Lars Henrik Fugger

  1. Journal article › Research › Not peer-reviewed
  2. Published

    A functional and structural basis for T cell receptor crossreactivity in multiple sclerosis. / Lang, H.; Jacobsen, H.; Ikemizu, S.; Andersson, C.; Harlos, K.; Madsen, L.; Hjorth, P.; Søndergaard, L.; Svejgaard, A.; Wucherpfennig, K.; Stuart, D.I.; Bell, J.I.; Jones, E.Y.; Fugger, L.

    In: Nature Immunology, Vol. 3, 2002, p. 940-943.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  3. Published

    A molecular basis for the HLA association in rheumatoid arthritis. / Andersson, E.C.; Svendsen, Pia; Svejgaard, A.; Holmdahl, R.and; Fugger, L.

    In: Reviews in Immunogenetics, Vol. 2, 2000, p. 81-87.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  4. Published

    A molecule basis for the HLA association in rheumatoid arthritis. / Andersson, E C; Svendsen, P; Svejgaard, Arne; Holmdahl, R; Fugger, L; Svendsen, Pia.

    In: Reviews in Immunogenetics, Vol. 2, No. 1, 2000, p. 81-7.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  5. Published

    A role for tandem-pore K+ channels in hypothalamic sensing of glucose. / Burdakov, D.; Jensen, Lise Torp; Alexopoulos, H.; Gerasimenko, O.; Fugger, Lars Henrik; Verkhratsky, A.

    In: Neuron, Vol. 50, 2006, p. 711-722.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  6. Published

    Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. / Friese, MA; Cramer, MJ; Etzensperger, R; Vergo, S; Wemmie, JA; Welsh, MJ; Vincent, A; Fugger, Lars Henrik.

    In: Nat. Med, Vol. 13, No. 12, 2007, p. 1483-1489.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  7. Published

    Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy? / Friese, M. A.; Fugger, Lars Henrik.

    In: Brain, Vol. 128, 2005, p. 1747-63.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  8. Published

    Characterization of myelin oligodendrocyte glycoprotein epitopes presented by astrocytes from HLA-DR2 and HLA-DR4-transgenic mice. / Kort, J. J.; Fugger, Lars Henrik; Weissert, R.; Forsthuber, T. G.

    In: J. Neuroimmunology, Vol. 173, 2006, p. 23-34.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  9. Published

    Collagen specific Th cells with proinflammatory capacities are detectable only very early in the disease course of callogen induced arthritis. / Svendsen, Pia; Andersen, C.B.; Willcox, N.; Coyle, A.J.; Holmdahl, R.; Kamradt, T.; Fugger, L.

    In: J. Immunol., Vol. 173, 2004, p. 7037-7045.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  10. Published

    Conflicting selective forces affect CD8+ T-cell receptor contact sites in an HLA-A2-immunodominant HIV epitope. / Fugger, Astrid Iversen; Stewart-Jones, G.; Learn, G. H.; Christie, N.; Sylvester-Hviid, C.; Armitage, A. E.; Kaul, R.; Beattie, T.; Lee, J. K.; Li, Y.; Chotiyarnwong, P.; Dong, T.; Xu, X.; Luscher, M. A.; MacDonald, K.; Ullum, H.; Klarund-Pedersen, B.; Skinhøj, P.; Fugger, Lars Henrik; Buus, S.; Mullins, J. I.; Jones, E. Y.; van der Merwe, P. A.; McMichael, A. J.

    In: Nature, Vol. 7, 2006, p. 179-189.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  11. Published

    Control of autoimmunity by "epitope theft" / Kranc, K. R.; Taylor, A. M.; Wilcox, N.; Fugger, Lars Henrik.

    In: Trends. Mol. Med., Vol. 11, No. 1, 2005, p. 1-4.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  12. Published

    Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy. / Siebold, C.; Hansen, B.E.; Wyer, J.R.; Harlos, K.; Esnouf, R.; Svejgaard, A.; Bell, J.I.; Strominger, J.L.; Jones, E.Y; Fugger, L.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, 2004, p. 166-42.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  13. Published

    Deficiency of mannan-binding lectin-associated serine protease-2 (MASP-2) in a patient with a history of infections and immunological disease. / Stengaard-Pedersen, K.; Thiel, S.; Jensen, L.T.; Sjöholm, A.G.; Fugger, L.; Jensenius, J.C.

    In: N. Engl. J. Med., Vol. 349, 2003, p. 554-560.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  14. Published

    Destructive processing by asparagine endopeptidase limits the level of presentation of a dominant T cell epitope in myelin basic protein. / Manoury, B.; Mazzeo, D.; Fugger, L.; Viner, N.; Ponsford, M.; Streeter, H.; Mazza, G.; Wraith, D.C.; Watts, C.

    In: Nature Immunology, Vol. 2, 2002, p. 169-174.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  15. Published

    Efficient purification of unique antibodies using peptide columns. / Brix Jensen, L.; Riise, E.; Nielsen, L.K.; Dziegiel, M.; Fugger, L.; Engberg, J.

    In: J Immunological Methods, Vol. 284, 2004, p. 45-54.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  16. Published

    HLA-DR4 and rheumatoid arthritis. Studies in mice and men. / Fugger, Lars Henrik; Svejgaard, A.

    In: Arthritis research & therapy, Vol. 2, 2000, p. 208-211.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  17. Published

    Human autoimmunity genes in mice. / Fugger, L.

    In: Current Opinion in Immunology, Vol. 12, 2000, p. 698-703.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  18. Published

    Humanized animal models for autoimmune diseases. / Gregersen, Jon Waarst; Holmes, S.; Fugger, L.

    In: HLA, Vol. 63, 2004, p. 383-394.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  19. Published

    Humanized mouse models for organ-specific autoimmune diseases. / Friese, M.A.; Jensen, Lise Torp; Fugger, Lars Henrik.

    In: Curr Opinion Immunol, Vol. 18, No. 6, 2006, p. 704-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  20. Published

    Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. / Tzartos, JS; Friese, MA; Craner, MJ; Palace, J; Newcombe, J; Esiri, MM; Fugger, Lars Henrik.

    In: American Journal of Pathology, Vol. 172, No. 1, 2008, p. 146-155.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  21. Published

    Joint-specific and systemic autoreactivity in the development of inflammatory arthritis. / Fugger, L.

    In: Arthritis research & therapy, Vol. 2, 2000, p. 2-4.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  22. Published

    Linkage analysis of a candidate region in Scandinavian sib pairs with multiple sclerosis reveals linkage to chromosomes 17q. / Larsen, F.; Oturai, A.; Ryder, L.P.; Madsen, H.O.; Hillert, J.; Fredrikson, S.; Sandberg-Wolheim, M.; Laaksonen, M.; Harboe, H.; Sawcer, S.; Fugger, L.; Sørensen, P.S.and; Svejgaard, A.

    In: Genes and Immunity, Vol. 1, 2000, p. 456-459.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  23. Published

    MHC II molecules in inflammatory diseases: interplay of qualitities and quantities. / Friese, M.A.; Jones, E.Y.; Fugger, Lars Henrik.

    In: Trends Immunol., Vol. 26, No. 11, 2005, p. 559-61.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  24. Published

    MHC class II proteins and disease: a structural perspective. / Jones, E. Y.; Fugger, Lars Henrik; Strominger, J. L.; Siebold, C.

    In: Nat Rev Immunol, Vol. 6, No. 4, 2006, p. 271-282.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  25. Published

    Modeling the interactions of a peptide-major histocompatibility class I ligand with its receptors. I. Recognition by two alpha beta T cell receptors. / Rognan, D.; Stryhn, A.; Fugger, L.; Lyngbæk, S.; Engberg, J.; and, Andersen.P.S.; Buus, S.

    In: J Comput Aided Mol Des, Vol. 14, 2000, p. 53-69.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  26. Published

    Multiple crossreactive self-ligands for Borrelia burgdoferi-specific HLA-DR4 restricted T cells. / Maier, B.; Molinger, M.; Cope, A.P.; Fugger, L.; Schneider-Mergener, J.; Sønderstrup, G.; Kamradt, T.; Kramer, A.

    In: European J. Immunol, Vol. 30, 2000, p. 448-457.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  27. Published

    Multiple sclerosis: MHC associataions and therapeutic implications. / Holmes, S.; Siebold, C.; Jones, E. Y.; Friese, M. A.; Fugger, Lars Henrik; Bell, J.

    In: Expert Rev Mol Med, Vol. 7, No. 3, 2005, p. 1-17.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  28. Published

    Myelin oligodendrocyte glycoprotein-35-55 peptide, but not myelin basic protein-87-99 peptide, induces severe chronic experimental autoimmune encephalomyelititis in HLA-DR2 transgenic mice. / Rich, C.; Zamora, A.; Jacobsen, H.; Offner, H.; Jones, R.; Fugger, L.; Vandenbark, A.A.

    In: Eur. J. Immunol., Vol. 34, 2004, p. 1251-1261.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  29. Published

    Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis. / Fridkis-Hareli, M.; Santambrogio, L.; Stern, J.N.; Fugger, L.; Brosnan, C.; Strominger, J.L.

    In: The Journal of Clinical Investigation, Vol. 109, 2002, p. 1635-1643.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  30. Published

    Peptides spanning the junctional region of both the abl/bcr and the bcr/abl fusion protiens bind common HLA class I molecules. / Berke, Z.; Andersen, M.H.; Pedersen, M.; Fugger, L.; Zeuthen, J.and; Haurum, J.S.

    In: Leukemia, Vol. 14, 2000, p. 419-426.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  31. Published

    Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis. / Bäcklund, J.; Carlsen, J.; Höger, T.; Holm, B.; Fugger, L.; Kihlberg, J.; Burkhardt, H.; Holmdahl, R.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, 2002, p. 9960-9965.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  32. Published

    Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice. / Vandenbark, A.A.; Rich, C.; Mooney, J.; Zamora, A.; Wang, C.; Huan, J.; Fugger, L.; Offner, H.; Jones, R.; Burrows, G.G.

    In: J. Immunol., Vol. 171, 2003, p. 127-133.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  33. Published

    Synthetic peptides that inhibit binding of the collagen type II 261-273 epitope rheumatoid arthritis-associated HLA-DR1 and -DR4 molecules and collagen-specific T-cell responses. / Fridkis-Hareli, M.; Rosloniec, E.F.; Fugger, L.; Strominger, J.L.

    In: Human Immunology, Vol. 61, 2000, p. 640-650.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  34. Published

    Synthetic peptides that inhibit binding of the myelin basic protein 85-99 epitope to multiple sclerosis-associated HLA-DR2 molecules and MBP-specific T-cell responses. / Fridkis-Hareli, M.; Stern, J.N.; Fugger, Lars Henrik; Strominger, J.L.

    In: Human Immunology, Vol. 62, 2001, p. 753-763.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  35. Published

    T cells and microglia as drivers of multiple sclerosis pathology. / Friese, M A; Fugger, Lars Henrik.

    In: Brain, Vol. 130, 2007, p. 2755-2757.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  36. Published

    The nature of molecular recognition by T cells. / Davis, S.J.; Ikemizu, S.; Evans, E.J.; Fugger, L.; Bakker, T.R.; Merwe van der, P.

    In: Nature Immunology, Vol. 4, 2003, p. 217-224.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  37. Published

    The value of animal models for drug development in multiple sclerosis. / Friese, M.; Montalban, X.; John, I.; Bell, J. I.; Martin, R.; Fugger, Lars Henrik.

    In: Brain, Vol. 129, 2006, p. 1940-1952.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  38. Published

    Therapeutic vaccination against active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules. / Dzhambazov, B.; Nandakumar, K. S.; Kihlberg, J.; Fugger, Lars Henrik; Holmdahl, R.; Vestberg, M.

    In: Journal of Imunology, Vol. 1, 2006, p. 1525-1533.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  39. Published

    Tracking of proinflammatory collagen-specific T cells in early and late collagen-induced arthritis in humanized mice. / Svendsen, Pia; Andersen, Claus B; Willcox, Nick; Coyle, Anthony J; Holmdahl, Rikard; Kamradt, Thomas; Fugger, Lars; Svendsen, Pia.

    In: Journal of Immunology, Vol. 173, No. 11, 01.12.2004, p. 7037-45.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  40. Published

    Visualization of myelin basic protein T-cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the HLA-DR2-MBP 85-89 complex. / Krogsgaard, M.; Wucherpfennig, K.W.; Hansen, B.E.; Svejgaard, A.; Pyrdol, J.; Canella, B.; Cedric Raine, C.; Engberg, J.and; Fugger, L.

    In: J. Exp. Med., Vol. 191, 2000, p. 1395-1412.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  41. Journal article › Research › Peer-reviewed
  42. Published

    A clinical conundrum : the detrimental effect of TNF antagonists in multiple sclerosis. / Dendrou, Calliope A; Bell, John I; Fugger, Lars.

    In: Pharmacogenomics, Vol. 14, No. 12, 09.2013, p. 1397-404.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  43. Published

    A functional and structural basis for TCR cross-reactivity in multiple sclerosis. / Lang, H.L.E.; Jacobsen, H.; Ikemizy, S.; Anderson, C.; Harlos, K.; Madsen, L.; Hjorth, Jens Peter; Søndergaard, L.; Svejgaard, A.; Wucherpfennig, K.; Stuart, D.I.; Bell, J.I.; Jones, E.Y.; Fugger, Lars Henrik.

    In: Nature Immunology, Vol. 3, 2002, p. 940-943.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  44. Published

    A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. / Faergeman, Soren L.; Evans, Hayley; Attfield, Kathrine E.; Desel, Christiane; Kuttikkatte, Subita Balaram; Sommerlund, Mette; Jensen, Lise Torp; Frokiaer, Jorgen; Friese, Manuel A.; Matthews, Paul M.; Luchtenborg, Christian; Brügger, Britta; Oturai, Annette Bang; Dendrou, Calliope A.; Fugger, Lars.

    In: Cell Death and Disease, Vol. 11, 303, 05.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  45. Published

    A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity. / Ooi, Joshua D; Jiang, Jhih-Hang; Eggenhuizen, Peter J; Chua, Ling L; van Timmeren, Mirjan; Loh, Khai L; O'Sullivan, Kim M; Gan, Poh Y; Zhong, Yong; Tsyganov, Kirill; Shochet, Lani R; Ryan, Jessica; Stegeman, Coen A; Fugger, Lars; Reid, Hugh H; Rossjohn, Jamie; Heeringa, Peter; Holdsworth, Stephen R; Peleg, Anton Y; Kitching, A Richard.

    In: Nature Communications, Vol. 10, No. 1, 3392, 2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  46. Published

    APOBEC3G-induced hypermutation of human immunodeficiency virus type-1 is typically a discrete "all or nothing" phenomenon. / Armitage, Andrew E; Deforche, Koen; Chang, Chih-Hao; Wee, Edmund; Kramer, Beatrice; Welch, John J; Gerstoft, Jan; Fugger, Lars; McMichael, Andrew; Rambaut, Andrew; Iversen, Astrid K N.

    In: PLoS genetics, Vol. 8, No. 3, 2012, p. e1002550.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  47. Published

    Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model. / Vergo, Sandra; Craner, Matthew J; Etzensperger, Ruth; Attfield, Kathrine; Friese, Manuel A; Newcombe, Jia; Esiri, Margaret; Fugger, Lars.

    In: Brain, Vol. 134, No. Pt 2, 01.02.2011, p. 571-84.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  48. Published

    Activation of central orexin/hypocretin neurons by dietary amino acids. / Karnani, Mahesh M; Apergis-Schoute, John; Adamantidis, Antoine; Jensen, Lise T; de Lecea, Luis; Fugger, Lars; Burdakov, Denis.

    In: Sensory Neuron, Vol. 72, No. 4, 2011, p. 616-29.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  49. Published

    Adaptive sugar sensors in hypothalamic feeding circuits. / Williams, Rhiannan H; Alexopoulos, Haris; Jensen, Lise T; Fugger, Lars; Burdakov, Denis.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 33, 2008, p. 11975-80.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  50. Published

    Amiloride Clinical Trial In Optic Neuritis (ACTION) protocol : a randomised, double blind, placebo controlled trial. / McKee, Justin B; Elston, John; Evangelou, Nikos; Gerry, Stephen; Fugger, Lars; Kennard, Christopher; Kong, Yazhuo; Palace, Jacqueline; Craner, Matthew.

    In: BMJ Open, Vol. 5, No. 11, 2015, p. e009200.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  51. Published

    An alternative conformation of the T-cell receptor beta constant region. / van Boxel, Gijs I; Holmes, Samantha; Fugger, Lars; Jones, E Yvonne.

    In: Journal of Molecular Biology, Vol. 400, No. 4, 2010, p. 828-37.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  52. Published

    Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination. / Grodeland, Gunnveig; Fredriksen, Agnete Brunsvik; Løset, Geir Åge; Vikse, Elisabeth; Fugger, Lars; Bogen, Bjarne.

    In: Journal of Immunology, Vol. 197, No. 9, 01.11.2016, p. 3575-3585.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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