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Laurits Emil Taul Madsen

A Head-to-Head Comparison of an Isometric and a Concentric Fatigability Protocol and the Association With Fatigue and Walking in Persons With Multiple Sclerosis

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A Head-to-Head Comparison of an Isometric and a Concentric Fatigability Protocol and the Association With Fatigue and Walking in Persons With Multiple Sclerosis. / Taul-Madsen, Laurits; Dalgas, Ulrik; Kjølhede, Tue et al.
In: Neurorehabilitation and Neural Repair, Vol. 34, No. 6, 06.2020, p. 523-532.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Taul-Madsen, L, Dalgas, U, Kjølhede, T, Hvid, LG, Petersen, T & Riemenschneider, M 2020, 'A Head-to-Head Comparison of an Isometric and a Concentric Fatigability Protocol and the Association With Fatigue and Walking in Persons With Multiple Sclerosis', Neurorehabilitation and Neural Repair, vol. 34, no. 6, pp. 523-532. https://doi.org/10.1177/1545968320920250

APA

Taul-Madsen, L., Dalgas, U., Kjølhede, T., Hvid, L. G., Petersen, T., & Riemenschneider, M. (2020). A Head-to-Head Comparison of an Isometric and a Concentric Fatigability Protocol and the Association With Fatigue and Walking in Persons With Multiple Sclerosis. Neurorehabilitation and Neural Repair, 34(6), 523-532. Advance online publication. https://doi.org/10.1177/1545968320920250

CBE

Taul-Madsen L, Dalgas U, Kjølhede T, Hvid LG, Petersen T, Riemenschneider M. 2020. A Head-to-Head Comparison of an Isometric and a Concentric Fatigability Protocol and the Association With Fatigue and Walking in Persons With Multiple Sclerosis. Neurorehabilitation and Neural Repair. 34(6):523-532. https://doi.org/10.1177/1545968320920250

MLA

Taul-Madsen, Laurits et al. "A Head-to-Head Comparison of an Isometric and a Concentric Fatigability Protocol and the Association With Fatigue and Walking in Persons With Multiple Sclerosis". Neurorehabilitation and Neural Repair. 2020, 34(6). 523-532. https://doi.org/10.1177/1545968320920250

Vancouver

Taul-Madsen L, Dalgas U, Kjølhede T, Hvid LG, Petersen T, Riemenschneider M. A Head-to-Head Comparison of an Isometric and a Concentric Fatigability Protocol and the Association With Fatigue and Walking in Persons With Multiple Sclerosis. Neurorehabilitation and Neural Repair. 2020 Jun;34(6):523-532. Epub 2020. doi: 10.1177/1545968320920250

Author

Taul-Madsen, Laurits ; Dalgas, Ulrik ; Kjølhede, Tue et al. / A Head-to-Head Comparison of an Isometric and a Concentric Fatigability Protocol and the Association With Fatigue and Walking in Persons With Multiple Sclerosis. In: Neurorehabilitation and Neural Repair. 2020 ; Vol. 34, No. 6. pp. 523-532.

Bibtex

@article{31a402ab7757443b808362f50b0d14e4,
title = "A Head-to-Head Comparison of an Isometric and a Concentric Fatigability Protocol and the Association With Fatigue and Walking in Persons With Multiple Sclerosis",
abstract = "Background. Fatigue is one of the most frequent symptoms in persons with multiple sclerosis (MS). Distinction is made between subjective perceptions of fatigue and objective measures of fatigability. Fatigability can be measured by different protocols. Yet no studies have compared isometric and concentric contraction protocols of the lower extremities head-to-head. Therefore, the purpose of the present study was to (1) compare 2 such protocols head-to-head and (2) to investigate the association between fatigability evoked by the 2 protocols and measures of fatigue and walking. Methods. A total of 45 patients with MS had their walking capacity measured objectively by the 6-minute walk test (6MWT) and subjectively by the 12-item Multiple Sclerosis Walking Scale (MSWS-12). Fatigue was measured by the Modified Fatigue Impact Scale (MFIS) and fatigability by 2 knee extension protocols: sustained isometric and concentric. Results. The sustained isometric protocol induced a higher degree of fatigability than the concentric protocol (P <.01). Regression analyses revealed that sustained isometric fatigability was not associated with either measures of fatigue or walking (all r2 = 0.00; P =.85-.99), whereas the concentric protocol was significantly associated with fatigue (r2 = 0.20; P <.01), 6MWT (r2 = 0.09; P <.05), and MSWS-12 (r2 = 0.16; P <.01). Furthermore, after adjusting for maximal strength and sex, concentric fatigability remained a strong and significant predictor of fatigue (β = 0.49) and walking (6MWT: β = −0.26; MSWS: β = 0.37). Conclusion. This study provides the first evidence that a lower-extremity concentric fatigability protocol provides superior reflection of both fatigue and walking when compared with a sustained isometric protocol. We suggest that concentric protocols should be the focus of future studies investigating fatigability.",
keywords = "fatigability, fatigue, multiple sclerosis, walking, MOTOR FATIGABILITY, ACTIVATION, ENDURANCE, PERFORMANCE, ADAPTATIONS, BLOOD-FLOW, CONTRACTIONS, PERCEIVED FATIGUE, MUSCLE STRENGTH, REHABILITATION",
author = "Laurits Taul-Madsen and Ulrik Dalgas and Tue Kj{\o}lhede and Hvid, {Lars G.} and Thor Petersen and Morten Riemenschneider",
year = "2020",
month = jun,
doi = "10.1177/1545968320920250",
language = "English",
volume = "34",
pages = "523--532",
journal = "Neurorehabilitation and Neural Repair",
issn = "1545-9683",
publisher = "Sage Publications, Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - A Head-to-Head Comparison of an Isometric and a Concentric Fatigability Protocol and the Association With Fatigue and Walking in Persons With Multiple Sclerosis

AU - Taul-Madsen, Laurits

AU - Dalgas, Ulrik

AU - Kjølhede, Tue

AU - Hvid, Lars G.

AU - Petersen, Thor

AU - Riemenschneider, Morten

PY - 2020/6

Y1 - 2020/6

N2 - Background. Fatigue is one of the most frequent symptoms in persons with multiple sclerosis (MS). Distinction is made between subjective perceptions of fatigue and objective measures of fatigability. Fatigability can be measured by different protocols. Yet no studies have compared isometric and concentric contraction protocols of the lower extremities head-to-head. Therefore, the purpose of the present study was to (1) compare 2 such protocols head-to-head and (2) to investigate the association between fatigability evoked by the 2 protocols and measures of fatigue and walking. Methods. A total of 45 patients with MS had their walking capacity measured objectively by the 6-minute walk test (6MWT) and subjectively by the 12-item Multiple Sclerosis Walking Scale (MSWS-12). Fatigue was measured by the Modified Fatigue Impact Scale (MFIS) and fatigability by 2 knee extension protocols: sustained isometric and concentric. Results. The sustained isometric protocol induced a higher degree of fatigability than the concentric protocol (P <.01). Regression analyses revealed that sustained isometric fatigability was not associated with either measures of fatigue or walking (all r2 = 0.00; P =.85-.99), whereas the concentric protocol was significantly associated with fatigue (r2 = 0.20; P <.01), 6MWT (r2 = 0.09; P <.05), and MSWS-12 (r2 = 0.16; P <.01). Furthermore, after adjusting for maximal strength and sex, concentric fatigability remained a strong and significant predictor of fatigue (β = 0.49) and walking (6MWT: β = −0.26; MSWS: β = 0.37). Conclusion. This study provides the first evidence that a lower-extremity concentric fatigability protocol provides superior reflection of both fatigue and walking when compared with a sustained isometric protocol. We suggest that concentric protocols should be the focus of future studies investigating fatigability.

AB - Background. Fatigue is one of the most frequent symptoms in persons with multiple sclerosis (MS). Distinction is made between subjective perceptions of fatigue and objective measures of fatigability. Fatigability can be measured by different protocols. Yet no studies have compared isometric and concentric contraction protocols of the lower extremities head-to-head. Therefore, the purpose of the present study was to (1) compare 2 such protocols head-to-head and (2) to investigate the association between fatigability evoked by the 2 protocols and measures of fatigue and walking. Methods. A total of 45 patients with MS had their walking capacity measured objectively by the 6-minute walk test (6MWT) and subjectively by the 12-item Multiple Sclerosis Walking Scale (MSWS-12). Fatigue was measured by the Modified Fatigue Impact Scale (MFIS) and fatigability by 2 knee extension protocols: sustained isometric and concentric. Results. The sustained isometric protocol induced a higher degree of fatigability than the concentric protocol (P <.01). Regression analyses revealed that sustained isometric fatigability was not associated with either measures of fatigue or walking (all r2 = 0.00; P =.85-.99), whereas the concentric protocol was significantly associated with fatigue (r2 = 0.20; P <.01), 6MWT (r2 = 0.09; P <.05), and MSWS-12 (r2 = 0.16; P <.01). Furthermore, after adjusting for maximal strength and sex, concentric fatigability remained a strong and significant predictor of fatigue (β = 0.49) and walking (6MWT: β = −0.26; MSWS: β = 0.37). Conclusion. This study provides the first evidence that a lower-extremity concentric fatigability protocol provides superior reflection of both fatigue and walking when compared with a sustained isometric protocol. We suggest that concentric protocols should be the focus of future studies investigating fatigability.

KW - fatigability

KW - fatigue

KW - multiple sclerosis

KW - walking

KW - MOTOR FATIGABILITY

KW - ACTIVATION

KW - ENDURANCE

KW - PERFORMANCE

KW - ADAPTATIONS

KW - BLOOD-FLOW

KW - CONTRACTIONS

KW - PERCEIVED FATIGUE

KW - MUSCLE STRENGTH

KW - REHABILITATION

UR - http://www.scopus.com/inward/record.url?scp=85084844801&partnerID=8YFLogxK

U2 - 10.1177/1545968320920250

DO - 10.1177/1545968320920250

M3 - Journal article

C2 - 32396032

AN - SCOPUS:85084844801

VL - 34

SP - 523

EP - 532

JO - Neurorehabilitation and Neural Repair

JF - Neurorehabilitation and Neural Repair

SN - 1545-9683

IS - 6

ER -