Lars Henrik Fugger

Immunopathology of multiple sclerosis

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Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis point to distinct immunological pathways that drive disease relapses and progression. In light of this, we discuss our current understanding of multiple sclerosis immunopathology, evaluate long-standing hypotheses regarding the role of the immune system in the disease and delineate key questions that are still unanswered. Recent and anticipated advances in the field of immunology, and the increasing recognition of inflammation as an important component of neurodegeneration, are shaping our conceptualization of disease pathophysiology, and we explore the potential implications for improved healthcare provision to patients in the future.

Original languageEnglish
JournalNature Reviews. Immunology
Pages (from-to)545-58
Number of pages14
Publication statusPublished - 15 Sep 2015

    Research areas

  • Autoimmunity, Environmental Exposure, Genetic Predisposition to Disease, Humans, Inflammation, Multiple Sclerosis

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