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Lene Pedersen

Molecular cloning of osteoma-inducing replication-competent murine leukemia viruses from the RFB osteoma virus stock

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  • Lene Pedersen
  • Werner Behnisch, Institute für Virologie, GSF-Forschungszentrum für Umwelt und Gesundheit GmbH, Germany
  • Jörg Schmidt, Institute für Virologie, GSF-Forschungszentrum für Umwelt und Gesundheit GmbH, Germany
  • Arne Luz, Institute für Pathologie, GSF-Forschungszentrum für Umwelt und Gesundheit GmbH, Germany
  • Finn Skou Pedersen
  • Volker Erfle, Institute für Virologie, GSF-Forschungszentrum für Umwelt und Gesundheit GmbH, Germany
  • P Günther Strauss, Institute für Virologie, GSF-Forschungszentrum für Umwelt und Gesundheit GmbH, Germany
We report the molecular cloning of two replication-competent osteoma-inducing murine leukemia viruses from the RFB osteoma virus stock (M. P. Finkel, C. A. Reilly, Jr., B. O. Biskis, and I. L. Greco, p. 353-366, in C. H. G. Price and F. G. M. Ross, ed., Bone--Certain Aspects of Neoplasia, 1973). Like the original RFB osteoma virus stock, viruses derived from the molecular RFB clones induced multiple osteomas in mice of the CBA/Ca strain. The cloned RFB viruses were indistinguishable by restriction enzyme analysis and by nucleotide sequence analysis of their long-terminal-repeat regions and showed close relatedness to the Akv murine leukemia virus.
Original languageEnglish
JournalJournal of Virology
Volume66
Issue10
Pages (from-to)6186-6190
Number of pages5
ISSN0022-538X
Publication statusPublished - Oct 1992

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