Lars Bolund

Interaction between FOXO1A-209 Genotype and Tea Drinking is Significantly Associated with Reduced Mortality at Advanced Ages

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review


  • Yi Zeng
  • ,
  • Huashuai Chen
  • ,
  • Ting Ni
  • ,
  • Rongping Ruan
  • ,
  • Chao Nie
  • ,
  • Xiaomin Liu, Denmark
  • Lei Feng
  • ,
  • Fengyu Zhang
  • ,
  • Jiehua Lu, Denmark
  • Jianxin Li, Denmark
  • Yang Li
  • ,
  • Wei Tao
  • ,
  • William Gottschalk, Denmark
  • Mike Lutz, Denmark
  • Kenneth Land
  • ,
  • Anatoli I Yashin, Denmark
  • Qihua Tan
  • ,
  • Ze Yang
  • ,
  • Lars Bolund
  • Ming Qi, Denmark
  • Huanming Yang
  • ,
  • Junxia Min, Denmark
  • Craig D Willcox
  • ,
  • Bradley Willcox
  • ,
  • Jun Gu
  • ,
  • Elizabeth Hauser
  • ,
  • Xiao-Li Tian
  • ,
  • James W Vaupel

Based on the genotypic/phenotypic data from Chinese Longitudinal Healthy Longevity Survey (CLHLS) and Cox proportional hazard model, the present study demonstrates that interactions between carrying FOXO1A-209 genotypes and tea drinking are significantly associated with lower risk of mortality at advanced ages. Such significant association is replicated in two independent Han Chinese CLHLS cohorts (p =0.028-0.048 in the discovery and replication cohorts, and p =0.003-0.016 in the combined dataset). We found the associations between tea drinking and reduced mortality are much stronger among carriers of the FOXO1A-209 genotype compared to non-carriers, and drinking tea is associated with a reversal of the negative effects of carrying FOXO1A-209 minor alleles, that is, from a substantially increased mortality risk to substantially reduced mortality risk at advanced ages. The impacts are considerably stronger among those who carry 2 copies of the FOXO1A minor allele than those who carry 1 copy. Based on previously reported experiments on human cell models concerning FOXO1A-by-tea-compounds interactions, we speculate that results in the present study indicate that tea drinking may inhibit FOXO1A-209 gene expression and its biological functions, which reduces the negative impacts of FOXO1A-209 gene on longevity (as reported in the literature) and offers protection against mortality risk at oldest-old ages. Our empirical findings imply that the health outcomes of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles, and the research on the effects of nutrigenomics interactions could potentially be useful for rejuvenation therapies in the clinic or associated healthy aging intervention programs.

Original languageEnglish
JournalRejuvenation Research
Pages (from-to)195-203
Number of pages9
Publication statusPublished - 2016

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