Lars Henrik Fugger

  1. 2020
  2. Published

    Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases. / Fugger, Lars; Jensen, Lise Torp; Rossjohn, Jamie.

    In: Cell, Vol. 181, No. 1, 04.2020, p. 63-80.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  3. Published

    B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2. / du Pré, M Fleur; Blazevski, Jana; Dewan, Alisa E; Stamnaes, Jorunn; Kanduri, Chakravarthi; Sandve, Geir Kjetil; Johannesen, Marie K; Lindstad, Christian B; Hnida, Kathrin; Fugger, Lars; Melino, Gerry; Qiao, Shuo-Wang; Sollid, Ludvig M.

    In: The Journal of Experimental Medicine, Vol. 217, No. 2, e20190860, 03.02.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. Published

    Inflammation-related plasma and CSF biomarkers for multiple sclerosis. / Huang, Jesse; Khademi, Mohsen; Fugger, Lars; Lindhe, Örjan; Novakova, Lenka; Axelsson, Markus; Malmeström, Clas; Constantinescu, Clara; Lycke, Jan; Piehl, Fredrik; Olsson, Tomas; Kockum, Ingrid.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 23, 09.06.2020, p. 12952-12960.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. Published

    A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. / Faergeman, Soren L.; Evans, Hayley; Attfield, Kathrine E.; Desel, Christiane; Kuttikkatte, Subita Balaram; Sommerlund, Mette; Jensen, Lise Torp; Frokiaer, Jorgen; Friese, Manuel A.; Matthews, Paul M.; Luchtenborg, Christian; Brügger, Britta; Oturai, Annette Bang; Dendrou, Calliope A.; Fugger, Lars.

    In: Cell Death and Disease, Vol. 11, 303, 05.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. Published

    Identifying cross-disease components of genetic risk across hospital data in the UK Biobank. / Cortes, Adrian; Albers, Patrick K; Dendrou, Calliope A; Fugger, Lars; McVean, Gil.

    In: Nature Genetics, Vol. 52, No. 1, 12.2020, p. 126-134.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. Published

    Recovery from COVID-19 in a B-cell-depleted multiple sclerosis patient. / Attfield, Kate; Iversen, Astrid Kn; Gold, Ralf; Fugger, Lars; Haghikia, Aiden.

    In: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 26, No. 10, 09.2020, p. 1261-1264.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. 2019
  9. Published

    A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity. / Ooi, Joshua D; Jiang, Jhih-Hang; Eggenhuizen, Peter J; Chua, Ling L; van Timmeren, Mirjan; Loh, Khai L; O'Sullivan, Kim M; Gan, Poh Y; Zhong, Yong; Tsyganov, Kirill; Shochet, Lani R; Ryan, Jessica; Stegeman, Coen A; Fugger, Lars; Reid, Hugh H; Rossjohn, Jamie; Heeringa, Peter; Holdsworth, Stephen R; Peleg, Anton Y; Kitching, A Richard.

    In: Nature Communications, Vol. 10, No. 1, 3392, 2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. 2018
  11. Published

    HLA variation and disease. / Dendrou, Calliope A; Petersen, Jan; Rossjohn, Jamie; Fugger, Lars.

    In: Nature Reviews. Immunology, Vol. 18, No. 5, 05.2018, p. 325-339.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  12. 2017
  13. Published

    Immunomodulation in multiple sclerosis : promises and pitfalls. / Dendrou, Calliope A; Fugger, Lars.

    In: Current Opinion in Immunology, Vol. 49, 2017, p. 37-43.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  14. Published

    Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells. / Ooi, Joshua D; Petersen, Jan; Tan, Yu H; Huynh, Megan; Willett, Zoe J; Ramarathinam, Sri H; Eggenhuizen, Peter J; Loh, Khai L; Watson, Katherine A; Gan, Poh Y; Alikhan, Maliha A; Dudek, Nadine L; Handel, Andreas; Hudson, Billy G; Fugger, Lars; Power, David A; Holt, Stephen G; Coates, P Toby; Gregersen, Jon W; Purcell, Anthony W; Holdsworth, Stephen R; La Gruta, Nicole L; Reid, Hugh H; Rossjohn, Jamie; Kitching, A Richard.

    In: Nature, Vol. 545, No. 7653, 11.05.2017, p. 243-247.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. Published

    Structural and regulatory diversity shape HLA-C protein expression levels. / Kaur, Gurman; Gras, Stephanie; Mobbs, Jesse I; Vivian, Julian P; Cortes, Adrian; Barber, Thomas; Kuttikkatte, Subita Balaram; Jensen, Lise Torp; Attfield, Kathrine E; Dendrou, Calliope A; Carrington, Mary; McVean, Gil; Purcell, Anthony W; Rossjohn, Jamie; Fugger, Lars.

    In: Nature Communications, Vol. 8, 26.06.2017, p. 15924.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published

    Severe B-cell-mediated CNS disease secondary to alemtuzumab therapy. / Haghikia, Aiden; Dendrou, Calliope A; Schneider, Ruth; Grüter, Thomas; Postert, Thomas; Matzke, Mike; Stephanik, Heike; Fugger, Lars; Gold, Ralf.

    In: Lancet Neurology, Vol. 16, No. 2, 02.2017, p. 104-106.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. Published

    Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank. / Cortes, Adrian; Dendrou, Calliope A; Motyer, Allan; Jostins, Luke; Vukcevic, Damjan; Dilthey, Alexander; Donnelly, Peter; Leslie, Stephen; Fugger, Lars; McVean, Gil.

    In: Nature Genetics, Vol. 49, No. 9, 09.2017, p. 1311-1318.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. 2016
  19. Published

    Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions. / Jönsson, Peter; Southcombe, Jennifer H; Santos, Ana Mafalda; Huo, Jiandong; Fernandes, Ricardo A; McColl, James; Lever, Melissa; Evans, Edward J; Hudson, Alexander; Chang, Veronica T; Hanke, Tomáš; Godkin, Andrew; Dunne, Paul D; Horrocks, Mathew H; Palayret, Matthieu; Screaton, Gavin R; Petersen, Jan; Rossjohn, Jamie; Fugger, Lars; Dushek, Omer; Xu, Xiao-Ning; Davis, Simon J; Klenerman, David.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 20, 17.05.2016, p. 5682-7.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. Published

    Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination. / Grodeland, Gunnveig; Fredriksen, Agnete Brunsvik; Løset, Geir Åge; Vikse, Elisabeth; Fugger, Lars; Bogen, Bjarne.

    In: Journal of Immunology, Vol. 197, No. 9, 01.11.2016, p. 3575-3585.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. Published

    Inhibitory Interplay between Orexin Neurons and Eating. / González, J Antonio; Jensen, Lise T; Iordanidou, Panagiota; Strom, Molly; Fugger, Lars; Burdakov, Denis.

    In: Current Biology, Vol. 26, No. 18, 26.09.2016, p. 2486-91.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. Published

    Neuroinflammation - using big data to inform clinical practice. / Dendrou, Calliope A; McVean, Gil; Fugger, Lars.

    In: Nature Reviews. Neurology, Vol. 12, No. 12, 12.2016, p. 685-698.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. / Dendrou, Calliope A; Cortes, Adrian; Shipman, Lydia; Evans, Hayley G; Attfield, Kathrine E; Jostins, Luke; Barber, Thomas; Kaur, Gurman; Kuttikkatte, Subita Balaram; Leach, Oliver A; Desel, Christiane; Faergeman, Soren L; Cheeseman, Jane; Neville, Matt J; Sawcer, Stephen; Compston, Alastair; Johnson, Adam R; Everett, Christine; Bell, John I; Karpe, Fredrik; Ultsch, Mark; Eigenbrot, Charles; McVean, Gil; Fugger, Lars.

    In: Science Translational Medicine, Vol. 8, No. 363, 02.11.2016, p. 363ra149.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. 2015
  25. Published

    Factors influencing success of clinical genome sequencing across a broad spectrum of disorders. / Taylor, Jenny C; Martin, Hilary C; Lise, Stefano; Broxholme, John; Cazier, Jean-Baptiste; Rimmer, Andy; Kanapin, Alexander; Lunter, Gerton; Fiddy, Simon; Allan, Chris; Aricescu, A Radu; Attar, Moustafa; Babbs, Christian; Becq, Jennifer; Beeson, David; Bento, Celeste; Bignell, Patricia; Blair, Edward; Buckle, Veronica J; Bull, Katherine; Cais, Ondrej; Cario, Holger; Chapel, Helen; Copley, Richard R; Cornall, Richard; Craft, Jude; Dahan, Karin; Davenport, Emma E; Dendrou, Calliope; Devuyst, Olivier; Fenwick, Aimée L; Flint, Jonathan; Fugger, Lars; Gilbert, Rodney D; Goriely, Anne; Green, Angie; Greger, Ingo H; Grocock, Russell; Gruszczyk, Anja V; Hastings, Robert; Hatton, Edouard; Higgs, Doug; Hill, Adrian; Holmes, Chris; Howard, Malcolm; Hughes, Linda; Humburg, Peter; Johnson, David; Karpe, Fredrik; Kingsbury, Zoya; Kini, Usha; Knight, Julian C; Krohn, Jonathan; Lamble, Sarah; Langman, Craig; Lonie, Lorne; Luck, Joshua; McCarthy, Davis; McGowan, Simon J; McMullin, Mary Frances; Miller, Kerry A; Murray, Lisa; Németh, Andrea H; Nesbit, M Andrew; Nutt, David; Ormondroyd, Elizabeth; Oturai, Annette Bang; Pagnamenta, Alistair; Patel, Smita Y; Percy, Melanie; Petousi, Nayia; Piazza, Paolo; Piret, Sian E; Polanco-Echeverry, Guadalupe; Popitsch, Niko; Powrie, Fiona; Pugh, Chris; Quek, Lynn; Robbins, Peter A; Robson, Kathryn; Russo, Alexandra; Sahgal, Natasha; van Schouwenburg, Pauline A; Schuh, Anna; Silverman, Earl; Simmons, Alison; Sørensen, Per Soelberg; Sweeney, Elizabeth; Taylor, John; Thakker, Rajesh V; Tomlinson, Ian; Trebes, Amy; Twigg, Stephen R F; Uhlig, Holm H; Vyas, Paresh; Vyse, Tim; Wall, Steven A; Watkins, Hugh; Whyte, Michael P; Witty, Lorna; Wright, Ben; Yau, Chris; Buck, David; Humphray, Sean; Ratcliffe, Peter J; Bell, John I; Wilkie, Andrew O M; Bentley, David; Donnelly, Peter; McVean, Gilean.

    In: Nature Genetics, Vol. 47, No. 7, 07.2015, p. 717-26.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. Published

    Amiloride Clinical Trial In Optic Neuritis (ACTION) protocol : a randomised, double blind, placebo controlled trial. / McKee, Justin B; Elston, John; Evangelou, Nikos; Gerry, Stephen; Fugger, Lars; Kennard, Christopher; Kong, Yazhuo; Palace, Jacqueline; Craner, Matthew.

    In: BMJ Open, Vol. 5, No. 11, 2015, p. e009200.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. Published

    Immunopathology of multiple sclerosis. / Dendrou, Calliope A; Fugger, Lars; Friese, Manuel A.

    In: Nature Reviews. Immunology, Vol. 15, No. 9, 15.09.2015, p. 545-58.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  28. 2014
  29. Published

    HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. / Tenzer, Stefan; Crawford, Hayley; Pymm, Phillip; Gifford, Robert; Sreenu, Vattipally B; Weimershaus, Mirjana; de Oliveira, Tulio; Burgevin, Anne; Gerstoft, Jan; Akkad, Nadja; Lunn, Daniel; Fugger, Lars; Bell, John; Schild, Hansjörg; van Endert, Peter; Iversen, Astrid K N.

    In: Cell Reports, Vol. 7, No. 2, 24.04.2014, p. 448-63.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  30. Published

    Multiple sclerosis : Insights into pathophysiology and novel therapeutic avenues. / Gold, Ralf; Fugger, Lars.

    In: Experimental Neurology, 18.04.2014.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  31. Published

    Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis. / Friese, Manuel A; Schattling, Benjamin; Fugger, Lars.

    In: Nature Reviews. Neurology, Vol. 10, No. 4, 04.2014, p. 225-38.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  32. Published

    Please mind the gap : axonal transport deficits in multiple sclerosis neurodegeneration. / Dendrou, Calliope A; Fugger, Lars.

    In: Neuron, Vol. 84, No. 6, 17.12.2014, p. 1105-7.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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