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Lene Pedersen

Associate professor

Profile photoLene Pedersen, Associate professor,
Department of Clinical Medicine and Department of Molecular Biology and Genetics.
Address: Department of Molecular Biology and Genetics, C.F. Møllers Alle building 1130, Aarhus University, 8000 Aarhus C, Denmark.
Phone: +45 871 55479 (office); +45 871 54974 (lab); +45 4095 2448 (cell).
E-mail: LP@mb.au.dk

Positions

2016Associate Professor at Department of Molecular Biology and Genetics
2015 Associate Professor at Department of Molecular Biology and Genetics associated with Department of Clinical Medicine
2008-Associate Professor (permanent post) at Department of Clinical Medicine with working place at Department of Molecular Biology and Genetics
2007-2008Partial leave for family care
2002Associate Professor (permanent post) at Department of Clinical Medicine with working place at Department of Molecular Biology and Genetics
1999Associate Professor at Dept. of Molecular and Structural Biology (DMSB), Aarhus University, Denmark.
1996Post doctoral fellow at DMSB, Aarhus University, Denmark.
1994Research assistant at DMSB, Aarhus University, Denmark.
1993Post doctoral fellow at Lederle Laboratories, American Cyanamid Company, Pearl River, N.Y.
1988Research assistant at DMSB, Aarhus University, Denmark.
1988Jan. – Feb. Research assistant at Department of Molecular Virology (DMV), GSF, Munich, FRG.
1987Research fellow (European Communities Research and Development Programme) DMV, GSF, Munich, FRG.

Education and training

2016 Advanced course in Laboratory Animal Science - Experimental surgical techniques
2015 Basic course in Laboratory Animal Science
2011 Management course provided by Learn2Lead, 6 days.
1998 Course in pedagogics for surpervisors and post docs at Universities.
1996 Ph.D. (licentiatgraden) in Molecular Biology, Aarhus University.
1994 Cand. scient. degree evaluated as equivalent to an American Ph.D. degree.
1987 Cand. scient. in Biology, Aarhus University (9 months of thesis at Department of Molecular Virology (DMV), GSF, Munich, FRG).
1983, Bachelor degree in Chemistry, Aarhus University.

Research abroad

Cand. scient.-student (9 months) March - Dec. 1985, DMV, GSF, Munich, FRG.
Research fellow (9 months) June 1987- March 1988, DMV, GSF, Munich, FRG.
Guest scientist (1 month) Nov.- Dec. 1991, DMV, GSF, Munich, FRG.
Guest scientist (2 months) Oct.- Nov. 1992, DMV, GSF, Munich, FRG.
Post doc (15 months) July 1993 - Oct. 1994, Lederle Laboratories, New York, USA.

Fellowships and travel grants

Scholarship from Danish Cancer Society (1985, 12 months).
Fellowship from European Communities Research and Development Programme (1987, 6 months).
Travel fellowship from Federation of European Microbiological Societies (1992, 2 months).
Travel grant from Danish Research Academy (1993, 12 months).
Senior fellowship from the Danish Medical Research Council (1999 - 2002, 3 years).

Scientific summary

Area of research: Cellular inorganic phosphate homeostasis; type III inorganic phosphate transporters and their physiologic and pathologic roles including in neurobiology and vascular calcification; inorganic phosphate in normal and pathologic mineralization; vascular calcification; familial idiopathic basal ganglia calcification (FIBGC) (Fahr’s disease); causes of and effects of hyperphosphatemia; cardiovascular diseases; cancer; cell metabolism and aging; stem cells; osteblastic differentiation; retroviral infection; retroviral pathology; retroviral receptor functions; retroviral vector technology.

Scientific leadership: Research group leader from 1996. Leading independent research group from 2002.

Publications:
Publications:
Co-author of 35 original articles in international journals with peer-review, 1 invited book-chapter, 1 patent, and 1 popular science article in Danish.

5 most cited articles per February 2017:
Beer, C., D. S. Andersen, A. Rojek, and L. Pedersen. Caveolae-Dependent Endocytic Entry of Amphotropic Murine Leukemia Virus. J. Virol. 79, 10776-10787, 2005. (WOS: 56 citations).

Nielsen, L. B., F. S. Pedersen, and L. Pedersen. Expression of Type III Sodium-Dependent Phosphate Transporters/Retroviral Receptors mRNAs during Osteoblast Differentiation. Bone 28 (2), 160-166, 2001. (WOS: 51 citations).

Pedersen, L., S. V. Johann, M. van Zeijl, F. S. Pedersen, and B. O’Hara. Chimeras of Receptors for Gibbon Ape Leukemia Virus/Feline Leukemia Virus B and Amphotropic Murine Leukemia Virus Reveal Different Modes of Receptor Recognition by Retrovirus. J. Virol. 69, 2401-2405, 1995. (WOS: 49 citations).

Uckert, W, G. Willimsky, F. S. Pedersen, T. Blankenstein, and L. Pedersen. RNA Levels of Human Retrovirus Receptors Pit1and Pit2 Do not Correlate with Infectibility by Three Retroviral Vector Pseudotypes. Hum. Gene Ther. 9, 2619-2627, 1998. (WOS: 45 citations).

Uckert, W., C. Becker, M. Gladow, D. Klein, T. Kammertoens, L. Pedersen, and T. Blankenstein. Efficient Gene Transfer into Primary Human CD8+ T Lymphocytes by MuLV-10A1 Retrovirus Pseudotype. Hum. Gene Ther. 11, 1005-1014, 2000. (WOS: 33 citations).

International scientific congresses:
Accepted invited speaker/chairs at international scientific congresses: 5.
LP-laboratory participation in international scientific congresses with oral presentations: 19.
The LP-laboratory has in addition participated in numerous international scientific congresses with poster presentations.

Current international collaboration: M.D., PhD, João Ricardo Mendes de Oliveira, Federal University of Pernambuco, Recife, Brazil.

Membership of societies: The American Society for Bone and Mineral Research.

Research funding since 2002 (larger grants only and not including post doc’s and Ph.D.-student’s grants for own salaries)

Foundation/first year of donation period/%-share (if shared)/total amount.
The Danish Cancer Society/2002/500 000 kr.
The Lundbeck Foundation/2002/share 50%/ 2 475 000 kr.
The Novo Nordisk Foundation/2003 – 300 000 kr./2003 -300 000 kr./2004- 100 000 kr./2008 – 350 000 kr.
The Danish Council for Independent Research - Medical Sciences/2004/900 000 kr.
The Carlsberg Foundation/2005 – 447 275 kr/2006 – 454 537 kr.
The Danish Heart Association/2006/190 000 kr.
The Danish Council for Independent Research - Medical Sciences/2006/420 000 kr.
The Danish Council for Independent Research - Medical Sciences/2007/464 275 kr.
The Danish Council for Independent Research - Medical Sciences/2009/1 417 500 kr.

Teaching and supervision

Teaching activities from 1996 to present have mainly been at the courses:
Molecular Cell Biology (undergraduate course).
Gene therapy and Hematology (graduate course; responsible teacher).
Stem Cell Therapy (graduate course; responsible teacher).
The Cancermodule (graduate course).
Molecular Virology (graduate course), at University of Copenhagen.
Cell Biology in Health and Disease (graduate course; responsible teacher) (start 2011).
Cell Biology in Health and Disease –Seminars (graduate course) (start 2011).

Currently teaching at the courses:
Molecular Cell Biology (undergraduate course for students of Molecular Biology and Molecular Medicine).
Cell Biology in Health and Disease (graduate course; responsible teacher)
The Cancermodule (graduate course) for students of Molecular Medicine.

Supervision:
Main supervisor for graduated students: 16 cand. scients. and 9 Ph.D.’s.
Post doctoral training: 3 post docs.

Evaluation of others work

Member of the evaluation committees for full Professorships:
2010: Life, University of Copenhagen.
2004: Research Unit for Anatomy and Neurobiology, Department of Medical Biology, University of Southern Denmark.
2000: Department of Microbiology and Immunology at The University of Tennessee, Memphis, TN.

Ad hoc reviewer for: Cell reports, EMBO Reports, PLOS ONE, FEBS J., FEBS Letters, BioResearch Open Access, Human Gene Therapy, J. Virol., Virology, J. Gen. Virol., Retrovirology

Committee work

2001 - 2004: Member of the “Board of Department” at Department of Molecular Biology.
2004 - 2011: Member of the “Committee for Ph.D. Studies” at Department of Molecular Biology.

Patents

Schmidt, J., W. Gimbel, P. G. Strauss, M. Østergaard, L. Pedersen, F. S. Pedersen, and V. Erfle. RFB Retrovirus Genome. PCT application no.: WO 95/27063. Publication number EP 0755 448, publication date 12.10.95 (70 pp, 35 examples, and 7 figures) European patent application EP95 916604.2, 5.11.96 (German patent application DPA P44 11 718.3, 5.4.1994).