Mice knocked out for the primary brain calcification - associated gene Slc20a2 show unimpaired pre-natal survival but retarded growth and nodules in the brain that grow and calcify over time. / Jensen, Nina; Schrøder, Henrik Daa; Kildall Hejbøl, Eva; Thomsen, Jesper Skovhus; Brüel, Annemarie; Larsen, Frederik; Vinding, Mikkel C.; Orlowski, Dariusz; Füchtbauer, Ernst-Martin; Oliveira, João Ricardo M; Pedersen, Lene.
In: American Journal of Pathology, Vol. 188, No. 8, 08.2018, p. 1865-1881.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Primary Brain Calcification Causal PiT2 Transport-Knockout Variants can Exert Dominant Negative Effects on Wild-Type PiT2 Transport Function in Mammalian Cells. / Larsen, Frederik; Jensen, Nina; Autzen, Jacob Kwasi; Kongsfelt, Iben Boutrup; Pedersen, Lene.
In: Journal of Molecular Neuroscience, Vol. 61, No. 2, 2017, p. 215-220.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Type III sodium-dependent inorganic phosphate transporters in health and disease. / Pedersen, Lene.
2016. Abstract from The 48th Sandbjerg Meeting on Membrane Transport, Sønderborg, Denmark.Research output: Contribution to conference › Conference abstract for conference › Research
Slc20a2 is critical for maintaining a physiologic inorganic phosphate level in cerebrospinal fluid. / Jensen, Nina; Autzen, Jacob Kwasi; Pedersen, Lene.
In: Neurogenetics, Vol. 17, No. 2, 2016, p. 125-130.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
A mouse model for cerebrovascular calcification. / Jensen, Nina; Schrøder, Henrik Daa; Hejbøl, Eva Kildall; Thomsen, Jesper Skovhus; Brüel, Annemarie; Larsen, Frederik; Füchtbauer, Ernst-Martin; Oliveira, João Ricardo M; Pedersen, Lene.
2015. Poster session presented at NeuroD2 symposium: Mechanisms in Neurodevelopment and Neurodegeneration — From Molecules to Medicine, Aarhus, Denmark.Research output: Contribution to conference › Poster › Research
An impaired phosphate transporter causes vascular calcification in the brain. / Jensen, Nina; Schrøder, Henrik Daa ; Hejbøl, Eva Kildall ; Thomsen, Jesper Skovhus; Brüel, Annemarie; Larsen, Frederik T.; Füchtbauer, Ernst-Martin; Oliveira, João Ricardo M; Pedersen, Lene.
2014. Abstract from 4th Cold Spring Harbor conference on Blood Brain Barrier, Cold Spring Harbor, United States.Research output: Contribution to conference › Conference abstract for conference › Research
A mouse model for primary familial brain calcification. / Jensen, Nina; Schrøder, Henrik Daa; Kildall Hejbøl, Eva; Thomsen, Jesper Skovhus; Brüel, Annemarie; Larsen, Frederik T.; Füchtbauer, Ernst-Martin; Oliveira, João Ricardo M; Pedersen, Lene.
2014. Poster session presented at Brain Prize Meeting 2014, Middelfart, Denmark.Research output: Contribution to conference › Poster › Research
High levels of the type III inorganic phosphate transporter PiT1 (SLC20A1) can confer faster cell adhesion. / Kongsfelt, Iben Boutrup; Byskov, Kristina; Pedersen, Lasse Ebdrup; Pedersen, Lene.
In: Experimental Cell Research, No. 326, 01.08.2014, p. 57.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
First Report of a De Novo Mutation at SLC20A2 in a Patient with Brain Calcification. / Ferreira, J B; Pimentel, L; Keasey, M P; Lemos, R R; Santos, L M; Oliveira, M F; Santos, S; Jensen, Nina; Teixeira, K; Pedersen, Lene; Rocha, C R; Dias da Silva, M R; Oliveira, J R M.
In: Journal of Molecular Neuroscience, Vol. 54, No. 4, 01.12.2014, p. 748-751.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Loss of function of Slc20a2 associated with familial idiopathic basal ganglia calcification in humans causes brain calcifications in mice. / Jensen, Nina; Daa Schrøder, Henrik; Kildall Hejbøl, Eva ; Füchtbauer, Ernst-Martin; de Oliveira, João Ricardo Mendes ; Pedersen, Lene.
In: Journal of Molecular Neuroscience, Vol. 51, No. 3, 08.2013, p. 994-999.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Regulation of cell proliferation and cell density by the inorganic phosphate transporter PiT1. / Byskov, Kristina; Jensen, Nina; Kongsfelt, Iben Boutrup; Wielsøe, Maria; Pedersen, Lasse Ebdrup; Haldrup, Christa; Pedersen, Lene.
In: Cell Division, Vol. 7, 06.03.2012, p. 7.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Practical Course in Molecular Cell Biology. / Pedersen, Lene; Hansen, Mariann Fagernæs; Pakula, Malgorzata Maria; Lassen, Louise Berkhoudt; Dillschneider, Philipp; marlar, saw; Bechstein, Stefanie; Kromann-Hansen, Tobias; Koffman, Jennifer Skaarup; Torvund, Julie; Wolf, Gernot; Domanski, Michal; Kousted, Tina Mostrup; Nejsum, Lene Niemann; Sørensen, Hans Peter; Schmitt-John, Thomas; Andreasen, Peter; Martensen, Pia Møller.
2011.Research output: Book/anthology/dissertation/report › Compendium/lecture notes › Education
Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of life. / Bøttger, Pernille; Pedersen, Lene.
In: B M C Biochemistry, Vol. 12, No. 21, 17.05.2011.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Human Cord Blood Progenitors with High Aldehyde Dehydrogenase Activity Improve Vascular Density in a Model of Acute Myocardial Infarction. / Søndergaard, Claus S; Hess, David A; Maxwell, Dustin J; Weinheimer, Carla; Rosová, Ivana; Creer, Michael H; Piwnica-Worms, David; Kovacs, Attila; Pedersen, Lene; Nolta, Jan A.
In: Journal of Translational Medicine, Vol. 8, 2010, p. 24.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Practical course in Molecular Cell Biology. / Pedersen, Lene; Pedersen, Lasse Ebdrup; Bøtkjær, Kenneth Alrø; Vestergaard, Anna Lindeløv; Ward, Sarah; Andersen, Lisbeth Moreau; Mikkelsen, Jakob Hauge; Bechstein, Stefanie; Lassen, Louise Berkhoudt; Liu, Zhou; Beer, Christiane; Chen, Zhou; Lykke-Andersen, Søren; Gao, Shan; Sørensen, Hans Peter; Duch, Mogens R.; Schmitt-John, Thomas; Andreasen, Peter; Martensen, Pia Møller.
1. ed. Århus, 2009. 61 p.Research output: Book/anthology/dissertation/report › Compendium/lecture notes › Education
Preloading Potential of Retroviral Vectors Is Packaging Cell Clone Dependent and Centrifugation onto CH-296 Ensures Highest Transduction Efficiency. / Søndergaard, Claus Svane; Haldrup, Christa; Beer, Christiane; Andersen, Bente; Kohn, Donald B.; Pedersen, Lene.
In: Human Gene Therapy, Vol. 20, No. 4, 2009, p. 337-49.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Minimal engraftment of human CD34+ cells mobilized from healthy donors in the infarcted heart of athymic nude rats. / Søndergaard, Claus Svane; Bonde, Jesper; Dagnæs-Hansen, Frederik; Nielsen, Jan Møller; Zachar, Vladimir; Holm, Mette Skov; Hokland, Peter; Pedersen, Lene.
In: Stem Cells and Development, Vol. 18, No. 6, 2009, p. 845-856.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Human Cord Blood Progenitors with High Aldehyde Dehydrogenase Activity Improve Vascular Density in a Model of Acute Myocardial Infarction. / Søndergaard, Claus Svane; Hess, David; Maxwell, Dustin; Rosova, Ivana; Weinheimer, Carla; Kovacs, Attila; Creer, Michael; Piwnica-Worms, David; Pedersen, Lene; Nolta, Jan.
In: Blood, No. 112, 2008, p. 2895.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research
Role of type III NaPi transporter(s) in osteoblastic differentiation. / Haldrup, Christa; B. Nielsen, Lotte; Lykke, Jeanette; Pedersen, Lene.
In: Journal of Bone and Mineral Research, Vol. 22, 2007, p. S371.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research
Matrix fibronectin binds gammaretrovirus and assists in entry - new light on viral infections. / Beer, Christiane; Pedersen, Lene.
In: J. Virol., Vol. 81, No. 15, 2007, p. 8247-8257.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Human ALDH high stem cells from umbilical cord blood home to the heart after IV injection and have minimal therapeutic benefit in an immune deficient mouse model of acute myocardial infarction. / Søndergaard, Claus Svane; Maxwell, Dustin; Hess, Dave; Weinheimer, Carla; Rosova, Ivana; Creer, Michael; Piwnica-Worms, Dave; Pedersen, Lene; Kovacs, Attila; Nolta, Jan.
2006. Poster session presented at International Society for Stem Cell Research 4th Annual Meeting in Toronto, Toronto, Canada.Research output: Contribution to conference › Poster › Research
Transplantation of human CD34+ cells mobilized from healthy donors to the infarcted heart of athymic nude rats does not lead to long term engraftment of human cells. / Søndergaard, Claus Svane; Bonde, Jesper; Dagnæs-Hansen, Frederik; Nielsen, Jan Møller; Zachar, Vladimir; Holm, Mette; Hokland, Peter; Falk, Erling; Pedersen, Lene.
2006. Poster session presented at International Society for Cellular Therapy, 12th Annual Meeting, Berlin, Germany.Research output: Contribution to conference › Poster › Research
Cellular down-regulation of the type III sodium-dependent inorganic phosphate transporter, PiT2, in response to hyperphosphatemic conditions. / Bøttger, Pernille; Pedersen, Lene.
2006. Poster session presented at Ph.D. day 2006, Aarhus, Denmark.Research output: Contribution to conference › Poster › Research
Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2. / Bøttger, Pernille; Hede, Susanne E.; Grunnet, Morten; Høyer, Boy; Klærke, Dan A.; Pedersen, Lene.
In: American Journal of Physiology: Cell Physiology, Vol. 291, 2006, p. 1377-1387.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Ven og fjende - om fosfors to ansigter. / Bøttger, Pernille; Pedersen, Lene.
In: Aktuel Naturvidenskab, Vol. 6, 2006, p. 21-23.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Communication
Amphotropic murine leukemia virus is preferentially attached to cholesterol-rich microdomains after binding to mouse fibroblasts. / Beer, Christiane; Pedersen, Lene.
In: Virol. J., Vol. 2, No. 21, 2006.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
The role of caveolae and fibronectin in amphotropic murine leukaemia virus infection. / Beer, Christiane; Andersen, D. S.; Lykke, J.; Pedersen, Lene.
2005. Paper presented at ELSO 2005 "Frontiers of cellular, developmental and molecular biology", Dresden, Germany.Research output: Contribution to conference › Paper › Research
Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveal two related signature sequences harboring highly conserved aspartic acids critical for sodium-dependent phosphate transport function of human PiT2. / Bøttger, Pernille; Pedersen, Lene.
In: F E B S Journal, Vol. 272, 2005, p. 3060-3074.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Amphotropic murine leukaemia virus envelope protein is associated with cholesterol-rich microdomains. / Beer, Christiane; Pedersen, Lene; Wirth, M.
In: Virol. J., Vol. 2, 2005, p. 36.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Caveolae-dependent endocytic entry of amphotropic murine leukemia virus. / Beer, Christiane; Andersen, D. S.; Rojek, A.; Pedersen, Lene.
In: J. Virol., Vol. 79, 2005, p. 10776-10787.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
A-MLV receptor Pit2 associates directly with caveolin-1; implications for A-MLV entry. / Beer, C.; Andersen, D.S.; Lykke, J.; Pedersen, Lene.
2004. Paper presented at Cold Spring Harbor Laboratories, Cold Spring Harbor, N.Y., May 25-30, .Research output: Contribution to conference › Paper › Research
Efficiency of preloading of retroviral vectors without fibronectin peptide CH-296 is packing cell clone dependent. / Søndergaard, C.S.; Haldrup, C.; Pedersen, Lene.
In: Molecular Therapy, Vol. 9, 2004, p. 279-279.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
The central half of Pit2 is not required for its function as a retroviral receptor. / Bøttger, Pernille; Pedersen, Lene.
In: J. Virol., Vol. 78, 2004, p. 9564-9567.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Cellular regulation of the type III sodium-dependent phosphate transporter, Pit2, in response to hyperphosphatemic conditions. / Bøttger, Pernille; Pedersen, Lene.
2003. Poster session presented at Scandinavian Congress of Physiology and Pharmacology, Odense, Denmark.Research output: Contribution to conference › Poster › Research
Structural requirements for retroviral entry via type III sodium-dependent phosphate transporters. / Bøttger, Pernille; Pedersen, Lene.
2002. Poster session presented at The 2002 International Workshop on Retroviral Pathogenesis, Indian Wells, CA, United States.Research output: Contribution to conference › Poster › Research
Overexpression of gibbon ape leukemia viral (GALV) receptor on human CD34+ cells increases gene transfer mediated by GALV pseudotyped vectors. / Relander, T.; Brun, A.; Olsson, K.; Pedersen, Lene; Richter, J.
In: Molecular Therapy, Vol. 6, 2002, p. 400-406.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
A transmissible human endogenous retrovirus. / Christensen, T.; Pedersen, Lene; Sørensen, P.D.; Møller-Larsen, A.
In: AIDS Research and Human Retroviruses, Vol. 18, 2002, p. 861-866.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
A transmissible human endogenous retrovirus. / Christensen, T.; Pedersen, Lene; Sørensen, P.D.; Møller-Larsen, A.
In: AIDS Research and Human Retroviruses, Vol. 18, 2002, p. 861-866.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function. / Bøttger, Pernille; Pedersen, Lene.
In: Journal of Biological Chemistry, Vol. 227, 2002, p. 42721-42747.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
No correlation between retroviral receptor function and transport function of retroviral receptor PiT2. / Bøttger, Pernille; Pedersen, Lene.
2001. Poster session presented at Retroviruses, Cold Spring Harbor laboratories, NY, United States.Research output: Contribution to conference › Poster › Research
Two glutamates critical for NaPi transport function revealed by exploring the dual functions of Pit2. / Bøttger, Pernille; Pedersen, Lene.
2001. Poster session presented at Scandinavian Physiological Society meeting, Aarhus, Denmark.Research output: Contribution to conference › Poster › Research
Expression of type III sodium-dependent transporters/retroviral receptors mRNAs during osteoblast differentiation. / Nielsen, L.B.; Pedersen, F.S.; Pedersen, Lene.
In: Bone, Vol. 28, 2001, p. 160-166.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Green fluorescent protein retroviral vector: Generation of high-titer producer cells and virus supernatant. / Uckert, W.; Pedersen, Lene; Günzburg, W.; Walther, W. (Editor); Stein, U. (Editor).
Methods in Molecular Medicine: Gene Therapy of Cancer: Methods and Protocols. 35. ed. Totawa, NJ : Humana Press Inc, 2000. p. 275-285.Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research
Efficient gene transfer into primary human CD8+ T Lymphocytes by MuLV-10A1 retrovirus pseudotype. / Uckert, W.; Becker, C.; Gladow, M.; Klein, D.; Kammertoens, T.; Pedersen, Lene; Blankenstein, T.
In: Hum. Gene Ther., Vol. 11, 2000, p. 1005-1014.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
A 13 amino acid Pit-1 specific loop 4 sequence confers feline leukemia virus subgroup B receptor function upon Pit2. / Dreyer, K.; Pedersen, F.S.; Pedersen, Lene.
In: J. Virol., Vol. 74, 2000, p. 2926-2929.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Amphotropic murine leukemia virus entry is determined by specific combinations of residues from receptor loops 2 and 4. / Lundorf, Mikkel; Pedersen, Finn Skou; O'Hara, Bryan; Pedersen, Lene.
In: Journal of Virology, Vol. 73, No. 4, 1999, p. 3169-3175.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
RNA levels of human retrovirus receptors Pit1 and Pit2 do not correlate with infectibility by three retroviral vector pseudotypes. / Uckert, Wolfgang; Willimsky, Gerald; Pedersen, Finn Skou; Blankenstein, Thomas; Pedersen, Lene.
In: Human Gene Therapy, Vol. 9, No. 17, 20.03.1998, p. 2619-2627.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Single Amino Acid Insertion in Loop 4 Confers Amphotropic Murine Leukemia Virus Receptor Function upon Murine Pit1. / Lundorf, Mikkel D.; Pedersen, Finn Skou; O'Hara, Bryan ; Pedersen, Lene.
In: Journal of Virology, Vol. 75, No. 5, 05.1998, p. 4524-4527.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Mapping of a major osteomagenic determinant of murine leukemia virus RFB-14 to non-long terminal repeat sequences. / Østergaard, Mette; Pedersen, Lene; Schmidt, Jörg; Luz, Arne; Lovmand, Jette; Erfle, Volker; Pedersen, Finn Skou.
In: Journal of Virology, Vol. 71, No. 1, 01.1997, p. 645-649.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Fungal phosphate transporter serves as a receptor backbone for gibbon ape leukemia virus. / Pedersen, Lene; van Zeijl, Marja; Johann, Stephen V; O'Hara, Bryan.
In: Journal of Virology, Vol. 71, No. 10, 10.1997, p. 7619-7622.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Akv murine leukemia virus enhances bone tumorigenesis in hMT-c-fos-LTR transgenic mice. / Schmidt, Jörg; Krump-Konvalinkova, Vera; Luz, Arne; Goralczyk, Regina; Snell, Gertraud; Wendel, Susanne; Dorn, Sylvia; Pedersen, Lene; Strauss, P Günther; Erfle, Volker.
In: Virology, Vol. 206, No. 1, 10.01.1995, p. 85-92.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Chimeras of receptors for gibbon ape leukemia virus/feline leukemia virus B and amphotropic murine leukemia virus reveal different modes of receptor recognition by retrovirus. / Pedersen, Lene; Johann, Stephen V; van Zeijl, Marja; Pedersen, Finn Skou; O'Hara, Bryan.
In: Journal of Virology, Vol. 69, No. 4, 04.1995, p. 2401-2405.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
A correlation between dexamethasone inducibility and basal expression levels of retroviral vector proviruses. / Duch, M; Paludan, K; Lovmand, J; Pedersen, L; Jørgensen, Poul; Pedersen, F S.
In: Nucleic Acids Research, Vol. 21, No. 20, 1993, p. 4777-82.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Molecular cloning of osteoma-inducing replication-competent murine leukemia viruses from the RFB osteoma virus stock. / Pedersen, Lene; Behnisch, Werner; Schmidt, Jörg; Luz, Arne; Pedersen, Finn Skou; Erfle, Volker; Strauss, P Günther.
In: Journal of Virology, Vol. 66, No. 10, 10.1992, p. 6186-6190.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Pathogenicity of BALB/c-derived N-tropic murine leukemia viruses. / Pedersen, L; Strauss, P G; Schmidt, J; Luz, A; Erfle, V; Jørgensen, Poul; Kjeldgaard, N O; Pedersen, F S.
In: Virology, Vol. 179, No. 2, 1990, p. 931-5.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Determination of transient or stable neo expression levels in mammalian cells. / Duch, M; Paludan, K; Pedersen, L; Jørgensen, Poul; Kjeldgaard, N O; Pedersen, F S.
In: Gene, Vol. 95, No. 2, 1990, p. 285-8.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Amplification of endogenous proviral MuLV sequences in radiation-induced osteosarcomas. / Strauss, P G; Schmidt, Jörg; Pedersen, Lene; Erfle, Volker.
In: International Journal of Cancer, Vol. 41, No. 4, 15.04.1988, p. 616-621.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review