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Lars Poulsen Tolbod

Optical detection of singlet oxygen from single cells

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Optical detection of singlet oxygen from single cells. / Snyder, John; Skovsen, Esben; Lambert, John D. C.; Poulsen, Lars; Ogilby, Peter Remsen.

In: Physical Chemistry Chemical Physics, Vol. 8, 2006, p. 4280-4293.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Snyder, J, Skovsen, E, Lambert, JDC, Poulsen, L & Ogilby, PR 2006, 'Optical detection of singlet oxygen from single cells', Physical Chemistry Chemical Physics, vol. 8, pp. 4280-4293.

APA

Snyder, J., Skovsen, E., Lambert, J. D. C., Poulsen, L., & Ogilby, P. R. (2006). Optical detection of singlet oxygen from single cells. Physical Chemistry Chemical Physics, 8, 4280-4293.

CBE

Snyder J, Skovsen E, Lambert JDC, Poulsen L, Ogilby PR. 2006. Optical detection of singlet oxygen from single cells. Physical Chemistry Chemical Physics. 8:4280-4293.

MLA

Snyder, John et al. "Optical detection of singlet oxygen from single cells". Physical Chemistry Chemical Physics. 2006, 8. 4280-4293.

Vancouver

Snyder J, Skovsen E, Lambert JDC, Poulsen L, Ogilby PR. Optical detection of singlet oxygen from single cells. Physical Chemistry Chemical Physics. 2006;8:4280-4293.

Author

Snyder, John ; Skovsen, Esben ; Lambert, John D. C. ; Poulsen, Lars ; Ogilby, Peter Remsen. / Optical detection of singlet oxygen from single cells. In: Physical Chemistry Chemical Physics. 2006 ; Vol. 8. pp. 4280-4293.

Bibtex

@article{97b6d9d0c65e11dbbee902004c4f4f50,
title = "Optical detection of singlet oxygen from single cells",
abstract = "The lowest excited electronic state of molecular oxygen, singlet molecular oxygen, O2(a 1g), is a reactive species involved in many chemical and biological processes. To better understand the roles played by singlet oxygen in biological systems, particularly at the sub-cellular level, optical tools have been developed to create and directly detect this transient state in time- and spatially-resolved experiments from single cells. Data obtained indicate that, contrary to common perception, this reactive species can be quite long-lived in a cell and, as such, can diffuse over appreciable distances including across the cell membrane into the extracellular environment. On one hand, these results demonstrate that the behavior of singlet oxygen in an intact cell can be significantly different from that inferred from model bulk studies. More generally, these results provide a new perspective for mechanistic studies of intra- and inter-cellular signaling and events that ultimately lead to photo-induced cell death.",
author = "John Snyder and Esben Skovsen and Lambert, {John D. C.} and Lars Poulsen and Ogilby, {Peter Remsen}",
year = "2006",
language = "English",
volume = "8",
pages = "4280--4293",
journal = "Physical Chemistry Chemical Physics",
issn = "1463-9076",
publisher = "ROYAL SOC CHEMISTRY",

}

RIS

TY - JOUR

T1 - Optical detection of singlet oxygen from single cells

AU - Snyder, John

AU - Skovsen, Esben

AU - Lambert, John D. C.

AU - Poulsen, Lars

AU - Ogilby, Peter Remsen

PY - 2006

Y1 - 2006

N2 - The lowest excited electronic state of molecular oxygen, singlet molecular oxygen, O2(a 1g), is a reactive species involved in many chemical and biological processes. To better understand the roles played by singlet oxygen in biological systems, particularly at the sub-cellular level, optical tools have been developed to create and directly detect this transient state in time- and spatially-resolved experiments from single cells. Data obtained indicate that, contrary to common perception, this reactive species can be quite long-lived in a cell and, as such, can diffuse over appreciable distances including across the cell membrane into the extracellular environment. On one hand, these results demonstrate that the behavior of singlet oxygen in an intact cell can be significantly different from that inferred from model bulk studies. More generally, these results provide a new perspective for mechanistic studies of intra- and inter-cellular signaling and events that ultimately lead to photo-induced cell death.

AB - The lowest excited electronic state of molecular oxygen, singlet molecular oxygen, O2(a 1g), is a reactive species involved in many chemical and biological processes. To better understand the roles played by singlet oxygen in biological systems, particularly at the sub-cellular level, optical tools have been developed to create and directly detect this transient state in time- and spatially-resolved experiments from single cells. Data obtained indicate that, contrary to common perception, this reactive species can be quite long-lived in a cell and, as such, can diffuse over appreciable distances including across the cell membrane into the extracellular environment. On one hand, these results demonstrate that the behavior of singlet oxygen in an intact cell can be significantly different from that inferred from model bulk studies. More generally, these results provide a new perspective for mechanistic studies of intra- and inter-cellular signaling and events that ultimately lead to photo-induced cell death.

M3 - Journal article

VL - 8

SP - 4280

EP - 4293

JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

SN - 1463-9076

ER -