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Lars Bolund

GxE Interactions Between FOXO Genotypes and Tea Drinking Significantly Affect Cognitive Disability at Advanced Ages in China

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DOI

  • Yi Zeng, Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, North Carolina. Center for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing, China., Denmark
  • Huashuai Chen, Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, North Carolina. Business School of Xiangtan University, Hunan, China., Denmark
  • Ting Ni, State Key Laboratory of Genetics Engineering & MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China., Denmark
  • Rongping Ruan, Renmin University of China, Beijing, China., Denmark
  • Lei Feng, National University of Singapore, Denmark
  • Chao Nie, BGI-Shenzhen, Denmark
  • Lingguo Cheng, School of Business, Nanjing University, China., Denmark
  • Yang Li, Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China., Denmark
  • Wei Tao, Peking University
    • ,
  • Jun Gu, Peking University, Denmark
  • Kenneth C Land, Population Research Institute, Duke University, Durham, North Carolina., Denmark
  • Anatoli Yashin, Population Research Institute, Duke University, Durham, North Carolina.
    • ,
  • Qihua Tan, University of Southern Denmark
    • ,
  • Ze Yang, National Institute of Geriatrics, Beijing Hospital, Ministry of Health of China, Beijing, China., Denmark
  • Lars Bolund
  • Huanming Yang, BGI-Shenzhen, China. James D. Watson Institute of Genome Sciences, Hangzhou, China. Princess Al-Jawhara Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
    • ,
  • Elizabeth Hauser, Center for Human Genetics, Medical Center, Duke University, Durham, North Carolina., Denmark
  • Craig D Willcox, Public Health and Gerontology, Department of Human Welfare, Okinawa International University, Ginowan, Japan., Denmark
  • Bradley J Willcox, Department of Research, Kuakini Medical Center and Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu., Denmark
  • Xiao-Li Tian, Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China., Denmark
  • James W Vaupel, Max Planck Institute for Demographic Research, Rostock, Germany.

Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+ demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292 and tea drinking at around age 60 or at present time were significantly associated with lower risk of cognitive disability at advanced ages. Associations between tea drinking and reduced cognitive disability were much stronger among carriers of the genotypes of FOXO1A-266 or FOXO3-310 or FOXO3-292 compared with noncarriers, and it was reconfirmed by analysis of three-way interactions across FOXO genotypes, tea drinking at around age 60, and at present time. Based on prior findings from animal and human cell models, we postulate that intake of tea compounds may activate FOXO gene expression, which in turn may positively affect cognitive function in the oldest old population. Our empirical findings imply that the health benefits of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles.

Original languageEnglish
JournalJournals of Gerontology. Series A: Biological Sciences & Medical Sciences
ISSN1079-5006
DOIs
Publication statusPublished - 3 Jun 2014

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