Lars Jørgen Østergaard

Incidence and Mortality of Herpes Simplex Encephalitis in Denmark: a nationwide registry-based cohort study

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Incidence and Mortality of Herpes Simplex Encephalitis in Denmark : a nationwide registry-based cohort study. / Jørgensen, Laura Krogh; Dalgaard, Lars Skov; Østergaard, Lars Jørgen; Nørgaard, Mette; Mogensen, Trine Hyrup.

In: The Journal of infection, 04.10.2016.

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@article{d89e88ad37ae4cc5b1c58275faeb53b5,
title = "Incidence and Mortality of Herpes Simplex Encephalitis in Denmark: a nationwide registry-based cohort study",
abstract = "OBJECTIVES: We aimed to investigate the incidence and mortality of herpes simplex encephalitis (HSE) in a nationwide cohort.METHODS: From the Danish National Patient Registry, we identified all adults hospitalised with a first-time diagnosis of HSE in Denmark during 2004-2014. The HSE diagnoses were verified using medical records and microbiological data. Patients were followed for mortality through the Danish Civil Registry System. We estimated age-standardised incidence rates of HSE and 30-day, 60-day, and 1-year cumulative mortality. Furthermore, we assessed whether calendar year, age, gender, level of comorbidity, virus type, and department type was associated with HSE mortality.RESULTS: We identified a total of 230 cases of HSE. Median age was 60.7 years (interquartile range: 49.3-71.6). The overall incidence rate was 4.64 cases per million population per year (95% confidence interval: 4.06-5.28). The cumulative mortality within 30 days, 60 days, and 1 year of the HSE admission was 8.3%, 11.3%, and 18.6%, respectively. Advanced age and presence of comorbidity was associated with increased 60-day and 1-year mortality.CONCLUSIONS: This nationwide study of verified HSE found a higher incidence than reported in previous nationwide studies. Presence of comorbidity were identified as a novel adverse prognostic factors. Mortality rates following HSE remain high.",
author = "J{\o}rgensen, {Laura Krogh} and Dalgaard, {Lars Skov} and {\O}stergaard, {Lars J{\o}rgen} and Mette N{\o}rgaard and Mogensen, {Trine Hyrup}",
note = "Copyright {\textcopyright} 2016 The British Infection Association. Published by Elsevier Ltd. All rights reserved.",
year = "2016",
month = oct,
day = "4",
doi = "10.1016/j.jinf.2016.09.004",
language = "English",
journal = "Journal of Infection",
issn = "0163-4453",
publisher = "W.B.Saunders Co. Ltd.",

}

RIS

TY - JOUR

T1 - Incidence and Mortality of Herpes Simplex Encephalitis in Denmark

T2 - a nationwide registry-based cohort study

AU - Jørgensen, Laura Krogh

AU - Dalgaard, Lars Skov

AU - Østergaard, Lars Jørgen

AU - Nørgaard, Mette

AU - Mogensen, Trine Hyrup

N1 - Copyright © 2016 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

PY - 2016/10/4

Y1 - 2016/10/4

N2 - OBJECTIVES: We aimed to investigate the incidence and mortality of herpes simplex encephalitis (HSE) in a nationwide cohort.METHODS: From the Danish National Patient Registry, we identified all adults hospitalised with a first-time diagnosis of HSE in Denmark during 2004-2014. The HSE diagnoses were verified using medical records and microbiological data. Patients were followed for mortality through the Danish Civil Registry System. We estimated age-standardised incidence rates of HSE and 30-day, 60-day, and 1-year cumulative mortality. Furthermore, we assessed whether calendar year, age, gender, level of comorbidity, virus type, and department type was associated with HSE mortality.RESULTS: We identified a total of 230 cases of HSE. Median age was 60.7 years (interquartile range: 49.3-71.6). The overall incidence rate was 4.64 cases per million population per year (95% confidence interval: 4.06-5.28). The cumulative mortality within 30 days, 60 days, and 1 year of the HSE admission was 8.3%, 11.3%, and 18.6%, respectively. Advanced age and presence of comorbidity was associated with increased 60-day and 1-year mortality.CONCLUSIONS: This nationwide study of verified HSE found a higher incidence than reported in previous nationwide studies. Presence of comorbidity were identified as a novel adverse prognostic factors. Mortality rates following HSE remain high.

AB - OBJECTIVES: We aimed to investigate the incidence and mortality of herpes simplex encephalitis (HSE) in a nationwide cohort.METHODS: From the Danish National Patient Registry, we identified all adults hospitalised with a first-time diagnosis of HSE in Denmark during 2004-2014. The HSE diagnoses were verified using medical records and microbiological data. Patients were followed for mortality through the Danish Civil Registry System. We estimated age-standardised incidence rates of HSE and 30-day, 60-day, and 1-year cumulative mortality. Furthermore, we assessed whether calendar year, age, gender, level of comorbidity, virus type, and department type was associated with HSE mortality.RESULTS: We identified a total of 230 cases of HSE. Median age was 60.7 years (interquartile range: 49.3-71.6). The overall incidence rate was 4.64 cases per million population per year (95% confidence interval: 4.06-5.28). The cumulative mortality within 30 days, 60 days, and 1 year of the HSE admission was 8.3%, 11.3%, and 18.6%, respectively. Advanced age and presence of comorbidity was associated with increased 60-day and 1-year mortality.CONCLUSIONS: This nationwide study of verified HSE found a higher incidence than reported in previous nationwide studies. Presence of comorbidity were identified as a novel adverse prognostic factors. Mortality rates following HSE remain high.

U2 - 10.1016/j.jinf.2016.09.004

DO - 10.1016/j.jinf.2016.09.004

M3 - Journal article

C2 - 27717782

JO - Journal of Infection

JF - Journal of Infection

SN - 0163-4453

ER -