Lars Jørgen Østergaard

Predicting the risk of cardiovascular disease in HIV-infected patients: the data collection on adverse effects of anti-HIV drugs study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Nina Friis-Møller
  • ,
  • Rodolphe Thiébaut
  • ,
  • Peter Reiss
  • ,
  • Rainer Weber, Unknown
  • Antonella D'Arminio Monforte
  • ,
  • Stephane De Wit
  • ,
  • Wafaa El-Sadr
  • ,
  • Eric Fontas, Unknown
  • Signe Worm
  • ,
  • Ole Kirk
  • ,
  • Andrew Phillips
  • ,
  • Caroline A Sabin
  • ,
  • Jens D Lundgren
  • ,
  • Matthew G Law, Unknown
  • DAD study group (Lars Østergaard, member)

AIMS: HIV-infected patients receiving combination antiretroviral therapy may experience metabolic complications, potentially increasing their risk of cardiovascular diseases (CVDs). Furthermore, exposures to some antiretroviral drugs seem to be independently associated with increased CVD risk. We aimed to develop cardiovascular risk-assessment models tailored to HIV-infected patients.

METHODS AND RESULTS: Prospective multinational cohort study. The data set included 22,625 HIV-infected patients from 20 countries in Europe and Australia who were free of CVD at entry into the Data collection on Adverse Effects of Anti-HIV Drugs Study. Using cross-validation methods, separate models were developed to predict the risk of myocardial infarction, coronary heart disease, and a composite CVD endpoint. Model performance was compared with the Framingham score. The models included age, sex, systolic blood pressure, smoking status, family history of CVD, diabetes, total cholesterol, HDL cholesterol and indinavir, lopinavir/r and abacavir exposure. The models performed well with area under the receiver operator curve statistics of 0.783 (range 0.642-0.820) for myocardial infarction, 0.776 (0.670-0.818) for coronary heart disease and 0.769 (0.695-0.824) for CVD. The models estimated more accurately the outcomes in the subgroups than the Framingham score.

CONCLUSION: Risk equations developed from a population of HIV-infected patients, incorporating routinely collected cardiovascular risk parameters and exposure to individual antiretroviral therapy drugs, might be more useful in estimating CVD risks in HIV-infected persons than conventional risk prediction models.

Original languageEnglish
JournalEuropean Journal of Preventive Cardiology
Pages (from-to)491-501
Number of pages11
Publication statusPublished - Oct 2010

    Research areas

  • Adult, Anti-HIV Agents, Argentina, Australia, Coronary Disease, Drug Therapy, Combination, Europe, Female, HIV Infections, Humans, Male, Middle Aged, Models, Statistical, Myocardial Infarction, Prospective Studies, Reproducibility of Results, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome

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