Lars Jørgen Østergaard

Risk of hospitalization for cardiovascular disease after use of macrolides and penicillins: a comparative prospective cohort study

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  • Regionshospitalet Viborg
  • The Department of Infectious Diseases
  • Department of Clinical Epidemiology
Chlamydia pneumoniae has been associated with cardiovascular diseases, and C. pneumoniae infection is treatable with macrolides. In this comparative cohort study, 634 users of macrolides and 3827 users of penicillins were identified from the Danish Health Service Registry of Prescriptions and followed up for an average of 6 months. The patients were then linked to the Regional Hospital Discharge Registry to assess the outcome of hospitalization for cardiovascular disease. In the first 3 months, the relative risk (RR) of admission for a cardiovascular disease was 0.48 (95% confidence interval, 0.27-0.88) in users of macrolides compared with users of penicillins. No difference was seen after 3 months. Interaction analyses indicated that the lower risk seen in users of macrolides could be more pronounced in patients without versus those with a previous cardiovascular disease (RR, 0.39 vs. 0.52), in patients >or=60 versus <60 years old (RR, 0.39 vs. 0.64), and in men versus women (RR, 0.35 vs. 0.67).
Original languageEnglish
JournalJournal of Infectious Diseases
Volume183
Issue11
Pages (from-to)1625-30
Number of pages5
ISSN0022-1899
DOIs
Publication statusPublished - 2001

    Research areas

  • Aged, Anti-Bacterial Agents, Cardiovascular Diseases, Chlamydia Infections, Cohort Studies, Denmark, Female, Hospitalization, Humans, Macrolides, Male, Middle Aged, Penicillins, Prospective Studies, Risk Factors

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