Lars Bolund

Toward the massive genome of Proteus anguinus-illuminating longevity, regeneration, convergent evolution, and metabolic disorders

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review


  • Rok Kostanjšek, University of Ljubljana
  • ,
  • Børge Diderichsen, Aarhus University
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  • Hans Recknagel, University of Ljubljana
  • ,
  • Nina Gunde-Cimerman, University of Ljubljana
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  • Cene Gostinčar, University of Ljubljana, Lars Bolund Institute of Regenerative Medicine
  • ,
  • Guangyi Fan, Lars Bolund Institute of Regenerative Medicine
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  • Dušan Kordiš, Jožef Stefan Institute
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  • Peter Trontelj, University of Ljubljana
  • ,
  • Hui Jiang, BGI-Shenzhen, China
  • Lars Bolund
  • Yonglun Luo

Deciphering the genetic code of organisms with unusual phenotypes can help answer fundamental biological questions and provide insight into mechanisms relevant to human biomedical research. The cave salamander Proteus anguinus (Urodela: Proteidae), also known as the olm, is an example of a species with unique morphological and physiological adaptations to its subterranean environment, including regenerative abilities, resistance to prolonged starvation, and a life span of more than 100 years. However, the structure and sequence of the olm genome is still largely unknown owing to its enormous size, estimated at nearly 50 gigabases. An international Proteus Genome Research Consortium has been formed to decipher the olm genome. This perspective provides the scientific and biomedical rationale for exploring the olm genome and outlines potential outcomes, challenges, and methodological approaches required to analyze and annotate the genome of this unique amphibian.

Original languageEnglish
JournalAnnals of the New York Academy of Sciences
Pages (from-to)5-11
Number of pages7
Publication statusPublished - Jan 2022

    Research areas

  • CAVEFISH, DNA, MODEL, biomedical application, conservation genomics, large genome sequencing, olm, subterranean environment

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