Lars Jørgen Østergaard

Dialysis and renal transplantation in HIV-infected patients: a European survey

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Joan Carles Trullas, Unknown
  • Amanda Mocroft
  • ,
  • Federico Cofan, Unknown
  • Jérome Tourret, Unknown
  • Asunción Moreno, Unknown
  • Corinne Isnard Bagnis, Unknown
  • Christoph Andreas Fux, Unknown
  • Christine Katlama
  • ,
  • Peter Reiss
  • ,
  • Jens Lundgren
  • ,
  • Jose Maria Gatell, Unknown
  • Ole Kirk
  • ,
  • Jose M Miró
  • ,
  • EuroSIDA Investigators (Lars Østergaard, member)

OBJECTIVES: To determine prevalence and characteristics of end-stage renal diseases (ESRD) [dialysis and renal transplantation (RT)] among European HIV-infected patients.

METHODS: Cross-sectional multicenter survey of EuroSIDA clinics during 2008.

RESULTS: Prevalence of ESRD was 0.5%. Of 122 patients with ESRD 96 were on dialysis and 26 had received a RT. Median age was 47 years, 73% were males and 43% were black. Median duration of HIV infection was 11 years. Thirty-three percent had prior AIDS; 91% were receiving antiretrovirals; and 88% had undetectable viral load. Median CD4(+)T-cell count was 341 cells per cubic millimetre; 20.5% had hepatitis C coinfection. Most frequent causes of ESRD were HIV-associated nephropathy (46%) and other glomerulonephritis (28%). Hemodialysis (93%) was the most common dialysis modality; 34% of patients were on the RT waiting list. A poor HIV control was the reason for exclusion from RT waiting list in 22.4% of cases. All the RT recipients were all alive at the time of the survey. Acute rejection was reported in 8 patients (30%). Functioning graft was present in 21 (80%).

CONCLUSIONS: This is the first multinational cross-sectional study of ESRD among European HIV population. Low prevalence of ESRD was found. Two-thirds of patients were excluded from RT for non-HIV/AIDS-related pathologies. Most patients had a functioning graft despite a high acute rejection rate.

Original languageEnglish
JournalJournal of acquired immune deficiency syndromes (1999)
Volume55
Issue5
Pages (from-to)582-9
Number of pages8
DOIs
Publication statusPublished - 15 Dec 2010

    Research areas

  • Adult, CD4 Lymphocyte Count, Cross-Sectional Studies, Europe, Female, HIV Infections, Hepatitis Viruses, Hepatitis, Viral, Human, Humans, Kidney Failure, Chronic, Kidney Transplantation, Male, Middle Aged, Renal Dialysis

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