Toxic shock syndrome is a rare disease caused by Gram-positive Staphylococcus aureus or Streptococcus pyogenes. These bacteria are able to produce a variety of exotoxins, including superantigens, which causes a cytokine storm and induces a shock condition. This is a case report of S. aureus toxic shock syndrome originating from a split skin transplant in a 75-year-old man, who met all clinical and laboratory criteria including development of rash, conjunctival hyper-aemia and desquamation of the skin. After treatment with antibiotics, immunoglobulins and supportive treatment, the disease dissolved.