Lars Jørgen Østergaard

Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau: a cross-sectional study

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  • Helene L Grønborg, Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau., GloHAU, Center for Global Health, Department of Public Health, Aarhus University, Aarhus
  • ,
  • Sanne Jespersen
  • Johanne H Egedal
  • Faustino G Correia, National HIV Programme, Ministry of Health, Bissau, Guinea-Bissau.
  • ,
  • Candida Medina, National HIV Programme, Ministry of Health, Bissau, Guinea-Bissau.
  • ,
  • Henrik Krarup, Aalborg University
  • ,
  • Bo L Hønge
  • Christian Wejse
  • Lars Jørgen Østergaard (Member of author collaboration)
  • Bissau HIV cohort study group

OBJECTIVES: To describe the prevalence of CMV in a cohort of HIV infected individuals in Guinea-Bissau, West Africa and to evaluate differences in patients' clinical characteristics associated with their CMV status.

METHODS: Newly diagnosed HIV infected adults were invited to participate in this cross-sectional study, from May until December 2015. Enrolled patients were interviewed and underwent a full physical examination focusing on CMV disease manifestations. Blood samples were analysed for CMV serology, QuantiFERON-CMV response and CMV DNA. Mortality follow-up were registered for one year after inclusion.

RESULTS: In total, 180 patients were enrolled. Anti-CMV IgG positivity was found in 100% (138/138) and 2.8% (4/138) were anti-CMV IgM positive. A positive QuantiFERON-CMV response was found in 85.7% (60/70) of the patients and 60.6% (83/137) had CMV viraemia. QuantiFERON-CMV response and detectable CMV DNA were associated with lower CD4 cell count, older age and upper gastrointestinal complaints. During one year of follow-up, the IRR for death among CMV DNA positive patients was 1.5 (P = 0.5).

CONCLUSIONS: CMV coinfection was detected among all enrolled patients and CMV viraemia was highly prevalent. Only age and upper gastrointestinal complaints were associated with the patients' CMV status.

Original languageEnglish
JournalTropical Medicine & International Health
Publication statusPublished - 31 Aug 2018

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