Kathrin Weyer

2024

Amiloride Reduces Urokinase/Plasminogen-Driven Intratubular Complement Activation in Glomerular Proteinuria

Lissel Isaksson, G., Hinrichs, G. R., Andersen, H., Bach, M. L., Weyer, K., Zachar, R., Henriksen, J. E., Madsen, K., Lund, I. K., Mollet, G., Bistrup, C., Birn, H., Jensen, B. L. & Palarasah, Y., Apr 2024, In: Journal of the American Society of Nephrology. 35, 4, p. 410-425 16 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Filtration and tubular handling of EWE-hC3Nb1, a complement inhibitor nanobody, in wild type mice and a mouse model of proteinuric kidney disease

Fast, M. S., Weyer, K., Pedersen, H., Andersen, G. R. & Birn, H., Feb 2024, In: FEBS Open Bio. 14, 2, p. 322-330 9 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2023

Megalin-Mediated Endocytosis in the Kidney Proximal Tubule: Relevance to Regulation of the Renal Renin-Angiotensin System

Hummelgaard, S. & Weyer, K., 2023, In: Nephron. 147, 3-4, p. 244–249 6 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Proprotein convertase subtilisin/kexin type 9 targets megalin in the kidney proximal tubule and aggravates proteinuria in nephrotic syndrome

Skeby, C. K., Hummelgaard, S., Gustafsen, C., Petrillo, F., Frederiksen, K. P., Olsen, D., Kristensen, T., Ivarsen, P., Madsen, P., Christensen, E. I., Nielsen, R., Birn, H., Glerup, S. & Weyer, K., Oct 2023, In: Kidney International. 104, 4, p. 754-768 15 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

9 Downloads (Pure)

Targeting PCSK9 to tackle cardiovascular disease

Hummelgaard, S., Vilstrup, J. P., Gustafsen, C., Glerup, S. & Weyer, K., Sept 2023, In: Pharmacology & Therapeutics. 249, 16 p., 108480.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Open Access

File

14 Downloads (Pure)

Tubular albumin uptake: is there evidence for a quantitatively important, receptor-independent mechanism?

Birn, H., Nielsen, R. & Weyer, K., Dec 2023, In: Kidney International. 104, 6, p. 1069-1073 5 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review

2022

The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus

Voss, L. F., Howarth, A. J., Wittenborn, T. R., Hummelgaard, S., Juul-Madsen, K., Kastberg, K. S., Pedersen, M. K., Jensen, L., Papanastasiou, A. D., Vorup-Jensen, T., Weyer, K. & Degn, S. E., Dec 2022, In: Frontiers in Immunology. 13, 1021370.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2020

Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin

Ren, Q., Weyer, K., Rbaibi, Y., Long, K. R., Tan, R. J., Nielsen, R., Ilsö Christenssen, E., Baty, C. J., Kashlan, O. B. & Weisz, O. A., May 2020, In: American journal of physiology. Renal physiology. 318, 5, p. F1284-F1294 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Sodium retention by uPA-plasmin-ENaC in nephrotic syndrome: Authors reply

Hinrichs, G. R., Weyer, K., Friis, U. G., Svenningsen, P., Lund, I. K., Nielsen, R., Mollet, G., Antignac, C., Bistrup, C., Jensen, B. L. & Birn, H., 2020, In: Acta Physiologica (Print). 228, 4, e13432.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Letter › peer-review

2019

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

Tachibana, M., Holm, M.-L., Liu, C.-C., Shinohara, M., Aikawa, T., Oue, H., Yamazaki, Y., Martens, Y. A., Murray, M. E., Sullivan, P. M., Weyer, K., Glerup, S., Dickson, D. W., Bu, G. & Kanekiyo, T., Mar 2019, In: Journal of Clinical Investigation. 129, 3, p. 1272-1277 6 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Urokinase-type plasminogen activator contributes to amiloride-sensitive sodium retention in nephrotic range glomerular proteinuria in mice

Hinrichs, G. R., Weyer, K., Friis, U. G., Svenningsen, P., Lund, I. K., Nielsen, R., Mollet, G., Antignac, C., Bistrup, C., Jensen, B. L. & Birn, H., 2019, In: Acta Physiologica (Online). 227, 4, 14 p., e13362.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2018

Abolishment of proximal tubule albumin endocytosis does not affect plasma albumin during nephrotic syndrome in mice

Weyer, K., Andersen, P. K., Schmidt, K., Mollet, G., Antignac, C., Birn, H., Nielsen, R. & Christensen, E. I., 1 Feb 2018, In: Kidney International. 93, 2, p. 335-342 8 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

The Authors Reply

Weyer, K., Birn, H., Nielsen, R. & Christensen, E. I., Apr 2018, In: Kidney International. 93, 4, p. 1014-1015 2 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research

2017

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor

Gustafsen, C., Olsen, D., Vilstrup, J., Lund, S., Reinhardt, A., Wellner, N., Larsen, T., Andersen, C. B. F., Weyer, K., Li, J.-P., Seeberger, P. H., Thirup, S., Madsen, P. & Glerup, S., 11 Sept 2017, In: Nature Communications. 8, 1, p. 503 503.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Megalin dependent urinary cystatin C excretion in ischemic kidney injury in rats

Jensen, D., Kierulf-Lassen, C., Kristensen, M. L. V., Nørregaard, R., Weyer, K., Nielsen, R., Christensen, E. I. & Birn, H., 2017, In: PLOS ONE. 12, 6, 13 p., e0178796.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2014

Megalin-Mediated Specific Uptake of Chitosan/siRNA Nanoparticles in Mouse Kidney Proximal Tubule Epithelial Cells Enables AQP1 Gene Silencing

Gao, S., Hein, S., Dagnæs-Hansen, F., Weyer, K., Yang, C., Nielsen, R., Christensen, E. I., Fenton, R. A. & Kjems, J., 2014, In: Theranostics. 4, 10, p. 1039-51 13 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Pregnancy-associated plasma protein-A2 modulates development of cranial cartilage and angiogenesis in zebrafish embryos

Kjaer-Sorensen, K., Engholm, D. H., Jepsen, M. R., Morch, M. G., Weyer, K., Hefting, L. L., Skov, L. L., Laursen, L. S. & Oxvig, C., 18 Sept 2014, In: Journal of Cell Science.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2013

Increased lysosomal proteolysis counteracts protein accumulation in the proximal tubule during focal segmental glomerulosclerosis

Nielsen, R., Mollet, G., Esquivel, E. L., Weyer, K., Nielsen, P. K., Antignac, C. & Christensen, E. I., 12 Nov 2013, In: Kidney International. 84, p. 902-910

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Renal Uptake of 99mTc-Dimercaptosuccinic Acid Is Dependent on Normal Proximal Tubule Receptor-Mediated Endocytosis

Weyer, K., Nielsen, R., Petersen, S. V., Christensen, E. I., Rehling, M. & Birn, H., Jan 2013, In: Journal of Nuclear Medicine. 54, 1, p. 159-165

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

The authors reply:

Nielsen, R., Weyer, K., Birn, H. & Christensen, E. I., Nov 2013, In: Kidney International. 84, 5, p. 1050-1 2 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2012

Endocytic receptors in the renal proximal tubule

Christensen, E. I., Birn, H., Storm, T., Weyer, K. & Nielsen, R., 2012, In: Physiology. 27, 4, p. 223-36 14 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Generation of urinary albumin fragments does not require proximal tubular uptake.

Weyer, K., Nielsen, R., Christensen, E. I. & Birn, H., 2012, In: Journal of the American Society of Nephrology. 23, 4, p. 591-96

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2011

Mouse model of proximal tubule endocytic dysfunction

Weyer, K., Storm, T., Shan, J., Vainio, S., Kozyraki, R., Verroust, P. J., Christensen, E. I. & Nielsen, R., 16 Sept 2011, In: Nephrology Dialysis Transplantation. 26, p. 3446-3451

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Placental regulation of peptide hormone and growth factor activity by proMBP

Weyer, K. & Glerup, S., 1 Jun 2011, In: Biology of Reproduction. 84, 6, p. 1077-86 10 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2009

Lin12-Notch repeat (LNR) modules in regulation of proteolysis

Weyer, K., 2009

Research output: Book/anthology/dissertation/report › Ph.D. thesis

2007

A substrate specificity-determining unit of three Lin12-Notch repeat modules is formed in trans within the pappalysin-1 dimer and requires a sequence stretch C-terminal to the third module

Weyer, K., Boldt, H. B., Poulsen, C. B., Kjaer-Sorensen, K., Gyrup, C. & Oxvig, C., 2007, In: Journal of Biological Chemistry. 282, 15, p. 10988-99 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2004

Cell surface adhesion of pregnancy-associated plasma protein-A is mediated by four clusters of basic residues located in its third and fourth CCP module

Weyer, K., Overgaard, M. T., Laursen, L. S., Nielsen, C. G., Schmitz, A., Christiansen, M., Sottrup-Jensen, L., Giudice, L. C. & Oxvig, C., 2004, In: FEBS journal. 271, p. 1525-1535 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

The Lin12-Notch Repeats of Pregnancy-associated Plasma Protein-A Bind Calcium and Determine Its Proteolytic Specificity

Boldt, H. B., Kjaer-Sorensen, K., Overgaard, M. T., Weyer, K., Poulsen, C. B., Sottrup-Jensen, L., Conover, C. A., Giudice, L. C. & Oxvig, C., 10 Sept 2004, In: Journal of Biological Chemistry. 279, 37, p. 38525-38531 7 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2002

Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeats

Laursen, L. S., Overgaard, M. T., Weyer, K., Boldt, H. B., Ebbesen, P., Christiansen, M., Sottrup-Jensen, L., Giudice, L. C. & Oxvig, C., 6 Dec 2002, In: Journal of Biological Chemistry. 277, 49, p. 47225-34 10 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2001

Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin

Boldt, H. B., Overgaard, M. T., Laursen, L. S., Weyer, K., Sottrup-Jensen, L., Oxvig, C. & Weyer, K., 1 Sept 2001, In: Biochemical Journal. 358, Pt 2, p. 359-367 9 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Kathrin Weyer

Research output

Search results