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Lars Poulsen Tolbod

Automatic extraction of left ventricular mass and volumes using parametric images from non-ECG-gated 15O-water PET/CT

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Standard

Automatic extraction of left ventricular mass and volumes using parametric images from non-ECG-gated 15O-water PET/CT. / Nordström, J; Harms, Hans; Lubberink, Mark; Tolbod, Lars Poulsen; van den Berg, J; Baron, T; Flachskampf, F.A.; Kero, Tanja; Sørensen, Jens.

2017. Abstract from European Association of Nuclear Medicine Annual Congress, Vienna, Austria.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Harvard

Nordström, J, Harms, H, Lubberink, M, Tolbod, LP, van den Berg, J, Baron, T, Flachskampf, FA, Kero, T & Sørensen, J 2017, 'Automatic extraction of left ventricular mass and volumes using parametric images from non-ECG-gated 15O-water PET/CT', European Association of Nuclear Medicine Annual Congress, Vienna, Austria, 21/10/2017 - 25/10/2017. https://doi.org/10.1007/s00259-017-3822-1

APA

Nordström, J., Harms, H., Lubberink, M., Tolbod, L. P., van den Berg, J., Baron, T., Flachskampf, F. A., Kero, T., & Sørensen, J. (2017). Automatic extraction of left ventricular mass and volumes using parametric images from non-ECG-gated 15O-water PET/CT. Abstract from European Association of Nuclear Medicine Annual Congress, Vienna, Austria. https://doi.org/10.1007/s00259-017-3822-1

CBE

Nordström J, Harms H, Lubberink M, Tolbod LP, van den Berg J, Baron T, Flachskampf FA, Kero T, Sørensen J. 2017. Automatic extraction of left ventricular mass and volumes using parametric images from non-ECG-gated 15O-water PET/CT. Abstract from European Association of Nuclear Medicine Annual Congress, Vienna, Austria. https://doi.org/10.1007/s00259-017-3822-1

MLA

Nordström, J et al. Automatic extraction of left ventricular mass and volumes using parametric images from non-ECG-gated 15O-water PET/CT. European Association of Nuclear Medicine Annual Congress, 21 Oct 2017, Vienna, Austria, Conference abstract for conference, 2017. https://doi.org/10.1007/s00259-017-3822-1

Vancouver

Nordström J, Harms H, Lubberink M, Tolbod LP, van den Berg J, Baron T et al. Automatic extraction of left ventricular mass and volumes using parametric images from non-ECG-gated 15O-water PET/CT. 2017. Abstract from European Association of Nuclear Medicine Annual Congress, Vienna, Austria. https://doi.org/10.1007/s00259-017-3822-1

Author

Nordström, J ; Harms, Hans ; Lubberink, Mark ; Tolbod, Lars Poulsen ; van den Berg, J ; Baron, T ; Flachskampf, F.A. ; Kero, Tanja ; Sørensen, Jens. / Automatic extraction of left ventricular mass and volumes using parametric images from non-ECG-gated 15O-water PET/CT. Abstract from European Association of Nuclear Medicine Annual Congress, Vienna, Austria.

Bibtex

@conference{d5ab58d265684df9af87a172a2db4c57,
title = "Automatic extraction of left ventricular mass and volumes using parametric images from non-ECG-gated 15O-water PET/CT",
abstract = "Introduction: 15O-water positron emission tomography (PET) is considered the gold standard for non-invasive quantification of myocardial blood flow (MBF). It has been shown to identify patients with significant coronary artery disease (CAD) with high accuracy. Hypertrophy with or without dilatation of the myocardium together with a reduction in stroke volume are common in nearly any advanced cardiac disease. Thus, in addition to MBF, assessment of left-ventricular (LV) volumes and mass provides important diagnostic and prognostic information and are vital in the clinical setting. Therefore, the aim of the present study was to investigate the feasibility of measuring LV geometry using dynamic 15O-water PET/CT without ECG-gating. Methods: Parametric images of MBF, perfusable tissue fraction (PTF) and LV blood pool were generated automatically using kinetic modelling. Segmentation of the LV wall using PTF images generated regional MBF and PTF, and total ROI volume which was converted to LV mass (mLV). Segmentation of blood pool images generated LV end-diastolic (EDV) and end-systolic (ESV) volumes. Segmentation thresholds were studied analytically in a subset of patients. The generated values were combined to measure stroke volume (SV=EDV-ESV) and ejection fraction (EF=SV/EDV). Accuracy was determined by comparing PET to cardiac magnetic resonance (CMR) in 30 asymptomatic patients with high grade LV regurgitation (group A). Precision was determined as inter-observer variation in group A and by a test-retest PET study in 15 patients with suspected ischemic heart disease at rest (group B). Normal values were defined in nine healthy volunteers. Results: The accuracy of PET was good with correlations of r= 0.83, 0.88, 0.86 and 0.76 for mLV, EDV, ESV and SV, respectively, compared to CMR (P<0.001 for all). EF was in the normal range (53%-75%) and had a weaker correlation of r=0.51 (P=0.004). mLV was overestimated by 18%±13% compared to CMR and the residuals were closely related to the eccentric remodelling (mLV/EDV) defined by CMR. EDV, ESV and SV were underestimated by 10%±10%, 19%±13%, 3%±15%, respectively, compared to CMR. EF was overestimated by 4%±5% compared to CMR. Inter-observer correlation and test-retest repeatability were excellent (r>0.97). Normal values from PET were in line with normal values from a local CMR cohort. Conclusion: Microvascular function and LV geometry can be measured automatically with high accuracy and precision from a single non-gated 15O-water PET. The accuracy of mLV from PET is affected by LV eccentricity.",
author = "J Nordstr{\"o}m and Hans Harms and Mark Lubberink and Tolbod, {Lars Poulsen} and {van den Berg}, J and T Baron and F.A. Flachskampf and Tanja Kero and Jens S{\o}rensen",
year = "2017",
doi = "10.1007/s00259-017-3822-1",
language = "English",
note = "null ; Conference date: 21-10-2017 Through 25-10-2017",
url = "http://eanm17.eanm.org",

}

RIS

TY - ABST

T1 - Automatic extraction of left ventricular mass and volumes using parametric images from non-ECG-gated 15O-water PET/CT

AU - Nordström, J

AU - Harms, Hans

AU - Lubberink, Mark

AU - Tolbod, Lars Poulsen

AU - van den Berg, J

AU - Baron, T

AU - Flachskampf, F.A.

AU - Kero, Tanja

AU - Sørensen, Jens

PY - 2017

Y1 - 2017

N2 - Introduction: 15O-water positron emission tomography (PET) is considered the gold standard for non-invasive quantification of myocardial blood flow (MBF). It has been shown to identify patients with significant coronary artery disease (CAD) with high accuracy. Hypertrophy with or without dilatation of the myocardium together with a reduction in stroke volume are common in nearly any advanced cardiac disease. Thus, in addition to MBF, assessment of left-ventricular (LV) volumes and mass provides important diagnostic and prognostic information and are vital in the clinical setting. Therefore, the aim of the present study was to investigate the feasibility of measuring LV geometry using dynamic 15O-water PET/CT without ECG-gating. Methods: Parametric images of MBF, perfusable tissue fraction (PTF) and LV blood pool were generated automatically using kinetic modelling. Segmentation of the LV wall using PTF images generated regional MBF and PTF, and total ROI volume which was converted to LV mass (mLV). Segmentation of blood pool images generated LV end-diastolic (EDV) and end-systolic (ESV) volumes. Segmentation thresholds were studied analytically in a subset of patients. The generated values were combined to measure stroke volume (SV=EDV-ESV) and ejection fraction (EF=SV/EDV). Accuracy was determined by comparing PET to cardiac magnetic resonance (CMR) in 30 asymptomatic patients with high grade LV regurgitation (group A). Precision was determined as inter-observer variation in group A and by a test-retest PET study in 15 patients with suspected ischemic heart disease at rest (group B). Normal values were defined in nine healthy volunteers. Results: The accuracy of PET was good with correlations of r= 0.83, 0.88, 0.86 and 0.76 for mLV, EDV, ESV and SV, respectively, compared to CMR (P<0.001 for all). EF was in the normal range (53%-75%) and had a weaker correlation of r=0.51 (P=0.004). mLV was overestimated by 18%±13% compared to CMR and the residuals were closely related to the eccentric remodelling (mLV/EDV) defined by CMR. EDV, ESV and SV were underestimated by 10%±10%, 19%±13%, 3%±15%, respectively, compared to CMR. EF was overestimated by 4%±5% compared to CMR. Inter-observer correlation and test-retest repeatability were excellent (r>0.97). Normal values from PET were in line with normal values from a local CMR cohort. Conclusion: Microvascular function and LV geometry can be measured automatically with high accuracy and precision from a single non-gated 15O-water PET. The accuracy of mLV from PET is affected by LV eccentricity.

AB - Introduction: 15O-water positron emission tomography (PET) is considered the gold standard for non-invasive quantification of myocardial blood flow (MBF). It has been shown to identify patients with significant coronary artery disease (CAD) with high accuracy. Hypertrophy with or without dilatation of the myocardium together with a reduction in stroke volume are common in nearly any advanced cardiac disease. Thus, in addition to MBF, assessment of left-ventricular (LV) volumes and mass provides important diagnostic and prognostic information and are vital in the clinical setting. Therefore, the aim of the present study was to investigate the feasibility of measuring LV geometry using dynamic 15O-water PET/CT without ECG-gating. Methods: Parametric images of MBF, perfusable tissue fraction (PTF) and LV blood pool were generated automatically using kinetic modelling. Segmentation of the LV wall using PTF images generated regional MBF and PTF, and total ROI volume which was converted to LV mass (mLV). Segmentation of blood pool images generated LV end-diastolic (EDV) and end-systolic (ESV) volumes. Segmentation thresholds were studied analytically in a subset of patients. The generated values were combined to measure stroke volume (SV=EDV-ESV) and ejection fraction (EF=SV/EDV). Accuracy was determined by comparing PET to cardiac magnetic resonance (CMR) in 30 asymptomatic patients with high grade LV regurgitation (group A). Precision was determined as inter-observer variation in group A and by a test-retest PET study in 15 patients with suspected ischemic heart disease at rest (group B). Normal values were defined in nine healthy volunteers. Results: The accuracy of PET was good with correlations of r= 0.83, 0.88, 0.86 and 0.76 for mLV, EDV, ESV and SV, respectively, compared to CMR (P<0.001 for all). EF was in the normal range (53%-75%) and had a weaker correlation of r=0.51 (P=0.004). mLV was overestimated by 18%±13% compared to CMR and the residuals were closely related to the eccentric remodelling (mLV/EDV) defined by CMR. EDV, ESV and SV were underestimated by 10%±10%, 19%±13%, 3%±15%, respectively, compared to CMR. EF was overestimated by 4%±5% compared to CMR. Inter-observer correlation and test-retest repeatability were excellent (r>0.97). Normal values from PET were in line with normal values from a local CMR cohort. Conclusion: Microvascular function and LV geometry can be measured automatically with high accuracy and precision from a single non-gated 15O-water PET. The accuracy of mLV from PET is affected by LV eccentricity.

U2 - 10.1007/s00259-017-3822-1

DO - 10.1007/s00259-017-3822-1

M3 - Conference abstract for conference

C2 - 28894880

Y2 - 21 October 2017 through 25 October 2017

ER -