Lars Henrik Fugger

Adaptive sugar sensors in hypothalamic feeding circuits.

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Brain glucose sensing is critical for healthy energy balance, but how appropriate neurocircuits encode both small changes and large background values of glucose levels is unknown. Here, we report several features of hypothalamic orexin neurons, cells essential for normal wakefulness and feeding: (i) A distinct group of orexin neurons exhibits only transient inhibitory responses to sustained rises in sugar levels; (ii) this sensing strategy involves time-dependent recovery from inhibition via adaptive closure of leak-like K(+) channels; (iii) combining transient and sustained glucosensing allows orexin cell firing to maintain sensitivity to small fluctuations in glucose levels while simultaneously encoding a large range of baseline glucose concentrations. These data provide insights into how vital behavioral orchestrators sense key features of the internal environment while sustaining a basic activity tone required for the stability of consciousness.
Original languageEnglish
JournalProceedings of the National Academy of Sciences of the United States of America
Pages (from-to)11975-80
Number of pages5
Publication statusPublished - 2008

    Research areas

  • Adaptation, Biological, Animals, Appetite Regulation, Electrophysiology, Glucose, Hypothalamus, Intracellular Signaling Peptides and Proteins, Mice, Mice, Transgenic, Neurons, Neuropeptides

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