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Center for Music in the Brain

Leonardo Bonetti

Brain predictive coding processes are associated to COMT gene Val158Met polymorphism

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Brain predictive coding processes are associated to COMT gene Val158Met polymorphism. / Bonetti, L.; Bruzzone, S. E.P.; Sedghi, N. A. et al.

In: NeuroImage, Vol. 233, 117954, 06.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Vancouver

Bonetti L, Bruzzone SEP, Sedghi NA, Haumann NT, Paunio T, Kantojärvi K et al. Brain predictive coding processes are associated to COMT gene Val158Met polymorphism. NeuroImage. 2021 Jun;233:117954. doi: 10.1016/j.neuroimage.2021.117954

Author

Bonetti, L. ; Bruzzone, S. E.P. ; Sedghi, N. A. et al. / Brain predictive coding processes are associated to COMT gene Val158Met polymorphism. In: NeuroImage. 2021 ; Vol. 233.

Bibtex

@article{eb2abbc79b5a4505a3defa2aea920465,

title = "Brain predictive coding processes are associated to COMT gene Val158Met polymorphism",

abstract = "Predicting events in the ever-changing environment is a fundamental survival function intrinsic to the physiology of sensory systems, whose efficiency varies among the population. Even though it is established that a major source of such variations is genetic heritage, there are no studies tracking down auditory predicting processes to genetic mutations. Thus, we examined the neurophysiological responses to deviant stimuli recorded with magnetoencephalography (MEG) in 108 healthy participants carrying different variants of Val158Met single-nucleotide polymorphism (SNP) within the catechol-O-methyltransferase (COMT) gene, responsible for the majority of catecholamines degradation in the prefrontal cortex. Our results showed significant amplitude enhancement of prediction error responses originating from the inferior frontal gyrus, superior and middle temporal cortices in heterozygous genotype carriers (Val/Met) vs homozygous (Val/Val and Met/Met) carriers. Integrating neurophysiology and genetics, this study shows how the neural mechanisms underlying optimal deviant detection vary according to the gene-determined cathecolamine levels in the brain.",

keywords = "Catechol-O-methyltransferase (COMT) gene, Magnetoencephalography (MEG), Mismatch negativity (MMN), Predictive coding",

author = "L. Bonetti and Bruzzone, {S. E.P.} and Sedghi, {N. A.} and Haumann, {N. T.} and T. Paunio and K. Kantoj{\"a}rvi and M. Kliuchko and P. Vuust and E. Brattico",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = jun,

doi = "10.1016/j.neuroimage.2021.117954",

language = "English",

volume = "233",

journal = "NeuroImage",

issn = "1053-8119",

publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Brain predictive coding processes are associated to COMT gene Val158Met polymorphism

AU - Bonetti, L.

AU - Bruzzone, S. E.P.

AU - Sedghi, N. A.

AU - Haumann, N. T.

AU - Paunio, T.

AU - Kantojärvi, K.

AU - Kliuchko, M.

AU - Vuust, P.

AU - Brattico, E.

PY - 2021/6

Y1 - 2021/6

N2 - Predicting events in the ever-changing environment is a fundamental survival function intrinsic to the physiology of sensory systems, whose efficiency varies among the population. Even though it is established that a major source of such variations is genetic heritage, there are no studies tracking down auditory predicting processes to genetic mutations. Thus, we examined the neurophysiological responses to deviant stimuli recorded with magnetoencephalography (MEG) in 108 healthy participants carrying different variants of Val158Met single-nucleotide polymorphism (SNP) within the catechol-O-methyltransferase (COMT) gene, responsible for the majority of catecholamines degradation in the prefrontal cortex. Our results showed significant amplitude enhancement of prediction error responses originating from the inferior frontal gyrus, superior and middle temporal cortices in heterozygous genotype carriers (Val/Met) vs homozygous (Val/Val and Met/Met) carriers. Integrating neurophysiology and genetics, this study shows how the neural mechanisms underlying optimal deviant detection vary according to the gene-determined cathecolamine levels in the brain.

AB - Predicting events in the ever-changing environment is a fundamental survival function intrinsic to the physiology of sensory systems, whose efficiency varies among the population. Even though it is established that a major source of such variations is genetic heritage, there are no studies tracking down auditory predicting processes to genetic mutations. Thus, we examined the neurophysiological responses to deviant stimuli recorded with magnetoencephalography (MEG) in 108 healthy participants carrying different variants of Val158Met single-nucleotide polymorphism (SNP) within the catechol-O-methyltransferase (COMT) gene, responsible for the majority of catecholamines degradation in the prefrontal cortex. Our results showed significant amplitude enhancement of prediction error responses originating from the inferior frontal gyrus, superior and middle temporal cortices in heterozygous genotype carriers (Val/Met) vs homozygous (Val/Val and Met/Met) carriers. Integrating neurophysiology and genetics, this study shows how the neural mechanisms underlying optimal deviant detection vary according to the gene-determined cathecolamine levels in the brain.

KW - Catechol-O-methyltransferase (COMT) gene

KW - Magnetoencephalography (MEG)

KW - Mismatch negativity (MMN)

KW - Predictive coding

UR - http://www.scopus.com/inward/record.url?scp=85102900264&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2021.117954

DO - 10.1016/j.neuroimage.2021.117954

M3 - Journal article

C2 - 33716157

AN - SCOPUS:85102900264

VL - 233

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

M1 - 117954

ER -