Lars Jørgen Østergaard

The impact of B-cell perturbations on pneumococcal conjugate vaccine response in HIV-infected adults

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Untreated HIV infection results in severe perturbations of the B-cell population and hyporesponsiveness to vaccination. We studied associations between circulating B-cell subsets and antibody response to pneumococcal conjugate vaccine in treated and untreated HIV patients.Ninety-five HIV-infected adults were grouped according to antiretroviral therapy (ART) and CD4+ cell count as follows: 20 ART-naïve (no prior ART), 62 ART-responders (received ART, and CD4 count >500 cells/µl), and 13 impaired responders (received ART for more than 3 years, and CD4 count
Original languageEnglish
JournalP L o S One
Pages (from-to)e42307
Publication statusPublished - 2012

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