Lars Toft Nielsen

Toksisk shock-syndrom

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Toxic shock syndrome is a rare, life-threatening disease caused by Staphylococcus aureus or Streptococcus pyogenes. These bacteria are able to produce superantigens, which bypass normal antigen presentation and cause a clonal T-cell expansion and uncontrolled release of pro-inflammatory mediators, which results in severe multiple organ failure. Despite high morbidity and mortality, the disease is underdiagnosed. In order to reduce morbidity and mortality early diagnosis and treatment with a combination of beta-lactam antibiotics, clindamycin and intravenous immunoglobulin is essential, which is underlined in this review.

Translated title of the contributionToxic shock syndrome
Original languageDanish
Article numberV11190673
JournalUgeskift for Læger
Volume182
Issue20
Number of pages9
ISSN0041-5782
Publication statusPublished - May 2020

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