Lars Jørgen Østergaard

Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau

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Cryptococcal antigenemia may precede development of cryptococcal meningitis and death among patients with advanced HIV infection. Among 200 retrospectively and randomly selected ART-naïve patients with CD4 counts < 100 cells/µl from Guinea-Bissau, 20 (10%) had a positive cryptococcal antigen test. Self-reported headache and fever were predictors of a positive test, while cryptococcal antigenemia was a strong predictor of death within the first year of follow-up, MRR 2.22 (95% CI: 1.15-4.30). Screening for cryptococcal antigenemia should be implemented for patients with advanced HIV in Guinea-Bissau. Pre-emptive anti-fungal therapy should be initiated prior to ART-initiation if the screening is positive.

Original languageEnglish
Article number18
JournalPan African Medical Journal
Volume29
Pages (from-to)18
ISSN1937-8688
DOIs
Publication statusPublished - 2018

    Research areas

  • AIDS-Related Opportunistic Infections/diagnosis, Adult, Antigens, Fungal/blood, CD4 Lymphocyte Count, Cryptococcus/isolation & purification, Female, Follow-Up Studies, Guinea-Bissau, HIV Infections/complications, Humans, Male, Meningitis, Cryptococcal/diagnosis, Retrospective Studies, Lateral flow assay, Antigen screening, Cryptococcal meningitis, HIV, Cryptococcal antigenemia

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