Lars Jørgen Østergaard

T-cell and B-cell perturbations identify distinct differences in HIV-2 compared with HIV-1-induced immunodeficiency

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BACKGROUND: For unknown reasons, HIV-2 is less pathogenic than HIV-1, and HIV-2-induced immunodeficiency may be different from that caused by HIV-1. Previous immunological studies have hinted at possible shifts in both T-cell and B-cell subsets, which we aimed to characterize further. METHODS: From an HIV clinic in Guinea-Bissau, 63 HIV-2, 83 HIV-1, and 26 HIV-negative participants were included. All HIV-infected participants were ART-naive. The following cell subsets were analysed by flow cytometry; T cells (maturation and activation), regulatory T cells, and B cells (maturation and activation). RESULTS: After standardizing for sex, age, and CD4 T-cell count HIV-2 had 0.938 log10 copies/ml lower HIV RNA levels than the HIV-1-infected patients. Whereas T-cell maturation and regulatory T-cell profiles were similar between patients, HIV-2-infected patients had higher proportions of CD8CD28 and lower proportions of CD8PD-1+ T cells than HIV-1-infected patients. This finding was independent of HIV RNA levels. HIV-2 was also associated with a more preserved proportion of naive B cells. CONCLUSION: HIV-2 is characterized by lower viral load, and lower T-cell activation, which may account for the slower disease progression.

Original languageEnglish
JournalAIDS (London, England)
Volume33
Issue7
Pages (from-to)1131-1141
Number of pages11
ISSN0269-9370
DOIs
Publication statusPublished - 2019

    Research areas

  • B cell, CD28 EXPRESSION, DISEASE PROGRESSION, GUINEA-BISSAU, Guinea-Bissau, HIV, HIV-1, HIV-2, IMMUNE ACTIVATION, INFECTED INDIVIDUALS, NEUTRALIZING ANTIBODY-RESPONSES, PREVALENCE, REPLICATIVE SENESCENCE, T cell, VIRAL LOAD, VIRUS TYPE-2 HIV-2, activation, leukocyte, maturation, phenotype

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