Leif Østergaard

Microstructural changes in the thalamus after mild traumatic brain injury: A longitudinal diffusion and mean kurtosis tensor MRI study

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Microstructural changes in the thalamus after mild traumatic brain injury : A longitudinal diffusion and mean kurtosis tensor MRI study. / Næss-Schmidt, Erhard Trillingsgaard; Blicher, Jakob Udby; Eskildsen, Simon Fristed; Tietze, Anna; Hansen, Brian; Stubbs, Peter William; Jespersen, Sune; Østergaard, Leif; Nielsen, Jørgen Feldbæk.

In: Brain Injury, Vol. 31, No. 2, 05.01.2017, p. 230-236.

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@article{08a964c77bca4546a82b5867ea0c3ddb,
title = "Microstructural changes in the thalamus after mild traumatic brain injury: A longitudinal diffusion and mean kurtosis tensor MRI study",
abstract = "PRIMARY OBJECTIVE: The primary aim of this study was to assess microstructural changes in the thalamus, hippocampus and corpus callosum with a fast mean kurtosis tensor (MKT) technique, in the acute and sub-acute phase after mTBI. It was hypothesized that MKT would differ between baseline and follow-up in patients. The secondary aim was to relate diffusion measures to symptoms of mTBI.RESEARCH DESIGN: A longitudinal case-control study.METHODS AND PROCEDURES: Twenty-seven patients with mTBI and 27 age- and gender-matched healthy controls were enrolled in the study. Patients were scanned within 2 weeks and 3 months after mTBI, while the controls were scanned once.MAIN OUTCOMES AND RESULTS: MKT decreased significantly (p = 0.02) from baseline to follow-up in the thalamus in patients. Compared to healthy subjects, thalamic MKT values were significantly larger in patients at baseline (p = 0.048). Secondary analysis revealed a significant decrease (p = 0.01) in fractional anisotropy in the splenium of corpus callosum from baseline to follow-up.CONCLUSIONS: The current study indicates microstructural changes in the thalamus and corpus callosum from within 14 days to 3 months after mTBI and suggests MKT as a potential biomarker after mTBI.",
author = "N{\ae}ss-Schmidt, {Erhard Trillingsgaard} and Blicher, {Jakob Udby} and Eskildsen, {Simon Fristed} and Anna Tietze and Brian Hansen and Stubbs, {Peter William} and Sune Jespersen and Leif {\O}stergaard and Nielsen, {J{\o}rgen Feldb{\ae}k}",
year = "2017",
month = jan,
day = "5",
doi = "10.1080/02699052.2016.1229034",
language = "English",
volume = "31",
pages = "230--236",
journal = "Brain Injury",
issn = "0269-9052",
publisher = "Taylor & Francis ",
number = "2",

}

RIS

TY - JOUR

T1 - Microstructural changes in the thalamus after mild traumatic brain injury

T2 - A longitudinal diffusion and mean kurtosis tensor MRI study

AU - Næss-Schmidt, Erhard Trillingsgaard

AU - Blicher, Jakob Udby

AU - Eskildsen, Simon Fristed

AU - Tietze, Anna

AU - Hansen, Brian

AU - Stubbs, Peter William

AU - Jespersen, Sune

AU - Østergaard, Leif

AU - Nielsen, Jørgen Feldbæk

PY - 2017/1/5

Y1 - 2017/1/5

N2 - PRIMARY OBJECTIVE: The primary aim of this study was to assess microstructural changes in the thalamus, hippocampus and corpus callosum with a fast mean kurtosis tensor (MKT) technique, in the acute and sub-acute phase after mTBI. It was hypothesized that MKT would differ between baseline and follow-up in patients. The secondary aim was to relate diffusion measures to symptoms of mTBI.RESEARCH DESIGN: A longitudinal case-control study.METHODS AND PROCEDURES: Twenty-seven patients with mTBI and 27 age- and gender-matched healthy controls were enrolled in the study. Patients were scanned within 2 weeks and 3 months after mTBI, while the controls were scanned once.MAIN OUTCOMES AND RESULTS: MKT decreased significantly (p = 0.02) from baseline to follow-up in the thalamus in patients. Compared to healthy subjects, thalamic MKT values were significantly larger in patients at baseline (p = 0.048). Secondary analysis revealed a significant decrease (p = 0.01) in fractional anisotropy in the splenium of corpus callosum from baseline to follow-up.CONCLUSIONS: The current study indicates microstructural changes in the thalamus and corpus callosum from within 14 days to 3 months after mTBI and suggests MKT as a potential biomarker after mTBI.

AB - PRIMARY OBJECTIVE: The primary aim of this study was to assess microstructural changes in the thalamus, hippocampus and corpus callosum with a fast mean kurtosis tensor (MKT) technique, in the acute and sub-acute phase after mTBI. It was hypothesized that MKT would differ between baseline and follow-up in patients. The secondary aim was to relate diffusion measures to symptoms of mTBI.RESEARCH DESIGN: A longitudinal case-control study.METHODS AND PROCEDURES: Twenty-seven patients with mTBI and 27 age- and gender-matched healthy controls were enrolled in the study. Patients were scanned within 2 weeks and 3 months after mTBI, while the controls were scanned once.MAIN OUTCOMES AND RESULTS: MKT decreased significantly (p = 0.02) from baseline to follow-up in the thalamus in patients. Compared to healthy subjects, thalamic MKT values were significantly larger in patients at baseline (p = 0.048). Secondary analysis revealed a significant decrease (p = 0.01) in fractional anisotropy in the splenium of corpus callosum from baseline to follow-up.CONCLUSIONS: The current study indicates microstructural changes in the thalamus and corpus callosum from within 14 days to 3 months after mTBI and suggests MKT as a potential biomarker after mTBI.

U2 - 10.1080/02699052.2016.1229034

DO - 10.1080/02699052.2016.1229034

M3 - Journal article

C2 - 28055267

VL - 31

SP - 230

EP - 236

JO - Brain Injury

JF - Brain Injury

SN - 0269-9052

IS - 2

ER -