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Leif Østergaard

Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease

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Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease. / Nielsen, Rune B; Egefjord, Lærke; Angleys, Hugo; Mouridsen, Kim; Gejl, Michael; Møller, Arne; Brock, Birgitte; Brændgaard, Hans; Gottrup, Hanne; Rungby, Jørgen; Eskildsen, Simon F; Østergaard, Leif.

In: Alzheimer's & Dementia, Vol. 13, No. 10, 10.2017, p. 1143-1153.

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Author

Nielsen, Rune B ; Egefjord, Lærke ; Angleys, Hugo ; Mouridsen, Kim ; Gejl, Michael ; Møller, Arne ; Brock, Birgitte ; Brændgaard, Hans ; Gottrup, Hanne ; Rungby, Jørgen ; Eskildsen, Simon F ; Østergaard, Leif. / Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease. In: Alzheimer's & Dementia. 2017 ; Vol. 13, No. 10. pp. 1143-1153.

Bibtex

@article{14adea9d00a243a98da41a60ba0a981c,
title = "Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease",
abstract = "INTRODUCTION: We examined whether cortical microvascular blood volume and hemodynamics in Alzheimer's disease (AD) are consistent with tissue hypoxia and whether they correlate with cognitive performance and the degree of cortical thinning.METHODS: Thirty-two AD patients underwent cognitive testing, structural magnetic resonance imaging (MRI), and perfusion MRI at baseline and after 6 months. We measured cortical thickness, microvascular cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), and capillary transit time heterogeneity (CTH) and estimated tissue oxygen tension (PtO2).RESULTS: At baseline, poor cognitive performance and regional cortical thinning correlated with lower CBF and CBV, with higher MTT and CTH and with low PtO2 across the cortex. Cognitive decline over time was associated with increasing whole brain relative transit time heterogeneity (RTH = CTH/MTT).DISCUSSION: Our results confirm the importance of microvascular pathology in AD. Deteriorating microvascular hemodynamics may cause hypoxia, which is known to precipitate amyloid retention.",
keywords = "Journal Article",
author = "Nielsen, {Rune B} and L{\ae}rke Egefjord and Hugo Angleys and Kim Mouridsen and Michael Gejl and Arne M{\o}ller and Birgitte Brock and Hans Br{\ae}ndgaard and Hanne Gottrup and J{\o}rgen Rungby and Eskildsen, {Simon F} and Leif {\O}stergaard",
note = "Copyright {\textcopyright} 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.",
year = "2017",
month = oct,
doi = "10.1016/j.jalz.2017.02.007",
language = "English",
volume = "13",
pages = "1143--1153",
journal = "Alzheimer's & Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease

AU - Nielsen, Rune B

AU - Egefjord, Lærke

AU - Angleys, Hugo

AU - Mouridsen, Kim

AU - Gejl, Michael

AU - Møller, Arne

AU - Brock, Birgitte

AU - Brændgaard, Hans

AU - Gottrup, Hanne

AU - Rungby, Jørgen

AU - Eskildsen, Simon F

AU - Østergaard, Leif

N1 - Copyright © 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

PY - 2017/10

Y1 - 2017/10

N2 - INTRODUCTION: We examined whether cortical microvascular blood volume and hemodynamics in Alzheimer's disease (AD) are consistent with tissue hypoxia and whether they correlate with cognitive performance and the degree of cortical thinning.METHODS: Thirty-two AD patients underwent cognitive testing, structural magnetic resonance imaging (MRI), and perfusion MRI at baseline and after 6 months. We measured cortical thickness, microvascular cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), and capillary transit time heterogeneity (CTH) and estimated tissue oxygen tension (PtO2).RESULTS: At baseline, poor cognitive performance and regional cortical thinning correlated with lower CBF and CBV, with higher MTT and CTH and with low PtO2 across the cortex. Cognitive decline over time was associated with increasing whole brain relative transit time heterogeneity (RTH = CTH/MTT).DISCUSSION: Our results confirm the importance of microvascular pathology in AD. Deteriorating microvascular hemodynamics may cause hypoxia, which is known to precipitate amyloid retention.

AB - INTRODUCTION: We examined whether cortical microvascular blood volume and hemodynamics in Alzheimer's disease (AD) are consistent with tissue hypoxia and whether they correlate with cognitive performance and the degree of cortical thinning.METHODS: Thirty-two AD patients underwent cognitive testing, structural magnetic resonance imaging (MRI), and perfusion MRI at baseline and after 6 months. We measured cortical thickness, microvascular cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), and capillary transit time heterogeneity (CTH) and estimated tissue oxygen tension (PtO2).RESULTS: At baseline, poor cognitive performance and regional cortical thinning correlated with lower CBF and CBV, with higher MTT and CTH and with low PtO2 across the cortex. Cognitive decline over time was associated with increasing whole brain relative transit time heterogeneity (RTH = CTH/MTT).DISCUSSION: Our results confirm the importance of microvascular pathology in AD. Deteriorating microvascular hemodynamics may cause hypoxia, which is known to precipitate amyloid retention.

KW - Journal Article

U2 - 10.1016/j.jalz.2017.02.007

DO - 10.1016/j.jalz.2017.02.007

M3 - Journal article

C2 - 28343848

VL - 13

SP - 1143

EP - 1153

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

SN - 1552-5260

IS - 10

ER -