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Laurits Skov

A high-coverage Neandertal genome from Vindija Cave in Croatia

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A high-coverage Neandertal genome from Vindija Cave in Croatia. / Prüfer, Kay; de Filippo, Cesare; Grote, Steffi et al.

In: Science, Vol. 358, No. 6363, 03.11.2017, p. 655-658.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Prüfer, K, de Filippo, C, Grote, S, Mafessoni, F, Korlević, P, Hajdinjak, M, Vernot, B, Skov, L, Hsieh, P, Peyrégne, S, Reher, D, Hopfe, C, Nagel, S, Maricic, T, Fu, Q, Theunert, C, Theunert, C, Rogers, R, Skoglund, P, Chintalapati, M, Dannemann, M, Nelson, BJ, Key, FM, Rudan, P, Kućan, Ž, Gušić, I, Golovanova, LV, Doronichev, VB, Patterson, N, Reich, D, Reich, D, Reich, D, Eichler, EE, Eichler, EE, Slatkin, M, Schierup, MH, Andrés, A, Kelso, J, Meyer, M & Pääbo, S 2017, 'A high-coverage Neandertal genome from Vindija Cave in Croatia', Science, vol. 358, no. 6363, pp. 655-658. https://doi.org/10.1126/science.aao1887

APA

Prüfer, K., de Filippo, C., Grote, S., Mafessoni, F., Korlević, P., Hajdinjak, M., Vernot, B., Skov, L., Hsieh, P., Peyrégne, S., Reher, D., Hopfe, C., Nagel, S., Maricic, T., Fu, Q., Theunert, C., Theunert, C., Rogers, R., Skoglund, P., ... Pääbo, S. (2017). A high-coverage Neandertal genome from Vindija Cave in Croatia. Science, 358(6363), 655-658. https://doi.org/10.1126/science.aao1887

CBE

Prüfer K, de Filippo C, Grote S, Mafessoni F, Korlević P, Hajdinjak M, Vernot B, Skov L, Hsieh P, Peyrégne S, et al. 2017. A high-coverage Neandertal genome from Vindija Cave in Croatia. Science. 358(6363):655-658. https://doi.org/10.1126/science.aao1887

MLA

Vancouver

Prüfer K, de Filippo C, Grote S, Mafessoni F, Korlević P, Hajdinjak M et al. A high-coverage Neandertal genome from Vindija Cave in Croatia. Science. 2017 Nov 3;358(6363):655-658. https://doi.org/10.1126/science.aao1887

Author

Prüfer, Kay ; de Filippo, Cesare ; Grote, Steffi et al. / A high-coverage Neandertal genome from Vindija Cave in Croatia. In: Science. 2017 ; Vol. 358, No. 6363. pp. 655-658.

Bibtex

@article{30acad827c8b43ed98bbde771ff7b4cc,
title = "A high-coverage Neandertal genome from Vindija Cave in Croatia",
abstract = "{\textcopyright} 2017 American Association for the Advancement of Science. To date the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~50 thousand years ago from Vindija Cave, Croatia to ~30-fold genomic coverage. She carried 1.6 differences per ten thousand base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10-20% more Neandertal DNA to be identified in present-day humans, including variants involved in LDL cholesterol levels, schizophrenia and other diseases.",
author = "Kay Pr{\"u}fer and {de Filippo}, Cesare and Steffi Grote and Fabrizio Mafessoni and Petra Korlevi{\'c} and Mateja Hajdinjak and Benjamin Vernot and Laurits Skov and Pinghsun Hsieh and St{\'e}phane Peyr{\'e}gne and David Reher and Charlotte Hopfe and Sarah Nagel and Tomislav Maricic and Qiaomei Fu and Christoph Theunert and Christoph Theunert and Rebekah Rogers and Pontus Skoglund and Manjusha Chintalapati and Michael Dannemann and Nelson, {Bradley J.} and Key, {Felix M.} and Pavao Rudan and {\v Z}eljko Ku{\'c}an and Ivan Gu{\v s}i{\'c} and Golovanova, {Liubov V.} and Doronichev, {Vladimir B.} and Nick Patterson and David Reich and David Reich and David Reich and Eichler, {Evan E.} and Eichler, {Evan E.} and Montgomery Slatkin and Schierup, {Mikkel H.} and Aida Andr{\'e}s and Janet Kelso and Matthias Meyer and Svante P{\"a}{\"a}bo",
year = "2017",
month = nov,
day = "3",
doi = "10.1126/science.aao1887",
language = "English",
volume = "358",
pages = "655--658",
journal = "Science",
issn = "0036-8075",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "6363",

}

RIS

TY - JOUR

T1 - A high-coverage Neandertal genome from Vindija Cave in Croatia

AU - Prüfer, Kay

AU - de Filippo, Cesare

AU - Grote, Steffi

AU - Mafessoni, Fabrizio

AU - Korlević, Petra

AU - Hajdinjak, Mateja

AU - Vernot, Benjamin

AU - Skov, Laurits

AU - Hsieh, Pinghsun

AU - Peyrégne, Stéphane

AU - Reher, David

AU - Hopfe, Charlotte

AU - Nagel, Sarah

AU - Maricic, Tomislav

AU - Fu, Qiaomei

AU - Theunert, Christoph

AU - Theunert, Christoph

AU - Rogers, Rebekah

AU - Skoglund, Pontus

AU - Chintalapati, Manjusha

AU - Dannemann, Michael

AU - Nelson, Bradley J.

AU - Key, Felix M.

AU - Rudan, Pavao

AU - Kućan, Željko

AU - Gušić, Ivan

AU - Golovanova, Liubov V.

AU - Doronichev, Vladimir B.

AU - Patterson, Nick

AU - Reich, David

AU - Reich, David

AU - Reich, David

AU - Eichler, Evan E.

AU - Eichler, Evan E.

AU - Slatkin, Montgomery

AU - Schierup, Mikkel H.

AU - Andrés, Aida

AU - Kelso, Janet

AU - Meyer, Matthias

AU - Pääbo, Svante

PY - 2017/11/3

Y1 - 2017/11/3

N2 - © 2017 American Association for the Advancement of Science. To date the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~50 thousand years ago from Vindija Cave, Croatia to ~30-fold genomic coverage. She carried 1.6 differences per ten thousand base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10-20% more Neandertal DNA to be identified in present-day humans, including variants involved in LDL cholesterol levels, schizophrenia and other diseases.

AB - © 2017 American Association for the Advancement of Science. To date the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~50 thousand years ago from Vindija Cave, Croatia to ~30-fold genomic coverage. She carried 1.6 differences per ten thousand base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10-20% more Neandertal DNA to be identified in present-day humans, including variants involved in LDL cholesterol levels, schizophrenia and other diseases.

U2 - 10.1126/science.aao1887

DO - 10.1126/science.aao1887

M3 - Journal article

C2 - 28982794

AN - SCOPUS:85030853901

VL - 358

SP - 655

EP - 658

JO - Science

JF - Science

SN - 0036-8075

IS - 6363

ER -