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Lars Jørgen Østergaard

Impact of Minority Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutations on Resistance Genotype after Virologic Failure

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Jonathan Z Li
  • ,
  • Roger Paredes
  • ,
  • Heather Ribaudo
  • ,
  • Michael J Kozal
  • ,
  • Evguenia S Svarovskaia
  • ,
  • Jeffrey A Johnson
  • ,
  • Anna Maria Geretti
  • ,
  • Karin J Metzner
  • ,
  • Martin Roelsgaard Jakobsen
  • Katherine Huppler Hullsiek
  • ,
  • Lars Jørgen Østergaard
  • Michael D Miller
  • ,
  • Daniel R Kuritzkes
Drug-resistant HIV-1 minority variants increase the risk of virologic failure for first-line NNRTI-based regimens. We performed a pooled analysis to evaluate the relationship between NNRTI-resistant minority variants and the likelihood and types of resistance mutations detected at virologic failure. In multivariable logistic regression analysis, higher NNRTI minority variant copy numbers, non-white race, and nevirapine use were associated with a higher risk of NNRTI resistance at virologic failure. Among participants on efavirenz, K103N was the most frequently observed resistance mutation at virologic failure regardless of the baseline minority variant. However, the presence of baseline Y181C minority variant was associated with a higher probability of Y181C detection after virologic failure. NNRTI regimen choice and pre-existing NNRTI-resistant minority variants were both associated with the probability and type of resistance mutations detected after virologic failure.
Original languageEnglish
JournalThe Internet Journal of Infectious Diseases
ISSN1528-8366
DOIs
Publication statusPublished - 2012

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