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Lene Pedersen

Pathogenicity of BALB/c-derived N-tropic murine leukemia viruses

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  • L Pedersen
  • P G Strauss, Denmark
  • J Schmidt, Denmark
  • A Luz, Denmark
  • V Erfle, Denmark
  • Poul Jørgensen, Denmark
  • N O Kjeldgaard, Denmark
  • F S Pedersen, Denmark
  • Department of Molecular Biology
N-tropic murine leukemia viruses have been observed in connection with radiation-induced osteosarcomagenesis in BALB/c mice. We have investigated the bone disease-inducing potential of molecularly cloned, BALB/c-derived N-tropic viruses in the random-bred NMRI mouse strain. The germ-line virus and an exogenous virus isolate were found to induce high incidences of osteopetrosis and lymphomas and a lower incidence of osteomas. Two viruses derived from somatically acquired proviruses of independent radiation-induced osteosarcomas induced lower incidence of osteopetrosis and lymphomas. Nucleotide sequence analysis of the long terminal repeat regions and RNase T1 fingerprint analysis revealed only few differences between the isolates. The possible involvement of N-tropic murine leukemia viruses in radiation-induced osteosarcomagenesis in the BALB/c mouse strain is discussed.
Original languageEnglish
JournalVirology
Volume179
Issue2
Pages (from-to)931-5
Number of pages4
ISSN0042-6822
Publication statusPublished - 1990

    Research areas

  • Animals, Base Sequence, Cloning, Molecular, Leukemia Virus, Murine, Mice, Mice, Inbred BALB C, Nucleotide Mapping, Osteosarcoma, RNA, Viral, Sarcoma, Experimental

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