP mediates STING ER exit and activation of signaling (Nature Immunology, (2020), 21, 8, (868-879), 10.1038/s41590-020-0730-5). / Zhang, Bao-cun; Nandakumar, Ramya; Reinert, Line S. et al.

    In: Nature Immunology, Vol. 21, No. 11, 11.2020, p. 1468-1469.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperComment/debate/letter to the editorResearchpeer-review

  16. Published

    Author Correction : SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. / Olagnier, David; Farahani, Ensieh; Thyrsted, Jacob et al.

    In: Nature Communications, Vol. 11, No. 1, 5419, 21.10.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperComment/debate/letter to the editorResearchpeer-review

  17. Published

    SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. / Olagnier, David; Farahani, Ensieh; Thyrsted, Jacob et al.

    In: Nature Communications, Vol. 11, No. 1, 4938, 10.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection. / Bodda, Chiranjeevi; Reinert, Line S.; Fruhwürth, Stefanie et al.

    In: Journal of Experimental Medicine, Vol. 217, No. 7, e20191422, 07.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. Published

    STEEP mediates STING ER exit and activation of signaling. / Zhang, Bao cun; Nandakumar, Ramya; Reinert, Line S. et al.

    In: Nature Immunology, Vol. 21, No. 8, 2020, p. 868-879.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. 2019
  21. Published

    The alternative cap-binding complex is required for antiviral defense in vivo. / Gebhardt, Anna; Bergant, Valter; Schnepf, Daniel et al.

    In: PLOS Pathogens, Vol. 15, No. 12, 1008155, 12.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. Published

    DNA-stimulated cell death : implications for host defence, inflammatory diseases and cancer. / Paludan, Søren R.; Reinert, Line S.; Hornung, Veit.

    In: Nature Reviews Immunology, Vol. 19, No. 3, 01.03.2019, p. 141-153.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  23. 2018
  24. Published

    High-dose vitamin D3 supplementation decreases the number of colonic CD103+ dendritic cells in healthy subjects. / Bak, Nina Friis; Bendix, M; Hald, S et al.

    In: European Journal of Nutrition, Vol. 57, No. 7, 10.2018, p. 2607-2619.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1. / Prabakaran, Thaneas; Bodda, Chiranjeevi; Krapp, Christian et al.

    In: E M B O Journal, Vol. 37, No. 8, E97858, 13.04.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. Published

    STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice. / Skouboe, Morten K; Knudsen, Alice; Reinert, Line S et al.

    In: P L o S Pathogens, Vol. 14, No. 4, e1006976, 02.04.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. 2017
  28. Published

    Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer. / Thomsen, Mathilde Borg Houlberg; Nordentoft, Iver; Lamy, Philippe et al.

    In: Scientific Reports, Vol. 7, No. 1, 15.09.2017, p. 11702.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. 2016
  30. Published

    Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. / Reinert, Line S; Lopušná, Katarína; Winther, Henriette et al.

    In: Nature Communications, Vol. 7, 13348, 10.11.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  31. Published

    Gene-environmental interactions between genetic variants in antiviral response genes and prenatal maternal infections in schizophrenia. / Manikandan, Veera; Reinert, Line; Paludan, Søren Riis et al.

    2016. Poster session presented at American Society of Human Genetics 2016, Vancouver, Canada.

    Research output: Contribution to conferencePosterResearch

  32. Published

    HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. / Christensen, Maria H.; Jensen, Søren B.; Miettinen, Juho J. et al.

    In: The EMBO Journal, Vol. 35, No. 13, 01.07.2016, p. 1385-1399.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  33. Published

    Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection. / Thomsen, Martin K; Nandakumar, Ramya; Stadler, Daniela et al.

    In: Hepatology, Vol. 64, No. 3, 16.06.2016, p. 746-759.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  34. 2015
  35. Published

    An innate antiviral pathway acting before interferons at epithelial surfaces. / Iversen, Marie B; Reinert, Line S; Thomsen, Martin K et al.

    In: Nature Immunology, 30.11.2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  36. Published

    NKT cell activation by local α-galactosylceramide administration decreases susceptibility to HSV-2 infection. / Iversen, Marie Beck; Jensen, Simon Kok; Hansen, Anne Louise et al.

    In: Immunobiology, 21.01.2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  37. Published

    Functional IRF3 deficiency in a patient with herpes simplex encephalitis. / Andersen, Line Lykke; Mørk, Nanna; Reinert, Line S et al.

    In: Journal of Experimental Medicine, Vol. 212, No. 9, 2015, p. 1371-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  38. 2014
  39. Published

    TRAM is required for TLR2 endosomal signaling to type I IFN induction. / Stack, Julianne; Doyle, Sarah L; Connolly, Dympna J et al.

    In: Journal of Immunology, Vol. 193, No. 12, 15.12.2014, p. 6090-102.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. Published

    Innate antiviral signalling in the central nervous system. / Carty, Michael; Reinert, Line; Paludan, Søren R. et al.

    In: Trends in Immunology, Vol. 35, No. 2, 01.02.2014, p. 79-87.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  41. 2013
  42. Published

    Interleukin-21 Receptor Signalling Is Important for Innate Immune Protection against HSV-2 Infections. / Kratholm, Sine K; Iversen, Marie B; Reinert, Line et al.

    In: PLOS ONE, Vol. 8, No. 12, 2013, p. e81790.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  43. 2012
  44. Published

    Antiviral and immunological effects of tenofovir microbicide in vaginal herpes simplex virus 2 infection. / Vibholm, Line; Reinert, Line S; Søgaard, Ole S et al.

    In: AIDS Research and Human Retroviruses, Vol. 28, No. 11, 2012, p. 1404-11.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  45. Published

    TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice. / Reinert, Line S; Harder, Louis; Holm, Christian K et al.

    In: Journal of Clinical Investigation, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  46. 2009
  47. Published

    Innate recognition of intracellular pathogens: detection and activation of the first line of defense. / Rasmussen, Simon B; Reinert, Line; Paludan, Søren R.

    In: A P M I S Supplementum, Vol. 117, No. 5-6, 01.05.2009, p. 323-37.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  48. 2008
  49. Published

    TLR2 and TLR9 Synergistically Control Herpes Simplex Virus Infection in the Brain. / Sørensen, Louise Nørgaard; Reinert, Line; Malmgaard, Lene et al.

    In: Journal of Immunology, Vol. 181, 2008, p. 8604-12.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  50. Published

    TLR2 and TLR9 synergistically control herpes simplex virus infection in the brain. / Sørensen, Louise N; Reinert, Line S; Malmgaard, Lene et al.

    In: Journal of Immunology, Vol. 181, No. 12, 2008, p. 8604-12.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  51. 2007
  52. Published

    Erratum : Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage (Oncogene (2007) 26 (2283-2289) DOI: 10.1038/sj.onc.1210030). / Nandi, S.; Reinert, L. S.; Hachem, A. et al.

    In: Oncogene, Vol. 26, No. 18, 19.04.2007.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperComment/debate/letter to the editorResearchpeer-review

  53. Published

    Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations : a synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer. / Nielsen, Karsten Bork; Sørensen, Suzette; Cartegni, Luca et al.

    In: American Journal of Human Genetics, Vol. 80, No. 3, 01.03.2007, p. 416-432.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  54. Published

    Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage. / Nandi, S; Reinert, Line; Hachem, A et al.

    In: Oncogene, Vol. 26, 2007, p. 2283-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  55. 2006
  56. Published

    A novel splice donor site in the gag-pol gene is required for HIV-1 RNA stability. / Lützelberger, Martin; Reinert, Line S; Das, Atze T et al.

    In: Journal of Biological Chemistry, Vol. 281, No. 27, 07.07.2006, p. 18644-18651.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  57. Published

    Expression of DNA mismatch repair proteins in transformed non-Hodgkin's lymphoma: relationship to smoking. / Nandi, S; Yu, J; Reinert, Line et al.

    In: Leukemia and Lymphoma, Vol. 47, 2006, p. 1806-12.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  58. Published

    MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles. / Reinert, Line; Shi, B; Nandi, S et al.

    In: Cancer Research, Vol. 66, 2006, p. 8994-9001.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  59. 2004
  60. Published

    Homozygosity for a severe novel medium-chain acyl-CoA dehydrogenase (MCAD) mutation IVS3-1G > C that leads to introduction of a premature termination codon by complete missplicing of the MCAD mRNA and is associated with phenotypic diversity ranging from sudden neonatal death to asymptomatic status. / Korman, Stanley H.; Gutman, Alisa; Brooks, Rivka et al.

    In: Molecular Genetics and Metabolism, Vol. 82, No. 2, 01.06.2004, p. 121-129.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  61. Published

    Homozygosity for a severe novel medium-chain acyl-CoA dehydrogenase (MCAD) mutation IVS3-1G [Formula: see text] C that leads to introduction of a premature termination codon by complete missplicing of the MCADmRNA and is associated with phenotypic diversity ranging from sudden neonatal death to asymptomatic status. / Korman, S.H.; Gutman, A.; Brooks, R. et al.

    In: Mol. Genet, No. Metab 82, 2004, p. 121-129.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  62. 2003
  63. Published

     A missense mutation found in patients with MCAD deficiency inactivates an exonic splicing enhancer in the MCAD gene. / Nielsen, Karsten Bork; Sinnathamby, Thayline; Cartegni, Luca et al.

    2003. Poster session presented at Annual Meeting of the RNA society, Wien.

    Research output: Contribution to conferencePosterResearch