Lars Jørgen Østergaard

Soluble Macrophage Mannose Receptor (sCD206/sMR) as a Biomarker in HIV-infection

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Macrophages play important roles during HIV-infection, reflected by changes in macrophage-activation biomarker sCD163. Here, we present data on the novel macrophage-activation biomarker soluble mannose receptor/CD206 (sMR/sCD206) in HIV-infection.We investigated sCD206 blood levels at baseline and follow-up with/without ART, in 212 patients with HIV-1, HIV-2, or dual infection.At baseline, there was no difference in sCD206 level between HIV-types, and sCD206 was unchanged at follow-up without ART. However, contrary to sCD163, sCD206 levels decreased significantly for both HIV-1 and HIV-2, but not for HIV-1/2 patients, during ART. Further investigations are needed to establish sCD206 as biomarker in HIV-infection.

Original languageEnglish
JournalThe Journal of Infectious Diseases
Pages (from-to)1291-1295
Number of pages5
Publication statusPublished - Sep 2018

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