Lars Henrik Fugger

A molecule basis for the HLA association in rheumatoid arthritis

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

Rheumatoid arthritis (RA) is a common chronic autoimmune disease that primarily affects the joints. The etiology of RA is unknown, and the pathogenesis is only poorly defined. One of the few clues to the understanding of the pathogenesis of RA is the observation that the disease is associated with genes in the major histocompatibility complex (MHC). Recent structural and functional studies provide molecular insight into the role of MHC genes in RA susceptibility. This insight provides an important basis for further understanding of the disease mechanism, generation of humanized animal models for RA, and the development of new immunomodulatory drugs with a minimum of unwanted side effects.
Original languageEnglish
JournalReviews in Immunogenetics
Volume2
Issue1
Pages (from-to)81-7
Number of pages7
ISSN1398-1714
Publication statusPublished - 2000

    Research areas

  • Animals, Arthritis, Rheumatoid, Autoantigens, Disease Models, Animal, Epitopes, T-Lymphocyte, HLA Antigens, Humans

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