Aarhus University Seal / Aarhus Universitets segl

Lene Pedersen

Akv murine leukemia virus enhances bone tumorigenesis in hMT-c-fos-LTR transgenic mice

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Jörg Schmidt, GSF-Institut für Molekulare Virologie, Germany
  • Vera Krump-Konvalinkova, ITRI-TNO, Netherlands
  • Arne Luz, GSF-Institut für Pathologie, Germany
  • Regina Goralczyk, GSF-Institut für Molekulare Virologie, Germany
  • Gertraud Snell, GSF-Institut für Molekulare Virologie, Germany
  • Susanne Wendel, GSF-Institut für Molekulare Virologie, Germany
  • Sylvia Dorn, GSF-Institut für Molekulare Virologie, Germany
  • Lene Pedersen
  • P Günther Strauss, GSF-Institut für Molekulare Virologie, Germany
  • Volker Erfle, GSF-Institut für Molekulare Virologie, Germany
hMt-c-fos-LTR transgenic mice (U. Rüther, D. Komitowski, F. R. Schubert, and E. F. Wagner. Oncogene 4, 861–865, 1989) developed bone sarcomas in 20% (3/15) of females at 448 ± 25 days and in 8% (1/12) of males at 523 days. After infection of newborns with Akv, an infectious retrovirus derived from the ecotropic provirus of the AKR mouse, 69% (20/28) of female animals and 83% (24/29) of males developed malignant fibrous-osseous tumors. The tumors in infected transgenics developed with higher frequency and a 200-days shorter mean tumor latency period. The hMt-c-fos-LTR transgene was expressed in all the fibrous-osseous tumors. They also showed newly integrated Akv proviruses, but in most tumors Akv was detected and expressed in only a small number of the tumor cells. Wild-type C3H mice infected with Akv developed benign osteomas with an incidence of 33% and a latency period of 474 days. The data indicate that Akv exerts distinct pathogenic effects on the skeleton. In hMt-c-fos-LTR transgenic mice, predisposed to bone sarcomagenesis, Akv acts synergistically with the fos transgene, resulting in the development of fibrous-osseous tumors
Original languageEnglish
JournalVirology
Volume206
Issue1
Pages (from-to)85-92
Number of pages8
ISSN0042-6822
DOIs
Publication statusPublished - 10 Jan 1995

See relations at Aarhus University Citationformats

ID: 48423739