Lars Jørgen Østergaard

Severe morbidity after antiretroviral (ART) initiation: active surveillance in HIV care programs, the IeDEA West Africa collaboration

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Severe morbidity after antiretroviral (ART) initiation : active surveillance in HIV care programs, the IeDEA West Africa collaboration. / Abo, Yao; Zannou Djimon, Marcel; Messou, Eugène; Balestre, Eric; Kouakou, Martial; Akakpo, Jocelyn; Ahouada, Carin; de Rekeneire, Nathalie; Dabis, François; Lewden, Charlotte; Minga, Albert; IeDEA West Africa Collaboration (Christian Erikstrup, Alex Lund Laursen, Lars Østergaard; members).

In: B M C Infectious Diseases, Vol. 15, 2015, p. 176.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Abo, Y, Zannou Djimon, M, Messou, E, Balestre, E, Kouakou, M, Akakpo, J, Ahouada, C, de Rekeneire, N, Dabis, F, Lewden, C, Minga, A & IeDEA West Africa Collaboration (Christian Erikstrup, Alex Lund Laursen, Lars Østergaard; members) 2015, 'Severe morbidity after antiretroviral (ART) initiation: active surveillance in HIV care programs, the IeDEA West Africa collaboration', B M C Infectious Diseases, vol. 15, pp. 176. https://doi.org/10.1186/s12879-015-0910-3

APA

Abo, Y., Zannou Djimon, M., Messou, E., Balestre, E., Kouakou, M., Akakpo, J., Ahouada, C., de Rekeneire, N., Dabis, F., Lewden, C., Minga, A., & IeDEA West Africa Collaboration (Christian Erikstrup, Alex Lund Laursen, Lars Østergaard; members) (2015). Severe morbidity after antiretroviral (ART) initiation: active surveillance in HIV care programs, the IeDEA West Africa collaboration. B M C Infectious Diseases, 15, 176. https://doi.org/10.1186/s12879-015-0910-3

CBE

Abo Y, Zannou Djimon M, Messou E, Balestre E, Kouakou M, Akakpo J, Ahouada C, de Rekeneire N, Dabis F, Lewden C, Minga A, IeDEA West Africa Collaboration (Christian Erikstrup, Alex Lund Laursen, Lars Østergaard; members). 2015. Severe morbidity after antiretroviral (ART) initiation: active surveillance in HIV care programs, the IeDEA West Africa collaboration. B M C Infectious Diseases. 15:176. https://doi.org/10.1186/s12879-015-0910-3

MLA

Vancouver

Author

Abo, Yao ; Zannou Djimon, Marcel ; Messou, Eugène ; Balestre, Eric ; Kouakou, Martial ; Akakpo, Jocelyn ; Ahouada, Carin ; de Rekeneire, Nathalie ; Dabis, François ; Lewden, Charlotte ; Minga, Albert ; IeDEA West Africa Collaboration (Christian Erikstrup, Alex Lund Laursen, Lars Østergaard; members). / Severe morbidity after antiretroviral (ART) initiation : active surveillance in HIV care programs, the IeDEA West Africa collaboration. In: B M C Infectious Diseases. 2015 ; Vol. 15. pp. 176.

Bibtex

@article{82cdd42bac5c4d7fa59a172e352a9304,
title = "Severe morbidity after antiretroviral (ART) initiation: active surveillance in HIV care programs, the IeDEA West Africa collaboration",
abstract = "BACKGROUND: The causes of severe morbidity in health facilities implementing Antiretroviral Treatment (ART) programmes are poorly documented in sub-Saharan Africa. We aimed to describe severe morbidity among HIV-infected patients after ART initiation, based on data from an active surveillance system established within a network of specialized care facilities in West African cities.METHODS: Within the International epidemiological Database to Evaluate AIDS (IeDEA)--West Africa collaboration, we conducted a prospective, multicenter data collection that involved two facilities in Abidjan, C{\^o}te d'Ivoire and one in Cotonou, Benin. Among HIV-infected adults receiving ART, events were recorded using a standardized form. A simple case-definition of severe morbidity (death, hospitalization, fever>38°5C, Karnofsky index<70%) was used at any patient contact point. Then a physician confirmed and classified the event as WHO stage 3 or 4 according to the WHO clinical classification or as degree 3 or 4 of the ANRS scale.RESULTS: From December 2009 to December 2011, 978 adults (71% women, median age 39 years) presented with 1449 severe events. The main diagnoses were: non-AIDS-defining infections (33%), AIDS-defining illnesses (33%), suspected adverse drug reactions (7%), other illnesses (4%) and syndromic diagnoses (16%). The most common specific diagnoses were: malaria (25%), pneumonia (13%) and tuberculosis (8%). The diagnoses were reported as syndromic in one out of five events recorded during this study.CONCLUSIONS: This study highlights the ongoing importance of conventional infectious diseases among severe morbid events occurring in patients on ART in ambulatory HIV care facilities in West Africa. Meanwhile, additional studies are needed due to the undiagnosed aspect of severe morbidity in substantial proportion.",
author = "Yao Abo and {Zannou Djimon}, Marcel and Eug{\`e}ne Messou and Eric Balestre and Martial Kouakou and Jocelyn Akakpo and Carin Ahouada and {de Rekeneire}, Nathalie and Fran{\c c}ois Dabis and Charlotte Lewden and Albert Minga and {IeDEA West Africa Collaboration (Christian Erikstrup, Alex Lund Laursen, Lars {\O}stergaard; members)} and {\O}stergaard, {Lars J{\o}rgen} and Christian Erikstrup and Laursen, {Alex Lund}",
year = "2015",
doi = "10.1186/s12879-015-0910-3",
language = "English",
volume = "15",
pages = "176",
journal = "B M C Infectious Diseases",
issn = "1471-2334",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Severe morbidity after antiretroviral (ART) initiation

T2 - active surveillance in HIV care programs, the IeDEA West Africa collaboration

AU - Abo, Yao

AU - Zannou Djimon, Marcel

AU - Messou, Eugène

AU - Balestre, Eric

AU - Kouakou, Martial

AU - Akakpo, Jocelyn

AU - Ahouada, Carin

AU - de Rekeneire, Nathalie

AU - Dabis, François

AU - Lewden, Charlotte

AU - Minga, Albert

AU - IeDEA West Africa Collaboration (Christian Erikstrup, Alex Lund Laursen, Lars Østergaard; members)

AU - Østergaard, Lars Jørgen

AU - Erikstrup, Christian

AU - Laursen, Alex Lund

PY - 2015

Y1 - 2015

N2 - BACKGROUND: The causes of severe morbidity in health facilities implementing Antiretroviral Treatment (ART) programmes are poorly documented in sub-Saharan Africa. We aimed to describe severe morbidity among HIV-infected patients after ART initiation, based on data from an active surveillance system established within a network of specialized care facilities in West African cities.METHODS: Within the International epidemiological Database to Evaluate AIDS (IeDEA)--West Africa collaboration, we conducted a prospective, multicenter data collection that involved two facilities in Abidjan, Côte d'Ivoire and one in Cotonou, Benin. Among HIV-infected adults receiving ART, events were recorded using a standardized form. A simple case-definition of severe morbidity (death, hospitalization, fever>38°5C, Karnofsky index<70%) was used at any patient contact point. Then a physician confirmed and classified the event as WHO stage 3 or 4 according to the WHO clinical classification or as degree 3 or 4 of the ANRS scale.RESULTS: From December 2009 to December 2011, 978 adults (71% women, median age 39 years) presented with 1449 severe events. The main diagnoses were: non-AIDS-defining infections (33%), AIDS-defining illnesses (33%), suspected adverse drug reactions (7%), other illnesses (4%) and syndromic diagnoses (16%). The most common specific diagnoses were: malaria (25%), pneumonia (13%) and tuberculosis (8%). The diagnoses were reported as syndromic in one out of five events recorded during this study.CONCLUSIONS: This study highlights the ongoing importance of conventional infectious diseases among severe morbid events occurring in patients on ART in ambulatory HIV care facilities in West Africa. Meanwhile, additional studies are needed due to the undiagnosed aspect of severe morbidity in substantial proportion.

AB - BACKGROUND: The causes of severe morbidity in health facilities implementing Antiretroviral Treatment (ART) programmes are poorly documented in sub-Saharan Africa. We aimed to describe severe morbidity among HIV-infected patients after ART initiation, based on data from an active surveillance system established within a network of specialized care facilities in West African cities.METHODS: Within the International epidemiological Database to Evaluate AIDS (IeDEA)--West Africa collaboration, we conducted a prospective, multicenter data collection that involved two facilities in Abidjan, Côte d'Ivoire and one in Cotonou, Benin. Among HIV-infected adults receiving ART, events were recorded using a standardized form. A simple case-definition of severe morbidity (death, hospitalization, fever>38°5C, Karnofsky index<70%) was used at any patient contact point. Then a physician confirmed and classified the event as WHO stage 3 or 4 according to the WHO clinical classification or as degree 3 or 4 of the ANRS scale.RESULTS: From December 2009 to December 2011, 978 adults (71% women, median age 39 years) presented with 1449 severe events. The main diagnoses were: non-AIDS-defining infections (33%), AIDS-defining illnesses (33%), suspected adverse drug reactions (7%), other illnesses (4%) and syndromic diagnoses (16%). The most common specific diagnoses were: malaria (25%), pneumonia (13%) and tuberculosis (8%). The diagnoses were reported as syndromic in one out of five events recorded during this study.CONCLUSIONS: This study highlights the ongoing importance of conventional infectious diseases among severe morbid events occurring in patients on ART in ambulatory HIV care facilities in West Africa. Meanwhile, additional studies are needed due to the undiagnosed aspect of severe morbidity in substantial proportion.

U2 - 10.1186/s12879-015-0910-3

DO - 10.1186/s12879-015-0910-3

M3 - Journal article

C2 - 25885859

VL - 15

SP - 176

JO - B M C Infectious Diseases

JF - B M C Infectious Diseases

SN - 1471-2334

ER -