Lars Jørgen Østergaard

TLR-mediated NF-kB-dependent cytokine production is differently affected by HIV therapeutics

Research output: Contribution to conferencePosterResearch

  • The Department of Infectious Diseases
  • Department of Medical Microbiology and Immunology

Pathogen-recognizing Toll-like receptors 2 (TLR2) and TLR4 are known to recognize a number of pathogens, including E.Coli, S. Pneumonia and N. Meningococcus. We have studied whether a number of HIV therapeutics affect immediate proinflammatory cytokine responses in cell cultures. Preliminary results suggest an opposing effect of the drugs Tenofovir and Retrovir (AZT) on TLR-mediated production of NF-kappaB-dependent proinflammatory cytokines. We present data on the mechanisms behind the drug-mediated remodeling of innate immune activation and how the drugs effect early host-pathogen interactions.

Original languageEnglish
Publication year2008
Publication statusPublished - 2008
EventToll2008 meeting - Lissabon, Portugal
Duration: 24 Aug 200827 Sep 2008


ConferenceToll2008 meeting

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ID: 15162851