Lars Henrik Fugger

Pathogenic CD8(+) T cells in multiple sclerosis

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  • The Department of Clinical Immunology
Traditionally, autoimmune pathogeneses have been attributed to CD4(+) T lymphocytes, as in multiple sclerosis (MS), rheumatoid arthritis, type 1 diabetes mellitus, and/or to B lymphocytes, as in myasthenia gravis and systemic lupus erythematosus. That is because their primary genetic associations are mostly with certain human leukocyte antigen class II alleles, whose gene products present antigens to CD4(+) T cells. Because few autoimmune diseases show stronger associations with major histocompatibility complex class I alleles (ankylosing spondylitis, Behçet's disease, and psoriasis), CD8(+) T cells, which interact with major histocompatibility complex class I molecules, have been largely ignored in autoimmunity research. However, a variety of findings has recently revived interest in this population, particularly in MS. First, it shows associations with major histocompatibility complex class I alleles. Second, its lesions show a predominance of CD8(+) T cells. Third, these represent effectors that can directly damage central nervous system target cells. Furthermore, several clinical trials of monoclonal antibodies specifically against CD4(+) T cells, or the polarizing cytokines on which they depend, have failed to show any therapeutic benefit in MS, unlike broader-spectrum antibodies that deplete all T cells. Here, we review the evidence that CD8(+) T cells play a role in MS pathogenesis.
Original languageEnglish
JournalAnnals of Neurology
Volume66
Issue2
Pages (from-to)132-41
Number of pages9
ISSN0364-5134
DOIs
Publication statusPublished - 2009

    Research areas

  • Alleles, Animals, Antibodies, Monoclonal, Brain, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Clinical Trials as Topic, Cytokines, Genes, MHC Class I, Humans, Models, Neurological, Multiple Sclerosis, Spinal Cord

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