Department of Management

Liisa Lähteenmäki

Psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Leila J. Karhunen, University of Eastern Finland, Finland
  • Kristiina R. Juvonen, University of Eastern Finland, Finland
  • Sanna M. Flander, University of Eastern Finland, Finland
  • Kirsi-Helena Liukkonen, VTT Technical Research Centre of Finland, Finland
  • Liisa Lähteenmäki
  • Maritta Siloaho, University of Eastern Finland, Finland
  • David E. Laaksonen, Kuopio University Hospital, Finland
  • Karl-Heinz Herzig, Kuopio University Hospital, Finland
  • Matti I. Uusitupa, University of Eastern Finland, Finland
  • Kaisa S. Poutanen, University of Eastern Finland, Finland
  • Department of Marketing and Statistics
  • MAPP - Centre for Research on Customer Relations in the Food Sector
Dietary fiber (DF) and protein are essential constituents of a healthy diet and are well known for their high satiety impact. However, little is known about their influence on postprandial gastrointestinal (GI) peptide release. Our aim in this single-blind, randomized, cross-over study was to investigate the effects of DF and/or protein enrichments on satiety-related metabolic and hormonal responses. Sixteen healthy, nonobese volunteers participated in the study and ingested 1 of 5 isoenergetic test meals in a randomized order on separate days. The test meals were as follows: 1) low in protein (2.8 g) and fiber (7.6 g); 2) low in protein (2.6 g) and high in soluble fiber (psyllium, 23.0 g); 3) high in protein (soy, 19.7 g) and low in fiber (6.2 g); 4) high in protein (18.4 g) and fiber (23.0 g); and 5) white wheat bread. Serum insulin and plasma glucose, ghrelin, glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) concentrations were determined for 2 h following the meals. In addition, hunger and satiety ratings were collected. Postprandial glucose, insulin, ghrelin, GLP-1, and PYY responses all differed among the meals (P = 0.05). Fiber-enriched meals decreased glucose, insulin, ghrelin, and PYY responses; in addition, PYY secretion was prolonged compared with the other meals. The postprandial GLP-1 concentration was significantly suppressed after a fiber- and protein-rich meal, in contrast to the initial increases following the other meals. However, postprandial ratings of appetite were mostly similar after the test meals. In conclusion, solid meals enriched with psyllium fiber strongly modified postprandial signals arising from the GI tract.
Original languageEnglish
JournalJournal of Nutrition
Volume140
Issue4
Pages (from-to)737-744
Number of pages8
ISSN0022-3166
DOIs
Publication statusPublished - 2010

    Research areas

  • MAPP

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