Lars Jørgen Østergaard

DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • R Olesen, Denmark
  • C Wejse
  • D R Velez, Denmark
  • C Bisseye, Denmark
  • M Sodemann, Denmark
  • P Aaby, Denmark
  • P Rabna, Denmark
  • A Worwui, Denmark
  • H Chapman, Denmark
  • M Diatta, Denmark
  • R A Adegbola, Denmark
  • P C Hill, Denmark
  • L Østergaard
  • S M Williams, Denmark
  • G Sirugo, Denmark
  • The Department of Infectious Diseases
We investigated the role of DC-SIGN (CD209), long pentraxin 3 (PTX3) and vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) in susceptibility to pulmonary tuberculosis (TB) in 321 TB cases and 347 healthy controls from Guinea-Bissau. Five additional, functionally relevant SNPs within toll-like receptors (TLRs) 2, 4 and 9 were typed but found, when polymorphic, not to affect host vulnerability to pulmonary TB. We did not replicate an association between SNPs in the DC-SIGN promoter and TB. However, we found that two polymorphisms, one in DC-SIGN and one in VDR, were associated in a nonadditive model with disease risk when analyzed in combination with ethnicity (P=0.03 for DC-SIGN and P=0.003 for VDR). In addition, PTX3 haplotype frequencies significantly differed in cases compared to controls and a protective effect was found in association with a specific haplotype (OR 0.78, 95% CI 0.63-0.98). Our findings support previous data showing that VDR SNPs modulate the risk for TB in West Africans and suggest that variation within DC-SIGN and PTX3 also affect the disease outcome.
Udgivelsesdato: 2007-Sep
Original languageEnglish
JournalGenes and Immunity
Pages (from-to)456-67
Number of pages11
Publication statusPublished - 2007

    Research areas

  • Adolescent, Adult, C-Reactive Protein, Case-Control Studies, Cell Adhesion Molecules, Female, Genetic Predisposition to Disease, Genotype, Guinea-Bissau, Haplotypes, Humans, Lectins, C-Type, Male, Mycobacterium tuberculosis, Polymorphism, Single Nucleotide, Receptors, Calcitriol, Receptors, Cell Surface, Serum Amyloid P-Component, Toll-Like Receptors, Tuberculosis, Pulmonary

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