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Kristjar Skajaa

Effects of indomethacin on postoperative pain and nausea after transcervical endometrial resection

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The purpose of this study was to evaluate the effects of indomethacin on patients with postoperative need for opiate analgesics and antiemetics, the experience of pain, nausea and headache and the postoperative serum levels of sodium (S-Na) after transcervical resection of the endometrium (TCRE). A randomized, double-blind placebo-controlled study of the effects of 50 mg indomethacin administered intravenously after induction of anaesthesia prior to TCRE was set up and 60 patients with meno-metrorrhagia were subjected to TCRE. A number of patients required standard doses of ketobemidon as an opiate analgesic and dixyrazin as an antiemetic. Ketobemidon was needed for treatment of pain in 57% of the patients in the placebo group and 31% in the indomethacin group, respectively, corresponding to a reduction of 47%. The need for dixyrazin and the incidence and intensity of nausea was the same. The intensity of headache was generally low. Indomethacin treatment did not interfere with the spontaneous normalization of hyponatraemia in patients having absorbed 500 ml glycine or more during the operation. Indomethacin administered at induction of anaesthesia reduced the number of patients requiring opiate analgesic treatment after TCRE, while the need to treat nausea remained unaffected. Indomethacin did not seem to interfere with the spontaneous normalization of hyponatriaemia secondary to absorption of the irrigating solution.

Original languageEnglish
JournalGynaecological Endoscopy
Pages (from-to)225-228
Number of pages4
Publication statusPublished - 28 Dec 1994
Externally publishedYes

    Research areas

  • Endometrium, Nausea, Pain, Resection

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