An Extended PD-L2 Cytoplasmic Domain Results From Alternative Splicing in NSCLC Cells. / Dietz, Lisa Loksø; Furman, Natasja Toft; Larsen, Trine Vilsbøll et al.
In: Journal of Immunotherapy, Vol. 45, No. 9, 11.2022, p. 379-388.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Animal Models of Choroidal Neovascularization : A Systematic Review. / Fabian-Jessing, Bjørn K; Jakobsen, Thomas Stax; Jensen, Emilie Grarup et al.
In: Investigative Ophthalmology & Visual Science, Vol. 63, No. 9, 11, 08.2022.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
VEGFA-targeting miR-agshRNAs combine efficacy with specificity and safety for retinal gene therapy. / Alsing, Sidsel; Doktor, Thomas Koed; Askou, Anne Louise et al.
In: Molecular Therapy - Nucleic Acids, Vol. 28, 06.2022, p. 58-76.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Simple Autofluorescence-Restrictive Sorting of eGFP+ RPE Cells Allows Reliable Assessment of Targeted Retinal Gene Therapy. / Kalaee, Sidsel Alsing; Lindholm, Anna Bøgh; Haldrup, Jakob et al.
In: Frontiers in Drug Delivery, Vol. 2, 898568, 05.2022.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Single AAV-mediated CRISPR-Nme2Cas9 efficiently reduces mutant hTTR expression in a transgenic mouse model of transthyretin amyloidosis. / Wen, Jinkun; Cao, Tianqi; Wu, Jinni et al.
In: Molecular Therapy, Vol. 30, No. 1, 01.2022, p. 164-174.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Variants in the Ethylmalonyl-CoA Decarboxylase (ECHDC1) Gene; a Novel Player in Ethylmalonic Aciduria? / Fogh, Sarah; Dipace, Graziana; Bie, Anne et al.
In: Journal of Inherited Metabolic Disease, Vol. 44, No. 5, 09.2021, p. 1215-1225.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Methylation silencing and reactivation of exogenous genes in lentivirus-mediated transgenic mice. / Wen, Jinkun; Wu, Jinni; Cao, Tianqi et al.
In: Transgenic Research, Vol. 30, No. 1, 02.2021, p. 63-76.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
MicroRNA-106b Regulates Expression of the Tumour Suppressors p21 and TXNIP and Promotes Tumour Cell Proliferation in Mycosis Fungoides. / Lindahl, Lise M; Gluud, Maria; Emmanuel, Thomas et al.
In: Acta Dermato-Venereologica, Vol. 100, adv00270, 09.2020.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Generation of Inducible CRISPRi and CRISPRa Human Stromal/Stem Cell Lines for Controlled Target Gene Transcription during Lineage Differentiation. / Chen, Li; Shi, Kaikai; Qiu, Weimin et al.
In: Stem Cells International, Vol. 2020, 8857344, 2020.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene Therapy. / Askou, Anne Louise; Alsing, Sidsel; Benckendorff, Josephine N.E. et al.
In: Molecular Therapy - Nucleic Acids, Vol. 16, 07.06.2019, p. 38-50.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Efficient Knockdown and Lack of Passenger Strand Activity by Dicer-Independent shRNAs Expressed from Pol II-Driven MicroRNA Scaffolds. / Kaadt, Erik; Alsing, Sidsel; Cecchi, Claudia R. et al.
In: Molecular Therapy - Nucleic Acids, Vol. 14, 01.03.2019, p. 318-328.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs. / Hollensen, Anne Kruse; Andersen, Sofie; Hjorth, Karina et al.
In: Molecular Therapy - Nucleic Acids, Vol. 13, 07.12.2018, p. 365-375.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein. / Dalsgaard, Trine; Kaadt, Claudia Regina Cecchi; Askou, Anne Louise et al.
In: Molecular Therapy - Nucleic Acids, Vol. 12, 07.09.2018, p. 672-683.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
The role of miR-29a in HIV-1 replication and latency. / Frattari, Giacomo; Aagaard, Lars; Denton, Paul W.
In: Journal of virus eradication, Vol. 3, No. 4, 01.10.2017, p. 185-191.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Improved microRNA suppression by WPRE-linked Tough Decoy microRNA sponges. / Hollensen, Anne Kruse; Thomsen, Rune; Bak, Rasmus O et al.
In: RNA, Vol. 23, No. 8, 08.2017, p. 1247-1258.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Suppression of Choroidal Neovascularization in Mice by Subretinal Delivery of Multigenic Lentiviral Vectors Encoding Anti-Angiogenic MicroRNAs. / Askou, Anne Louise; Benckendorff, Josephine Natalia Esther; Holmgaard, Andreas et al.
In: Human Gene Therapy. Methods, Vol. 28, No. 4, 08.2017, p. 222-233.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Induced pluripotent stem cells derived from a patient with autosomal dominant familial neurohypophyseal diabetes insipidus caused by a variant in the AVP gene. / Toustrup, Lise Bols; Zhou, Yan; Kvistgaard, Helene et al.
In: Stem Cell Research, Vol. 19, 03.2017, p. 37-42.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Mitochondrial Spare Respiratory Capacity Is Negatively Correlated With Nuclear Reprogramming Efficiency. / Zhou, Yan; Al-Saaidi, Rasha Abdelkadhem; Guerra, Paula Fernandez et al.
In: Stem Cells and Development, Vol. 26, No. 3, 02.2017, p. 166-176.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Investigation of the disease mechanisms of Short-Chain Acyl-CoA Dehydrogenase deficiency by biallelic knockout using CRISPR/Cas9. / Fogh, Sarah; Olsen, Rikke Katrine Jentoft; Gregersen, Niels et al.
2016. Poster session presented at CRISPR genome editing: From high-throughput screening to disease models, Copenhagen, Denmark.Research output: Contribution to conference › Poster › Research
Improved RNAi target knockdown using safe miR-451 based hairpins. / Kaadt, Erik; Aagaard, Lars.
2016.Research output: Contribution to conference › Poster › Research › peer-review
589. Short Hairpin RNAs Based on miR-451 Show Potent Knockdown without Passenger Strand Activity. / Kaadt, Erik; Aagaard, Lars.
2016. S233-S234.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Partial correction of the dwarf phenotype by non-viral transfer of the growth hormone gene in mice : Treatment age is critical. / Higuti, Eliza; Cecchi, Cláudia R; Oliveira, Nélio A J et al.
In: Growth Hormone & I G F Research, Vol. 26, 02.2016, p. 1-7.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system. / Zhou, Yan; Liu, Yong; Hussmann, Dianna et al.
In: Cellular and Molecular Life Sciences, Vol. 73, No. 13, 11.01.2016, p. 2543-63.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Efficient in vivo gene transfer to xenotransplanted human skin by lentivirus-mediated, but not by AAV-directed, gene delivery. / Jakobsen, Maria Vad; Askou, Anne Louise; Dokkedahl, Karin Stenderup et al.
2015. Poster session presented at Annual Congress The European Society of Gene and Cell Therapy (ESGCT), Helsinki, Finland.Research output: Contribution to conference › Poster › Research › peer-review
Robust Lentiviral Gene Delivery But Limited Transduction Capacity of Commonly Used Adeno-Associated Viral Serotypes in Xenotransplanted Human Skin. / Jakobsen, Maria; Askou, Anne Louise; Stenderup, Karin et al.
In: Human Gene Therapy. Methods, Vol. 26, No. 4, 08.2015, p. 123-33.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Molecular mechanisms in DM1 - a focus on foci. / Pettersson, Olof Joakim; Aagaard, Lars; Jensen, Thomas G. et al.
In: Nucleic Acids Research, Vol. 43, No. 4, 27.02.2015, p. 2433-2441.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity. / Kang, Ran; Zhou, Yan; Tan, Shuang et al.
In: Stem Cell Research & Therapy, Vol. 6, No. 1, 2015, p. 144.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors. / Askou, Anne Louise; Aagaard, Lars; Kostic, Corinne et al.
In: Molecular therapy. Methods & clinical development, Vol. 2, 2015, p. 14064.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1. / Pettersson, Olof Joakim; Aagaard, Lars; Andrejeva, Diana et al.
In: Nucleic Acids Research, Vol. 42, No. 11, 03.05.2014, p. 7186-7200.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
A novel homologous model for gene therapy of dwarfism by non-viral transfer of the mouse growth hormone gene into immunocompetent dwarf mice. / Cecchi, Claudia R; Higuti, Eliza; Oliveira, Nelio A J et al.
In: Current Gene Therapy, Vol. 14, No. 1, 02.2014, p. 44-51.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
An homologous model of gene therapy by in vivoadministration of a plasmid containing the mouse growth hormone gene in immunocompetentdwarf mice. / Cecchi, Cláudia R; Dagnæs-Hansen, Frederik; Aagaard, Lars et al.
2014. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Versailles, France.Research output: Contribution to conference › Poster › Research › peer-review
Breeding a PKU-mouse model on Phe-free diet, is it possible? Je li moguce uzgojiti model misa s fenilketornurijom na dijeti bez fenilalanine? / Dagnæs-Hansen, Frederik; Johansen, Karen Singers; Vorup-Jensen, Thomas et al.
2014.Research output: Contribution to conference › Conference abstract for conference › Research
Integration-deficient lentiviral vectors as gene delivery vehicles for treatment of AMD. / Askou, Anne Louise; Hebsgaard Holm-Nielsen, Maria; Jensen, Thomas G. et al.
2014. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Versailles, France.Research output: Contribution to conference › Poster › Research › peer-review
Multigenic lentiviral vectors for anti-angiogenic treatment of age-related macular degeneration (AMD). / Askou, Anne Louise; Aagaard, Lars; Kostic, Corinne et al.
2013. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Madrid, Spain.Research output: Contribution to conference › Poster › Research
Viral vs. non-viral gene therapy to improve tendon healing: Electrotransfer leads to rapid gene expression compared to AAV-based delivery. / Svensson, Sys Hasslund; Gissel, Hanne; Danielsen, Carl Christian et al.
2013. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Madrid, Spain.Research output: Contribution to conference › Poster › Research › peer-review
AAV-delivered polycistronic microRNA-clusters for knockdown of VEGF in vivo. / Pihlmann, Maria; Askou, Anne Louise; Aagaard, Lars et al.
In: The Journal of Gene Medicine, 2012.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
An homologous model of gene therapy by in vivo administration of a plasmid containing the mouse growth hormone gene in immunocompetent dwarf mice. / Cecchi, Claudia R.; Dagnæs-Hansen, Niels Frederik; Aagaard, Lars et al.
2012. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Versailles, France.Research output: Contribution to conference › Poster › Research › peer-review
Silencing of endogenous envelope genes in human choriocarcinoma cells shows that envPb1 is involved in heterotypic cell fusions. / Aagaard, Lars; Bjerregaard, Bolette; Kjeldbjerg, Anders L et al.
In: Journal of General Virology, Vol. 93, No. 8, 2012, p. 1696-1699.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
microRNA-clusters for AAV-based treatment of age-related macular degeneration (AMD). / Pihlmann, Maria; Aagaard, Lars; Hindkjær, Tina et al.
In: European Society of Gene & Cell Therapy, abstract book, 22.10.2010, p. 411-411.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research › peer-review
Rational design of micro-RNA-like bifunctional siRNAs targeting HIV and the HIV coreceptor CCR5. / Ehsani, Ali; Saetrom, Pål; Zhang, Jane et al.
In: Molecular Therapy, Vol. 18, No. 4, 2010, p. 796-802.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Regulation of cytokine expression by lentivirus-encoded RNA antagomirs. / Bak, Rasmus Otkjær; Barrett Petersen, Line; Moldt, Brian et al.
2010. Poster session presented at American Society of Gene Therapy 13th Annual Meeting, Washington, United States.Research output: Contribution to conference › Poster › Research
B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity. / Brudek, Tomasz; Christensen, Tove; Aagaard, Lars et al.
In: Retrovirology, Vol. 6, 2009, p. 104.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs. / Aagaard, L; Zhang, J; von Eije, K J et al.
In: Gene Therapy Weekly, Vol. 15, No. 23, 2008, p. 1536-49.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution. / Kjeldbjerg, Anders; Villesen, Palle; Aagaard, Lars et al.
In: B M C Evolutionary Biology, Vol. 8, No. 1, 2008, p. 266.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
A Facile Lentiviral Vector System for Expression of Doxycycline-Inducible shRNAs: Knockdown of the Pre-miRNA Processing Enzyme Drosha. / Aagaard, Lars; Amarzguioui, Mohammed; Sun, Guihua et al.
In: Molecular Therapy, Vol. 15, No. 5, 2007, p. 938-945.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
A facile lentiviral vector system for expression of doxycycline-inducible shRNAs: knockdown of the pre-miRNA processing enzyme Drosha. / Aagaard, Lars; Amarzguioui, Mohammed; Sun, Guihua et al.
In: Molecular Therapy, Vol. 15, No. 5, 2007, p. 938-45.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
An active 70 million year old viral infection in humans. / Kjeldbjerg, Anders Langfelt; Villesen, Palle; Aagaard, Lars et al.
2007. Poster session presented at High Throughput Biology: Genomics, Fluxomics, Proteomics, and Interactomics, Denmark.Research output: Contribution to conference › Poster › Research
Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC. / Castanotto, Daniela; Sakurai, Kumi; Lingeman, Robert et al.
In: Nucleic Acids Research, Vol. 35, No. 15, 2007, p. 5154-64.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Distance Constraints between microRNA Target Sites Dictate Efficacy and Cooperativity. / Sætrom, Pål; Heale, Bret S. E.; Snøve, Ola et al.
In: Nucleic Acids Research (NAR), 2007.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Distance constraints between microRNA target sites dictate efficacy and cooperativity. / Saetrom, Pål; Heale, Bret S E; Snøve, Ola et al.
In: Nucleic Acids Research, Vol. 35, No. 7, 2007, p. 2333-42.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
RNAi therapeutics: principles, prospects and challenges. / Aagaard, Lars; Rossi, John J.
In: Advanced Drug Delivery Reviews, Vol. 59, No. 2-3, 2007, p. 75-86.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research
The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. / Weinberg, Marc S.; Villeneuve, Louisa M.; Ehsani, Ali et al.
In: RNA, Vol. 12, No. 2, 2006, p. 256–262.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. / Weinberg, Marc S; Villeneuve, Louisa M; Ehsani, Ali et al.
In: RNA, Vol. 12, No. 2, 2006, p. 256-62.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
The ~30-million-year-old ERVPb1 envelope gene is evolutionarily conserved among hominoids and Old World monkeys. / Aagaard, Lars; Villesen, Palle; Kjeldbjerg, Anders Langfelt et al.
In: Genomics, Vol. 86, No. 6, 01.12.2005, p. 685-691.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Din indre virus. / Aagaard, Lars; Villesen, Palle.
In: Jyllands-Posten, 2005.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
The ~30-million-year-old ERVPb1 envelope gene is evolutionarily conserved among hominoids and Old World monkeys. / Aagaard, Lars; Villesen, Palle; Kjeldbjerg, Anders Langfelt et al.
In: Genomics, Vol. 86, No. 6, 2005.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Efficient replication of full-length murine leukemia viruses modified at the dimer initiation site regions. / Aagaard, Lars; Rasmussen, Søren Vestergaard; Mikkelsen, Jacob Giehm et al.
In: Virology, Vol. 318, No. 1, 05.01.2004, p. 360-370.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Identification of endogenous retroviral reading frames in the human genome. / Villesen, Palle; Aagaard, Lars; Wiuf, Carsten et al.
In: Retrovirology, Vol. 1, No. 32, 01.01.2004, p. 1-13.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
An RNA secondary structure bias for non-homologous reverse transcriptase-mediated deletions in vivo. / Duch, Mogens; Carrasco, Maria L; Jespersen, Thomas et al.
In: Nucleic Acids Research, Vol. 32, No. 6, 2004, p. 2039-2048.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Din indre virus. / Aagaard, L.; Villesen, Palle.
In: Aktuel Naturvidenskab, Vol. 6, 2004, p. 10-13.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Communication
Din indre virus : den gode, den onde og den helt ukendte. / Aagaard, Lars; Villesen, Palle.
In: Aktuel Naturvidenskab, No. 6, 2004.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Fv1-like restriction of N-tropic replication-competent murine leukaemia viruses in mCAT-1-expressing human cells. / Aagaard, Lars; Mikkelsen, Jacob Giehm; Warming, Søren et al.
In: Journal of General Virology, Vol. 83, No. Pt 2, 2002, p. 439-42.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
New retroviral vector system comprising a retroviral vector having modified heterologous or synthetic dimerization sequence and a transcript of different retrovirus useful for preparing a composition or medicament for gene therapy. / Pedersen, Finn Skou (Inventor); Mikkelsen, Jacob Giehm (Inventor); Rasmussen, Søren Vestergaard (Inventor) et al.
Patent No.: WO200292825-A2.Research output: Patent