Lars Jørgen Østergaard

T-cell and B-cell perturbations are similar in ART-naive HIV-1 and HIV-1/2 dually infected patients

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Bo L. Hønge
  • Mikkel S. Petersen
  • Sanne Jespersen, Bandim Health Project
  • ,
  • Candida Medina, Ministry of Health
  • ,
  • David D.S. Té, Ministry of Health
  • ,
  • Bertram Kjerulff
  • Mads M. Jensen, Bandim Health Project
  • ,
  • Ditte Steiniche, Bandim Health Project, Aarhus University Hospital
  • ,
  • Joakim Esbjörnsson, Lunds Universitet, Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
  • ,
  • Alex L. Laursen
  • Christian Wejse
  • Henrik Krarup, Section of Molecular Diagnostics, Aalborg University
  • ,
  • Bjarne K. Møller
  • Christian Erikstrup
  • Bissau HIV cohort study group

BACKGROUND: HIV-2 may slow progression of a subsequently acquired HIV-1 infection through cross-neutralizing antibodies and polyfunctional CD8 T cells. We hypothesized that HIV-1/2 dually infected patients compared with HIV-1-infected patients had more preserved immune maturation subsets and less immune activation of T and B cells. METHODS: ART-naive patients with HIV-1 (n = 83) or HIV-1/2 dual (n = 27) infections were included in this cross-sectional study at an HIV clinic in Guinea-Bissau. Peripheral blood mononuclear cells (PBMCs) were analyzed by flow cytometry according to T-cell maturation and activation, regulatory T-cell fraction, and B-cell maturation and activation. RESULTS: HIV-1/2 dually infected patients had lower levels of HIV-1 RNA compared with patients with HIV-1 infection, but the levels of total HIV RNA (HIV-1 and HIV-2) were similar in the two patient groups. T-cell maturation, and proportions of regulatory T cells (FoxP3+) were also similar in the two groups. HIV-1/2 dually infected patients had higher proportions of CD4 and CD8 T cells positive for the activation marker CD38, but there was no difference in other T-cell activation markers (CD28, CTLA-4, PD-1). HIV-1/2 dually infected patients also had higher proportions of IgM-only B cells and plasmablasts. CONCLUSION: HIV-1/2 was not associated with less immune perturbations than for HIV-1 infection.

Original languageEnglish
JournalAIDS (London, England)
Volume33
Issue7
Pages (from-to)1143-1153
Number of pages11
ISSN0269-9370
DOIs
Publication statusPublished - 2019

    Research areas

  • B cell, DISEASE PROGRESSION, GUINEA-BISSAU, Guinea-Bissau, HIV 2, HIV-1, HIV-1/2 dual infection, IMMUNE ACTIVATION, IMMUNODEFICIENCY-VIRUS TYPE-2, INDIVIDUALS, MORTALITY, PHENOTYPE, PREVALENCE, T cell, VIRAL LOAD, WEST-AFRICA, activation, leukocyte, maturation, phenotype

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