A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma. / Das Mahapatra, Kunal; Pasquali, Lorenzo; Søndergaard, Jonas Nørskov; Lapins, Jan; Nemeth, István Balazs; Baltás, Eszter; Kemény, Lajos; Homey, Bernhard; Moldovan, Liviu Ionut; Kjems, Jørgen; Kutter, Claudia; Sonkoly, Enikö; Kristensen, Lasse Sommer; Pivarcsi, Andor.
In: Scientific Reports, Vol. 10, 3637, 12.2020.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome. / Moldovan, Liviu-Ionut; Hansen, Thomas Birkballe; Venø, Morten Trillingsgaard; Okholm, Trine Line Hauge; Andersen, Thomas Levin; Hager, Henrik; Iversen, Lars; Kjems, Jørgen; Johansen, Claus; Kristensen, Lasse Sommer.
In: BMC Medical Genomics, Vol. 12, No. 1, 174, 27.11.2019.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Identification of an IRF3 variant and defective antiviral interferon responses in a patient with severe influenza. / Thomsen, Michelle M; Jørgensen, Sofie E; Storgaard, Merete; Kristensen, Lasse S; Gjedsted, Jakob; Christiansen, Mette; Gad, Hans Henrik; Hartmann, Rune; Mogensen, Trine H.
In: European Journal of Immunology, Vol. 49, No. 11, 11.2019, p. 2111-2114.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate › Research › peer-review
The biogenesis, biology and characterization of circular RNAs. / Kristensen, Lasse Sommer; Schertz Andersen, Maria; Stagsted, Lotte Victoria Winther; Ebbesen, Karoline; Hansen, Thomas Birkballe; Kjems, Jørgen.
In: Nature Reviews. Genetics, Vol. 20, No. 11, 11.2019, p. 675-691.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Erratum to : Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations (Scientific Reports, (2017), 7, 1, (6774), 10.1038/s41598-017-07057-3). / Nielsen, Helene Myrtue; Andersen, Christen Lykkegaard; Westman, Maj; Kristensen, Lasse Sommer; Asmar, Fazila; Kruse, Torben Arvid; Thomassen, Mads; Larsen, Thomas Stauffer; Skov, Vibe; Hansen, Lise Lotte; Bjerrum, Ole Weis; Hasselbalch, Hans Carl; Punj, Vasu; Grønbæk, Kirsten.
In: Scientific Reports, Vol. 8, No. 1, 17311, 01.12.2018.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate › Research › peer-review
Long non-coding RNAs guide the fine-tuning of gene regulation in B-cell development and malignancy. / Dahl, Mette; Kristensen, Lasse Sommer; Grønbæk, Kirsten.
In: International Journal of Molecular Sciences, Vol. 19, No. 9, 2475, 01.09.2018.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
DNA methylation levels of the ELMO gene promoter CpG islands in human glioblastomas. / Michaelsen, Signe Regner; Aslan, Derya; Urup, Thomas; Poulsen, Hans Skovgaard; Grønbæk, Kirsten; Broholm, Helle; Kristensen, Lasse Sommer.
In: International Journal of Molecular Sciences, Vol. 19, No. 3, 679, 01.03.2018.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Circular RNAs in cancer : opportunities and challenges in the field. / Kristensen, L S; Hansen, T B; Venø, M T; Kjems, J.
In: Oncogene, Vol. 37, 01.02.2018, p. 555–565.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation. / Kristensen, Lasse Sommer; Okholm, Trine Line Hauge; Venø, Morten Trillingsgaard; Kjems, Jørgen.
In: RNA Biology, Vol. 15, No. 2, 2018, p. 1-12.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon-independent manner. / Dimopoulos, Konstantinos; Søgaard Helbo, Alexandra; Fibiger Munch-Petersen, Helga; Sjö, Lene; Christensen, Jesper; Sommer Kristensen, Lasse; Asmar, Fazila; Hermansen, Niels Emil Ulrich; O'Connel, Casey; Gimsing, Peter; Liang, Gangning; Grønbaek, Kirsten.
In: Molecular Oncology, Vol. 12, No. 2, 2018.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies. / Dahl, Mette; Daugaard, Iben; Andersen, Maria Schertz; Hansen, Thomas Birkballe; Grønbæk, Kirsten; Kjems, Jørgen; Kristensen, Lasse Sommer.
In: Laboratory Investigation, Vol. 98, 2018, p. 1657–1669.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Global hypomethylation is an independent prognostic factor in diffuse large B cell lymphoma. / Wedge, Eileen; Hansen, Jakob Werner; Garde, Christian; Asmar, Fazila; Tholstrup, Dorte; Kristensen, Søren Sommer; Munch-Petersen, Helga D.; Ralfkiaer, Elisabeth; Brown, Peter; Grønbæk, Kirsten; Kristensen, Lasse Sommer.
In: American Journal of Hematology, Vol. 92, No. 7, 01.07.2017, p. 689-694.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Mutations in idiopathic cytopenia of undetermined significance assist diagnostics and correlate to dysplastic changes. / Hansen, Jakob Werner; Westman, Maj Karoline; Sjö, Lene Dissing; Saft, Leonie; Kristensen, Lasse Sommer; Ørskov, Andreas Due; Treppendahl, Marianne; Andersen, Mette Klarskov; Grønbaek, Kirsten.
In: American Journal of Hematology, Vol. 91, No. 12, 12.2016, p. 1234-1238.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Identification and validation of candidate epigenetic biomarkers in lung adenocarcinoma. / Daugaard, Iben; Dominguez, Diana; Kjeldsen, Tina E; Kristensen, Lasse S; Hager, Henrik; Wojdacz, Tomasz K; Hansen, Lise Lotte.
In: Scientific Reports, Vol. 6, 35807, 26.10.2016.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations. / Aslan, Derya; Garde, Christian; Nygaard, Mette Katrine; Helbo, Alexandra Søgaard; Dimopoulos, Konstantinos; Hansen, Jacob Werner; Severinsen, Marianne Tang; Treppendahl, Marianne Bach; Sjø, Lene Dissing; Grønbæk, Kirsten; Kristensen, Lasse Sommer.
In: OncoTarget, Vol. 7, No. 9, 01.03.2016, p. 9951-63.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Assessment of Quantitative and Allelic MGMT Methylation Patterns as a Prognostic Marker in Glioblastoma. / Kristensen, Lasse S; Michaelsen, Signe R; Dyrbye, Henrik; Aslan, Derya; Grunnet, Kirsten; Christensen, Ib J; Poulsen, Hans S; Grønbæk, Kirsten; Broholm, Helle.
In: Journal of Neuropathology and Experimental Neurology, Vol. 75, No. 3, 03.2016, p. 246-55.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy. / Munch-Petersen, Helga D; Asmar, Fazila; Dimopoulos, Konstantinos; Areškevičiūtė, Aušrinė; Brown, Peter; Girkov, Mia Seremet; Pedersen, Anja; Sjö, Lene D; Heegaard, Steffen; Broholm, Helle; Kristensen, Lasse S; Ralfkiaer, Elisabeth; Grønbæk, Kirsten.
In: Acta Neuropathologica Communications, Vol. 4, 2016, p. 40.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Whole-exome sequencing and genome-wide methylation analyses identify novel disease associated mutations and methylation patterns in idiopathic hypereosinophilic syndrome. / Andersen, Christen Lykkegaard; Nielsen, Helene Myrtue; Kristensen, Lasse Sommer; Søgaard, Alexandra; Vikeså, Jonas; Jønson, Lars; Nielsen, Finn Cilius; Hasselbalch, Hans; Bjerrum, Ole Weis; Punj, Vasu; Grønbæk, Kirsten.
In: OncoTarget, Vol. 6, No. 38, 01.12.2015, p. 40588-97.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Allele-Specific DNA Methylation Detection by Pyrosequencing®. / Kristensen, Lasse Sommer; Johansen, Jens Vilstrup; Grønbæk, Kirsten.
In: Methods in molecular biology (Clifton, N.J.), Vol. 1315, 2015, p. 271-89.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Hypermethylation of the VTRNA1-3 Promoter is Associated with Poor Outcome in Lower Risk Myelodysplastic Syndrome Patients. / Helbo, Alexandra Søgaard; Treppendahl, Marianne; Aslan, Derya; Dimopoulos, Konstantinos; Nandrup-Bus, Cecilie; Holm, Mette Skov; Andersen, Mette Klarskov; Liang, Gangning; Kristensen, Lasse Sommer; Grønbæk, Kirsten.
In: Genes, Vol. 6, No. 4, 2015, p. 977-90.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Hypermethylation of DAPK1 is an independent prognostic factor predicting survival in diffuse large B-cell lymphoma. / Kristensen, Lasse Sommer; Asmar, Fazila; Dimopoulos, Konstantinos; Nygaard, Mette Kathrine; Aslan, Derya; Hansen, Jakob Werner; Ralfkiaer, Elisabeth; Grønbæk, Kirsten.
In: OncoTarget, Vol. 5, No. 20, 30.10.2014, p. 9798-810.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Genotyping common FSHR polymorphisms based on competitive amplification of differentially melting amplicons (CADMA). / Borgbo, Tanni; Sommer Kristensen, Lasse; Lindgren, Ida; Yding Andersen, Claus; Hansen, Lise Lotte.
In: Journal of Assisted Reproduction and Genetics, 21.09.2014.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Predicting response to epigenetic therapy. / Treppendahl, Marianne B; Kristensen, Lasse S; Grønbæk, Kirsten.
In: Journal of Clinical Investigation, Vol. 124, No. 1, 01.2014, p. 47-55.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
ELMO3: a direct driver of cancer metastasis? / Kristensen, Lasse Sommer; Søes, Signe; Hansen, Lise Lotte.
In: Cell Cycle, Vol. 13, No. 16, 2014, p. 2483-4.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Hypomethylation and increased expression of the putative oncogene ELMO3 are associated with lung cancer development and metastases formation. / Søes, Signe; Daugaard, Iben Lyster; Sørensen, Brita Singers; Carus, Andreas; Mattheisen, Manuel; Alsner, Jan; Overgaard, Jens; Hager, Henrik; Hansen, Lise Lotte; Kristensen, Lasse Sommer.
In: Oncoscience, Vol. 1, No. 5, 2014, p. 367-74.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
A role for immunohistochemical detection of BRAF V600E prior to BRAF-inhibitor treatment of malignant melanoma? / Lade-Keller, Johanne; Kristensen, Lasse Sommer; Riber-Hansen, Rikke; Guldberg, Per; Hansen, Lise Lotte; Steiniche, Torben; Hager, Henrik.
In: Journal of Clinical Pathology, Vol. 66, No. 8, 08.2013, p. 723-5.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Identification of accurate reference genes for RT-qPCR analysis of formalin-fixed paraffin-embedded tissue from primary Non-Small Cell Lung Cancers and brain and lymph node metastases. / Søes, Signe; Sørensen, Brita Singers; Alsner, Jan; Overgaard, Jens; Hager, Henrik; Hansen, Lise Lotte; Kristensen, Lasse Sommer.
In: Lung Cancer, Vol. 81, No. 2, 08.2013, p. 180-186.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Author's reply. / Kristensen, Lasse S; Hansen, Lise Lotte; Lade-Keller, Johanne; Riber-Hansen, Rikke; Steiniche, Torben; Hager, Henrik; Guldberg, Per.
In: The Journal of molecular diagnostics : JMD, Vol. 15, No. 4, 07.2013, p. 536-7.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate › Research
The challenges of comparing a clinically validated test to other methods. / Palma, John F; Shieh, Felice; Kristensen, Lasse Sommer; Hansen, Lise Lotte; Lade-Keller, Johanne; Riber-Hansen, Rikke; Steiniche, Torben; Hager, Henrik; Guldberg, Per.
In: Journal of Molecular Diagnostics, Vol. 15, No. 4, 07.2013, p. 535-537.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Analysis of epigenetic modifications of DNA in human cells. / Kristensen, Lasse Sommer; Treppendahl, Marianne Bach; Grønbæk, Kirsten.
In: Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.], Vol. Chapter 20, 04.2013, p. Unit20.2.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Evaluation of BRAF mutation testing methodologies in formalin-fixed, paraffin-embedded cutaneous melanomas. / Lade-Keller, Johanne; Rømer, Kirsten M; Guldberg, Per; Riber-Hansen, Rikke; Hansen, Lise Lotte; Steiniche, Torben; Hager, Henrik; Kristensen, Lasse S.
In: The Journal of molecular diagnostics : JMD, Vol. 15, No. 1, 01.2013, p. 70-80.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Investigation of MGMT and DAPK1 methylation patterns in diffuse large B-cell lymphoma using allelic MSP-pyrosequencing. / Kristensen, Lasse Sommer; Treppendahl, Marianne Bach; Asmar, Fazila; Girkov, Mia Seremet; Nielsen, Helene Myrtue; Kjeldsen, Tina Ellegaard; Ralfkiaer, Elisabeth; Hansen, Lise Lotte; Grønbæk, Kirsten.
In: Scientific Reports, Vol. 3, 2013, p. 2789.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Competitive amplification of differentially melting amplicons (CADMA) enables sensitive and direct detection of all mutation types by high-resolution melting analysis. / Kristensen, Lasse Sommer; Andersen, Gitte B; Hager, Henrik; Hansen, Lise Lotte.
In: Human Mutation, Vol. 33, No. 1, 2012, p. 264-71.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Competitive amplification of differentially melting amplicons (CADMA) improves KRAS hotspot mutation testing in colorectal cancer. / Kristensen, Lasse Sommer; Kjeldsen, Tina Ellegaard; Hager, Henrik; Hansen, Lise Lotte.
In: B M C Cancer, Vol. 12, 2012, p. 548.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
New drugs in melanoma provides new challenges for the pathologist. / Lade-Keller, Johanne; Kristensen, Lasse Sommer; Rømer, Kirsten; Guldberg, Per; Hager, Henrik; Riber-Hansen, Rikke; Hansen, Lise Lotte; Steiniche, Torben.
2012. Poster session presented at DPAS Årsmøde 2012, københavn, Denmark.Research output: Contribution to conference › Poster › Research
Sensitive Detection of DNA Methylation and Point Mutations in Cancer (epi) Genomes: Application to Personalized Medicine. / Kristensen, Lasse Sommer.
Aarhus Universitet, 2012.Research output: Book/anthology/dissertation/report › Ph.D. thesis › Research
Increased sensitivity of KRAS mutation detection by high-resolution melting analysis of COLD-PCR products. / Kristensen, Lasse S; Daugaard, Iben Lyster; Christensen, Mariann; Hamilton-Dutoit, Stephen; Hager, Henrik; Hansen, Lise Lotte.
In: Human Mutation, Vol. 31, No. 12, 2010, p. 1366-73.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Limitations and advantages of MS-HRM and bisulfite sequencing for single locus methylation studies. / Wojdacz, Tomasz K; Møller, Tine Hørning; Thestrup, Britta Boserup; Kristensen, Lasse Sommer; Hansen, Lise Lotte.
In: Expert Review of Molecular Diagnostics, Vol. 10, No. 5, 2010, p. 575-580.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Methylation of MGMT in malignant pleural mesothelioma occurs in a subset of patients and is associated with the T allele of the rs16906252 MGMT promoter SNP. / Kristensen, Lasse Sommer; Nielsen, Helene Myrtue; Hager, Henrik; Hansen, Lise Lotte.
In: Lung Cancer, 2010.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Epigenetics and cancer treatment. / Kristensen, Lasse Sommer; Myrtue Nielsen, Helene; Hansen, Lise Lotte.
In: European Journal of Pharmacology, Vol. 625, No. 1 - 3, 2009, p. 131 - 142.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
PCR-based methods for detecting single-locus DNA methylation biomarkers in cancer diagnostics, prognostics, and response to treatment. / Kristensen, Lasse Sommer; Hansen, Lise Lotte.
In: Clinical Chemistry, Vol. 55, No. 8, 2009, p. 1471-83.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Quality assessment of DNA derived from up to 30 years old formalin fixed paraffin embedded (FFPE) tissue for PCR-based methylation analysis using SMART-MSP and MS-HRM. / Kristensen, Lasse Sommer; Wojdacz, Tomasz K; Thestrup, Britta Boserup; Wiuf, Carsten Henrik; Hager, Henrik; Hansen, Lise Lotte.
In: B M C Cancer, Vol. 9, No. 453, 2009, p. 453.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
DNA methylation, epimutations and cancer predisposition. / Dobrovic, Alexander; Kristensen, Lasse S.
In: International Journal of Biochemistry & Cell Biology, Vol. 41, No. 1, 2008, p. 34-9.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Direct genotyping of single nucleotide polymorphisms in methyl metabolism genes using probe-free high-resolution melting analysis. / Kristensen, Lasse S; Dobrovic, Alexander.
In: Cancer Epidemiology, Biomarkers & Prevention, Vol. 17, No. 5, 2008, p. 1240-7.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection. / Kristensen, Lasse S; Mikeska, Thomas; Krypuy, Michael; Dobrovic, Alexander.
In: Nucleic Acids Research, Vol. 36, No. 7, 2008, p. e42.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review